Inverting thrombectomy apparatuses having enhanced tracking

Patent metadata

Field	Value
Publication number	US-2019133626-A1
Application number	US-201816183162-A
Country	US
Kind code	A1
Filing date	Nov 7, 2018
Priority date	Nov 9, 2017
Publication date	May 9, 2019
Grant date	—

Abstract

Mechanical thrombectomy apparatuses, and particularly knitted rolling tube mechanical thrombectomy apparatuses configured to have improved tracking for delivery through tortious vessels are described herein. Also described herein are methods of removing clots using a mechanical thrombectomy apparatuses in which the clot is larger than the tractor portion of the mechanical thrombectomy apparatus.

First claim

What is claimed is:

1 . An inverting tube apparatus for removing a clot from a vessel, the apparatus comprising:
an intermediate catheter; an inversion support catheter within a lumen of the intermediate catheter; a puller within a lumen of the inversion support catheter; and a knitted tube extending over the inversion support catheter, the knitted tube having a first end coupled at a distal end region of the puller and a second end that is free, wherein the knitted tube is configured to be pulled proximally into the inversion support catheter by pulling the puller proximally so that the knitted tube rolls and inverts over a distal end of the inversion support catheter, wherein the knitted tube comprises a filament knitted to form a plurality of interlocking loop stitches, and wherein each loop stitch has a stitch length that is between 0.5 mm and 10 mm.

2 . The apparatus of claim 1 , wherein the knitted tube extends over the inversion support catheter with an inner diameter that is within 20% of the outer diameter of the inversion support catheter.

3 . The apparatus of claim 2 , wherein the second end of the knitted tube comprises a cuff that is less flexible that a region of the knitted tube adjacent to the cuff.

4 . An inverting tube apparatus for removing a clot from a vessel, the apparatus comprising:
an inversion support catheter; a puller within a lumen of the inversion support catheter; and a knitted tube extending over the inversion support catheter in a first configuration, the knitted tube having a first end coupled to a distal end region of the puller, and a second end that is free to move relative to the inserting support catheter, wherein the knitted tube is configure to be pulled proximally into the inversion support catheter by pulling the puller proximally so that the knitted tube rolls and inverts over a distal end of the inversion support catheter into a second configuration within the inversion support catheter; further wherein the knitted tube in the first configuration has an expanded outer diameter that is between 0.5 mm and 12 mm for a first region of the knitted tube that is adjacent to the first end, and the knitted tube in the second configuration has an inner diameter that is greater than 30% of an inner diameter of the inversion support catheter, and wherein a second region of the knitted tube adjacent to the second end has an expanded outer diameter that is less than the expanded outer diameter of the region of the knitted tube adjacent to the first end and within 20% of an outer diameter of the inversion support catheter.

5 . The apparatus of claim 4 , further comprising a cuff at the second end, wherein the cuff has a stiffness that is greater than a region of the knitted tube adjacent to the cuff.

6 . The apparatus of claim 4 , further comprising a stop configured to limit the travel of the knitted tube so that the second end does not roll and invert over the distal end of the inversion support catheter.

7 . The apparatus of claim 4 , wherein the knitted tube is shape set so that the first configuration has the outer diameter between 0.5 mm and 10 mm for the region of the kitted tube adjacent to the first end, and the knitted tube in the second configuration has an inner diameter that is greater than 60% of the inner diameter of the inversion support catheter.

8 . The apparatus of claim 4 , wherein the first region of the kitted tube is at least 2 cm long, wherein the second region of the knitted tube is at least 1 cm long.

9 . The apparatus of claim 4 , wherein the knitted tube comprises a filament knitted to form a plurality of interlocking loop stitches, wherein each loop stitch has a stitch length that is between 0.5 mm and 10 mm, wherein, at a region of the knitted tube that is inverting from the first configuration to the second configuration, a sub-set of the plurality of loop stitches forming the knitted tube extend proud from the long axis of the knitted tube by between 0.5 mm and 10 mm.

10 . The apparatus of claim 4 , further comprising an intermediate catheter having a lumen, wherein the inversion support catheter is within the lumen of the intermediate support catheter and may be extended distally from the intermediate catheter to deploy the knitted tube so that the knitted tube may expand into the first configuration.

11 . A pre-loaded inverting mechanical thrombectomy apparatus for removing a clot from a vessel configured to be delivered through a tortious anatomy, the apparatus comprising:
an intermediate catheter having a distal end; an inversion support catheter within a lumen of the intermediate catheter, the inversion support catheter having a distal end and a distal end opening; a puller extending within the inversion support catheter; and a flexible tube extending proximally from a distal end region of the puller so that a distal-facing face of the puller extends distally beyond the flexible tube, wherein the puller extends from the distal end of the intermediate catheter and the distal end opening of the inversion support catheter; wherein the distal end opening of the inversion support is held within the lumen of the intermediate catheter, and wherein the flexible tube extends between the inversion support catheter and the intermediate catheter.

12 . The apparatus of claim 11 , wherein the inversion support catheter comprises a plurality of slots or cut-out regions along its length to enhance flexibility while maintaining column strength such that the inversion support catheter is able to withstand at least about 500 g of compressive force.

13 . The apparatus of claim 11 , wherein the inversion support catheter comprises a plurality of slits or openings around the perimeter of the inversion support catheter and down the length of the inversion support catheter.

14 . The apparatus of claim 11 , wherein the inversion support catheter is removably secured to the intermediate catheter so that the intermediate support catheter and the intermediate catheter move relative to each other.

15 . The apparatus of claim 11 , wherein puller comprises a micro catheter or a guidewire.

16 . A pre-loaded inverting mechanical thrombectomy apparatus for removing a clot from a vessel configured to be delivered through a tortious anatomy, the apparatus comprising:
an intermediate catheter having a distal end; an inversion support catheter extending distally from a lumen of the intermediate catheter, the inversion support catheter having a distal end and a distal end opening; a puller extending distally within the inversion support catheter; and a flexible tube extending proximally from a distal end region of the puller and between the intermediate catheter and the inversion support catheter, wherein the puller extends from the distal end of the intermediate catheter and the distal end opening of the inversion support catheter; and wherein the distal end opening of the inversion support is held within the lumen of the intermediate catheter, and wherein the flexible tube extends between the inversion support catheter and the intermediate catheter, and wherein the puller and inversion support catheter are releasably held together so that they move together while advancing distally within a vessel lumen.

17 . The apparatus of claim 16 , wherein the inversion support catheter comprises a plurality of slots or cut-out regions along its length to enhance flexibility while maintaining column strength such that the inversion support catheter is able to withstand at least about 500 g of compressive f

Assignees

• Stryker Corp

Inventors

• Wallace Michael P
• Garabedian Robert
• Leguidleguid Roy
• Greenhalgh E Skott

Classifications

• A61B2017/22079

  with suction of debris · CPC title

• A61M25/0119

  Eversible catheters · CPC title

• A61B2017/00867

  shape memory effect · CPC title

• A61B17/22031 Primary

  Gripping instruments, e.g. forceps, for removing or smashing calculi (A61B17/221 takes precedence) · CPC title

• A61B17/320725

  with radially expandable cutting or abrading elements (A61B17/32075 takes precedence) · CPC title