Inverting thrombectomy apparatuses having enhanced tracking

Patent metadata

Field	Value
Publication number	US-2019133627-A1
Application number	US-201816183171-A
Country	US
Kind code	A1
Filing date	Nov 7, 2018
Priority date	Nov 9, 2017
Publication date	May 9, 2019
Grant date	—

Abstract

Mechanical thrombectomy apparatuses, and particularly knitted rolling tube mechanical thrombectomy apparatuses configured to have improved tracking for delivery through tortious vessels are described herein. Also described herein are methods of removing clots using a mechanical thrombectomy apparatuses in which the clot is larger than the tractor portion of the mechanical thrombectomy apparatus.

First claim

What is claimed is:

1 . A method of removing a clot from a vessel having an inner diameter (ID), the method comprising:
advancing an inverting tube apparatus through the vessel until a distal end of the inverting tube apparatus is proximate to a clot, wherein the inverting tube apparatus comprises an inversion support catheter, a puller within a lumen of the support catheter, and a knitted tube having a first end coupled to a distal end region of the puller, and a second end that is free to move relative to the inserting support catheter, wherein the knitted tube comprises a filament knitted to form a plurality of interlocking loop stitches, wherein each loop stitch has a stitch length; expanding the knitted tube to a first configuration along an outer surface of the inverting tube catheter to an outer diameter that between 10% and 80% of an inner diameter of the vessel for a first region of the knitted tube that is adjacent to the first end, wherein the knitted tube has a second configuration within the inverting tube catheter having an inner diameter that is greater than 30% of an inner diameter of the inversion support catheter, and wherein a second region of the knitted tube adjacent to the second end has an expanded outer diameter that is less than the expanded outer diameter of the first configuration; pulling the puller proximally within the inversion support catheter to roll the knitted tube over the distal end of the inversion support catheter so that the knitted tube inverts over a distal end of the inversion support catheter, driving the loop stitches outward from the kitted tube by between 0.5 mm and 10 mm; capturing the clot with the knitted tube; and pulling the clot proximally into the inversion support catheter.

2 . The method of claim 1 , further comprising sliding the second end along the length of the inversion support catheter when pulling the puller proximally, wherein the second end comprises a cuff having a stiffness that is greater than a region of the knitted tube adjacent to the cuff.

3 . The method of claim 1 , further comprising limiting travel of the knitted tube so that the second end does not roll and invert over the distal end of the inversion support catheter when pulling the puller proximally.

4 . The method of claim 1 , wherein advancing comprises advancing over a guidewire.

5 . The method of claim 1 , wherein expanding comprises exposing the knitted tube from out of an intermediate catheter, wherein the inversion support catheter is within a lumen of the intermediate support catheter.

6 . A method of delivering an inverting mechanical thrombectomy apparatus for removing a clot from a vessel, the method comprising:
advancing a guidewire distally through a tortious vessel toward a deployment site; and advancing a pre-loaded mechanical thrombectomy apparatus distally over the guidewire, wherein the pre-loaded mechanical thrombectomy apparatus comprises an intermediate catheter having a lumen, an inversion support catheter within a lumen of the intermediate catheter, a puller catheter within a lumen of the inversion support catheter, a flexible tube attached to a distal end region of the puller catheter and extending proximally between the intermediate catheter and the inversion support catheter, wherein advancing the pre-loaded mechanical thrombectomy apparatus comprises moving the intermediate catheter and the inversion support catheter so that a distal end of the inversion support catheter remains within the intermediate catheter while a distal end of the puller catheter and at least a portion of the flexible tube are advanced ahead of a distal end of the intermediate catheter.

7 . The method of claim 6 , further comprising advancing the intermediate catheter and the inversion support catheter together.

8 . The method of claim 6 , further comprising deploying the inverting mechanical thrombectomy apparatus adjacent to a clot.

9 . The method of claim 8 , wherein deploying comprises advancing the inversion support catheter distally and withdrawing the puller catheter so that the flexible tube inverts over a distal end opening of the inversion support catheter when the distal end of the inversion support catheter is adjacent to the clot.

10 . The method of claim 8 , further comprising withdrawing the intermediate catheter proximally to expose the flexible tube over the inversion support catheter.

11 . The method of claim 8 , further comprising applying suction through the inversion support catheter.

12 . The method of claim 8 , further comprising pulling the puller catheter proximally and drawing the clot into the inversion support catheter.

13 . The method of claim 8 , further comprising applying suction between the intermediate catheter and the inversion support catheter.

14 . A method of delivering an inverting mechanical thrombectomy apparatus for removing a clot from a vessel, the method comprising:
advancing a guidewire distally through a tortious vessel toward a deployment site; and advancing a pre-loaded mechanical thrombectomy apparatus distally over the guidewire, wherein the pre-loaded mechanical thrombectomy apparatus comprises an intermediate catheter having a lumen, an inversion support catheter within a lumen of the intermediate catheter, a puller catheter within a lumen of the inversion support catheter, a flexible tube attached to a distal end region of the puller catheter and extending proximally between the intermediate catheter and the inversion support catheter, wherein advancing the pre-loaded mechanical thrombectomy apparatus comprises moving the inversion support catheter with the puller catheter distally head of the intermediate catheter over the guidewire.

15 . The method of claim 14 , further comprising deploying the inverting mechanical thrombectomy apparatus adjacent to a clot.

16 . The method of claim 15 , wherein deploying comprises advancing the inversion support catheter distally and withdrawing the puller catheter so that the flexible tube inverts over a distal end opening of the inversion support catheter when the distal end of the inversion support catheter is adjacent to the clot.

17 . The method of claim 14 , further comprising withdrawing the intermediate catheter proximally to expose the flexible tube over the inversion support catheter.

18 . The method of claim 14 , further comprising applying suction through the inversion support catheter.

19 . The method of claim 14 , further comprising pulling the puller catheter proximally and drawing the clot into the inversion support catheter.

20 . The method of claim 14 , further comprising applying suction between the intermediate catheter and the inversion support catheter.

Assignees

• Stryker Corp

Inventors

• Wallace Michael P
• Garabedian Robert
• Leguidleguid Roy
• Greenhalgh E Skott

Classifications

• A61M25/0074

  Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable · CPC title

• A61B2017/2215

  having an open distal end · CPC title

• A61B2017/22079

  with suction of debris · CPC title

• A61B2017/22038

  with a guide wire · CPC title

• A61B2017/00867

  shape memory effect · CPC title