Polymeric treatment compositions

Patent metadata

Field	Value
Publication number	US-2016243273-A1
Application number	US-201514736145-A
Country	US
Kind code	A1
Filing date	Jun 10, 2015
Priority date	Oct 15, 2012
Publication date	Aug 25, 2016
Grant date	—

Abstract

Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

First claim

1 . A polymer including:
a biodegradable linkage to a visualization agent having at least one aromatic ring, wherein the polymer is substantially stable and wherein the polymer is soluble in a non-physiological solution and insoluble in a physiological solution.

2 . The polymer of claim 1 , wherein the biodegradable linkage is Seq. ID 1, Seq. ID 2, Seq. ID 3, Seq. ID 4, Seq. ID 5, Seq. ID 6, Seq. ID 7, Seq. ID 8, Seq. ID 9, Seq. ID 10, Seq. ID 11, Seq. ID 12, or Seq. ID 13.

3 . The polymer of claim 1 , wherein the biodegradable linkage is an ester or a polyester.

4 . The polymer of claim 1 , wherein a monomer included in the polymer is 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2-yloxy)ethoxy)ethyl acrylate.

5 . The polymer of claim 1 including a monomer including at least one hydroxyl group.

6 . The polymer of claim 5 , wherein the monomer is an acrylate.

7 . The polymer of claim 6 , wherein the acrylate is hydroxyethyl methacrylate.

8 . The polymer of claim 1 , wherein the non-physiological solution is dimethyl formamide.

9 . The polymer of claim 1 , wherein the non-physiological solution is dimethyl sulfoxide.

10 . The polymer of claim 1 including a reaction product of between about 75% and about 98% 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2-yloxy)ethoxy)ethyl acrylate, between about 2% and about 25% hydroxyethyl methacrylate, and less than 1% azobisisobutyronitrile.

11 . The polymer of claim 1 including a reaction product of between about 85% and about 98% 1-((2-(methacryloyloxy)ethoxy)carbonyloxy) ethyl 3,5-diacetamido-2,4,6-triiodobenzoate, between about 2% and about 15% hydroxyethyl methacrylate, and less than 1% azobisisobutyronitrile.

12 . A polymeric solution comprising:
a solvent including a solubilized polymer, wherein the solubilized polymer includes a biodegradable linkage to a visualization agent having at least one aromatic ring and at least one hydroxyl group.

13 . The polymeric solution of claim 12 , wherein the biodegradable linkage is Seq. ID 1, Seq. ID 2, Seq. ID 3, Seq. ID 4, Seq. ID 5, Seq. ID 6, Seq. ID 7, Seq. ID 8, Seq. ID 9, Seq. ID 10, Seq. ID 11, Seq. ID 12, Seq. ID 13, an ester, or a polyester.

14 . The polymeric solution of claim 12 , wherein a monomer included in the polymer is 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2-yloxy)ethoxy)ethyl acrylate.

15 . The polymeric solution of claim 12 , wherein a monomer included in the polymer is hydroxyethyl methacrylate.

16 . The polymeric solution of claim 12 , wherein the concentration of the solubilized polymer in the solvent is about 1% w/w to about 50% w/w.

17 . The polymeric solution of claim 12 , wherein the solvent is dimethyl formamide.

18 . The polymeric solution of claim 17 , wherein the solvent is dimethyl formamide.

19 . The polymeric solution of claim 12 , wherein the solubilized polymer is a reaction product of between about 75% and about 98% 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2-yloxy)ethoxy)ethyl acrylate, between about 2% and about 25% hydroxyethyl methacrylate, and less than 1% azobisisobutyronitrile.

20 . The polymeric solution of claim 12 , wherein the solubilized polymer is a reaction product of between about 85% and about 98% 1-((2-(methacryloyloxy)ethoxy)carbonyloxy) ethyl 3,5-diacetamido-2,4,6-triiodobenzoate, between about 2% and about 15% hydroxyethyl methacrylate, and less than 1% azobisisobutyronitrile.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Constant Michael J
• Keeley Edward Michael
• Greene Rob
• Harris Clayton

Classifications

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P7/04

  Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title

• A61L24/06 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} · CPC title

• A61L24/001

  Use of materials characterised by their function or physical properties · CPC title