Methods of Reducing Hair Loss and/or Facilitating Hair Growth and/or Regrowth

Patent metadata

Field	Value
Publication number	US-2018344621-A1
Application number	US-201816050610-A
Country	US
Kind code	A1
Filing date	Jul 31, 2018
Priority date	Dec 15, 2009
Publication date	Dec 6, 2018
Grant date	—

Abstract

The present disclosure relates to methods of retarding hair loss or facilitating hair growth and/or regrowth. More specifically, the present disclosure relates to methods of using the disclosed compositions to increase the rate of terminal hair growth and/or regrowth in a mammal.

First claim

What is claimed is:

1 . A method of reducing hair loss and/or facilitating hair growth or hair regrowth comprising the steps of applying to skin of a mammal in need of such treatment a safe and effective amount of a composition comprising from about 0.1% to about 100% by weight of an admixture, comprising:
a. from about 0.01% to about 99.98% by weight of the admixture of an acid selected from the group consisting of intermediates of the Kreb cycle, non-Kreb cycle intermediate alpha-keto acid, derivatives thereof, salts thereof and mixtures thereof; b. from about 0.01% to about 99.98% by weight of the admixture of an antioxidant; and c. from about 0.01% to about 99.98% by weight of the admixture of a fatty acid mixture or fatty acid mixture source comprising at least 7 unsaturated or saturated fatty acids selected from the group consisting of butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, gadoleic acid, pentadecanoic acid, margaric acid, margaroleic acid, behenic acid, dihomolinoleic acid, arachidonic acid and lignoceric acid.

2 . The method of claim 1 , wherein the acid is an alpha-keto acid.

3 . The method of claim 1 , wherein the alpha-keto acid is selected from the group consisting of pyruvic acid, alpha-ketoglutaric acid, alpha-ketoisovaleric acid, alpha-ketoisocaproic acid, salts thereof and mixtures thereof.

4 . The method according to claim 3 , wherein the alpha-keto acid is a pyruvic acid selected from the group consisting of pyruvic acid, lithium pyruvate, sodium pyruvate, potassium pyruvate, magnesium pyruvate, calcium pyruvate, zinc pyruvate, manganese pyruvate, methyl pyruvate, salts thereof, prodrugs thereof, and mixtures thereof.

5 . The method according to claim 4 , wherein the pyruvic acid is sodium pyruvate.

6 . The method according to claim 1 , wherein the antioxidant is selected from the group consisting of a Vitamin A; a Vitamin C; a tocopherol; prodrugs of Vitamin A, prodrugs of Vitamin C, and prodrugs of Vitamin E; salts of Vitamin A, salts of Vitamin C, and salts of Vitamin E; flavonoids; polyphenols; and mixtures thereof.

7 . The method according to claim 6 , wherein the antioxidant is a Vitamin E selected from the group consisting of alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol, tocoquinone, tocotrienol, esters thereof and mixtures thereof.

8 . The method according to claim 7 , wherein the Vitamin E is selected from the group consisting of esters of tocopherol, esters of beta-tocopherol, esters of gamma-tocopherol, esters of delta-tocopherol, esters of tocoquinone, esters of tocotrienol and mixtures thereof.

9 . The method according to claim 8 , wherein the Vitamin E is selected from the group consisting of an acetate ester of tocopherol, acetate ester of beta-tocopherol, acetate ester of gamma-tocopherol, acetate ester of delta-tocopherol, acetate ester of tocoquinone, acetate ester of tocotrienol and mixtures thereof.

10 . The composition of according to claim 1 wherein the fatty acids are present in the fatty acid mixture by weight as follows: about 0.2%-0.4% butyric acid, about 0.1% caproic acid, about 0.3%-0.8% caprylic acid, about 2.2%-3.5% capric acid, about 0.9%-5.5% lauric acid, about 2.8%-8.5% myristic acid, about 0.1%-0.6% myristoleic acid, about 23.2%-24.6% palmitic acid, about 1.8%-3.0% palmitoleic acid, about 6.9%-9.9% stearic acid, about 36.0%-36.5% oleic acid, about 20%-20.6% linoleic acid, about 7.5-7.8% linolenic acid, about 1.1%-4.9% arachidic acid, and about 3.3%-6.4% gadoleic acid.

11 . The composition of according to claim 1 wherein the fatty acids are present in the fatty acid mixture by weight as follows: about 0.3% myristic acid, about 19% palmitic acid, about 0.5% palmitoleic acid, about 13% stearic acid, about 44.4% oleic acid, about 21.3% linoleic acid, and about 0.5% linolenic acid.

12 . The method according to claim 1 , being in the form of a suitable topical carrier.

13 . The method according to claim 12 , wherein the topical carrier is in the form of an ointment, paste, gel, jelly, serum, aerosol spray, non-aerosol spray, foam, cream, lotion, solution, suspension.

14 . The method according to claim 13 , wherein the composition is in the form of a lotion or suspension.

15 . A method of reducing hair loss and/or facilitating hair growth or hair regrowth comprising the steps of applying to the scalp of a mammal in need of such treatment a safe and effective amount of a composition comprising from about 5% to about 50% of an admixture, comprising:
a. from about 0.01% to about 99.98% by weight of the admixture of an acid selected from the group consisting of pyruvic acid, a salt thereof and mixtures thereof; b. from about 0.01% to about 99.98% by weight of the admixture of a tocopherol or a ester thereof; and c. from about 0.01% to about 99.98% by weight of the admixture of a fatty acid mixture source, the fatty acid mixture source being an oil mixture comprising:
i. from about 0.01% to about 99.98% by weight of the fatty acid mixture of olive oil;
ii. from about 0.01% to about 99.98% by weight of the fatty acid mixture of cocoa butter; and
iii. from about 0.01% to about 99.98% by weight of the fatty acid mixture of cottonseed oil.

16 . A method of reducing hair loss and/or facilitating hair growth or hair regrowth comprising the steps of applying to the scalp of a mammal in need of such treatment a safe and effective amount of a composition comprising from about 5% to about 50% by weight of an admixture, comprising:
a. from about 20% to about 70% by weight of the admixture of an acid selected from the group consisting of pyruvic acid, a salt thereof and mixtures thereof; b. from about 20% to about 70% by weight of the admixture of an antioxidant; and c. from about 20% to about 70% by weight of the admixture of a fatty acid mixture or fatty acid mixture source
wherein the ratio of the pyruvic acid component to the fatty acid mixture is from 0.01:1 (or about 0.01:1) to 1:0.01 (about 1:0.01); the ratio of the pyruvic acid component to the antioxidant component is from 0.01:1 (or about 0.01:1) to 1:0.01 (or about 1:1.01); and the ratio of the fatty acid mixture component to the antioxidant component is from 0.01:1 (or about 0.01:1) to 1:0.01 (or about 1:0.01).

17 . The method of claim 16 , wherein the ratio of the pyruvic acid component or the fatty acid component to the antioxidant component is from 1:1 to 1:0.5.

18 . A hair growth composition, comprising:
a. optionally, a safe and effective amount of at least one hair regrowth active; b. from 5% to 10%, by weight of the composition of an acid; c. from 5% to 10%, by weight of the composition of an antioxidant; and d. from 5% to 10%, by weight of the composition of a fatty acid mixture or fatty acid mixture source, the fatty acid mixture or fatty acid mixture source being an oil mixture comprising:
i) from 0.01% to 99.98%, by weight of the fatty acid mixture of a first oil;
ii) from 0.01% to 99.98%, by weight of the fatty acid mixture of a second oil; and
iii) from 0.01% to 99.98%, by weight of the fatty acid mixture of a third oil.

19 . A hair regrowth composition, comprising
a. a safe and effective amount of at least one hair growth active; and b. from about 0.1% to about 99% of an admixture, comprising:
i. from about 0.01% to about 99.98% by weight of the admixture of an acid selected from

Assignees

• Johnson & Johnson Consumer Inc

Inventors

• Hu Longsheng
• Goldman Virginia Streusand
• Minerva Josephine A
• Wendling Susan

Classifications

• A61K8/678

  Tocopherol, i.e. vitamin E · CPC title

• A61P17/04

  Antipruritics · CPC title

• A61K31/505

  Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim · CPC title

• A61K8/365

  Hydroxycarboxylic acids; Ketocarboxylic acids · CPC title

• A61K2800/592

  Mixtures of compounds complementing their respective functions · CPC title