Preparation and use of silver sulfadiazine-immobilized fillers

Patent metadata

Field	Value
Publication number	US-2018125763-A1
Application number	US-201615571491-A
Country	US
Kind code	A1
Filing date	May 18, 2016
Priority date	May 15, 2015
Publication date	May 10, 2018
Grant date	—

Abstract

Silver sulfadiazine-immobilized inorganic fillers are described, and their synthesis is presented. The fillers are believed to have utility in dental composites and dental adhesives to achieve potent, long-term, and none-leaching antimicrobial effects.

First claim

What is claimed is:

1 . A composition of matter, comprising:
a particulate substrate comprising an inorganic filler; an amine-terminated hydrocarbon molecule moiety covalently bonded by way of a carbon atom of said hydrocarbon molecule moiety to said inorganic filler; a cyanuric chloride molecule moiety bonded to an amine group of said amine-terminated hydrocarbon molecule moiety; a sulfadiazine molecule moiety bonded to said cyanuric chloride molecule moiety; and a silver metal ion incorporated in said sulfadiazine moiety.

2 . The composition of matter of claim 1 , wherein a second sulfadiazine molecule moiety is bonded to said cyanuric chloride molecule moiety.

3 . The composition of matter of claim 2 , wherein said second sulfadiazine molecule moiety has a second silver metal ion incorporated therein.

4 . The composition of matter of claim 1 , wherein said particulate substrate comprising an inorganic filler is a particulate glass substrate.

5 . The composition of matter of claim 4 , wherein said particulate glass substrate comprises a glass containing BaO.

6 . The composition of matter of claim 1 , wherein said amine-terminated hydrocarbon molecule moiety is (3-aminopropyl)trimethoxysilane.

7 . A method of producing a composition of matter, comprising the steps of:
providing a particulate substrate comprising an inorganic filler; reacting said inorganic filler with an amine-terminated hydrocarbon molecule moiety to covalently bond said hydrocarbon molecule moiety by way of a carbon atom thereof to said inorganic filler to produce an amine modified substrate; reacting said amine modified substrate with a cyanuric chloride molecule moiety to bond said cyanuric chloride molecule moiety to an amine group of said amine-terminated hydrocarbon molecule moiety to produce an amine modified substrate-CyCl composition; reacting said amine modified substrate-CyCl composition with a sulfadiazine molecule moiety to bond an amine moiety of said sulfadiazine molecule moiety to said cyanuric chloride molecule moiety by displacing a chlorine atom thereof to produce an amine modified substrate-CyCl-SD composition; and reacting said amine modified substrate-CyCl-SD composition with a silver metal ion to incorporate said silver metal ion in said sulfadiazine moiety to produce a silver sulfadiazine-immobilized inorganic filler material.

8 . The method of producing a composition of matter of claim 7 , wherein said particulate substrate is a particulate glass substrate.

9 . The method of producing a composition of matter of claim 7 , wherein said step of reacting said inorganic filler with an amine-terminated hydrocarbon molecule moiety is performed using a reaction medium comprising cyclohexane and n-propyl amine.

10 . The method of producing a composition of matter of claim 7 , wherein said step of reacting said amine modified substrate with a cyanuric chloride molecule moiety is performed in a reaction medium comprising Na 2 CO 3 , acetone and water.

11 . The method of producing a composition of matter of claim 7 , wherein said step of reacting said amine modified substrate-CyCl composition with a sulfadiazine molecule moiety is performed using DMSO, Na 2 CO 3 and water.

12 . The method of producing a composition of matter of claim 7 , wherein said step of reacting said amine modified substrate-CyCl-SD composition with a silver metal ion is performed in a reaction medium of DI water.

13 . A method of using a composition of matter, comprising the steps of:
providing a composition of matter comprising a silver sulfadiazine-immobilized inorganic filler; mixing said composition of matter comprising a silver sulfadiazine-immobilized inorganic filler with a dental composite or dental adhesive formulation to produce a mixture; and applying said mixture as a replacement material for at least a part of a tooth in a mouth of a patient.

14 . The method of using a composition of matter of claim 13 , wherein said silver sulfadiazine-immobilized inorganic filler comprises a particulate glass substrate.

15 . The method of using a composition of matter of claim 14 , wherein said particulate glass substrate comprises BaO.

16 . The method of using a composition of matter of claim 13 , wherein said silver sulfadiazine-immobilized inorganic filler comprises an amine-terminated hydrocarbon molecule moiety.

17 . The method of using a composition of matter of claim 16 , wherein said silver sulfadiazine-immobilized inorganic filler comprises a cyanuric chloride molecule moiety bonded to an amine group of said amine-terminated hydrocarbon molecule moiety.

18 . The method of using a composition of matter of claim 17 , wherein said silver sulfadiazine-immobilized inorganic filler comprises an amine moiety of a sulfadiazine molecule moiety to said cyanuric chloride molecule moiety.

19 . The method of using a composition of matter of claim 18 , wherein said silver sulfadiazine-immobilized inorganic filler comprises a silver metal ion incorporated in said sulfadiazine moiety.

Assignees

• Univ Massachusetts

Inventors

• Srivastava Rohit
• Sun Yuyu

Classifications

• A61K6/69

  Medicaments · CPC title

• A61K6/71

  Fillers · CPC title

• C03C17/28 Primary

  with organic material (C03C17/34, C03C17/44 take precedence) · CPC title

• A61K6/54 Primary

  Filling; Sealing · CPC title

• A61K6/844

  Noble metals · CPC title