Anti-adhesion material and substitute biomembrane using decellularized tissue

Patent metadata

Field	Value
Publication number	US-2018078679-A1
Application number	US-201615556776-A
Country	US
Kind code	A1
Filing date	Mar 7, 2016
Priority date	Mar 12, 2015
Publication date	Mar 22, 2018
Grant date	—

Abstract

An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.

First claim

1 . An anti-adhesion material comprising decellularized tissues and a biocompatible polymer.

2 . The anti-adhesion material of claim 1 wherein the decellularized tissues are the ones prepared by decellularizing biological tissues selected from the group consisting of pericardium, bladder, amnion, dura mater, peritoneum, diaphragm, fascia, small intestine submucosa and skin.

3 . The anti-adhesion material of claim 1 or claim 2 wherein the decellularized tissues are the ones prepared by treating biological tissues with a high hydrostatic pressure or with a surfactant.

4 . The anti-adhesion material of claim 3 wherein the treatment with a high hydrostatic pressure comprises applying a hydrostatic pressure of 50 to 1,500 MPa to biological tissues in a medium.

5 . The anti-adhesion material of any one of claim 1 to claim 4 wherein the biocompatible polymer is a biocompatible polymer which naturally occurs.

6 . The anti-adhesion material of any one of claim 1 to claim 5 wherein the biocompatible polymer is fibrin glue.

7 . The anti-adhesion material of any one of claim 1 to claim 6 wherein the biocompatible polymer is complexed to the decellularized tissues.

8 . The anti-adhesion material of claim 7 wherein the complexation of the biocompatible polymer to the decellularized tissues is immersion or coating of the biocompatible polymer to the decellularized tissues.

9 . The anti-adhesion material of any one of claim 1 to claim 8 wherein the anti-adhesion material is an anti-adhesion membrane and a film thickness is 10 to 5,000 μm.

10 . A method for preparing an anti-adhesion material comprising complexing a biocompatible polymer to decellularized tissues.

11 . The method of claim 10 wherein the complexation is immersion or coating of the biocompatible polymer to the decellularized tissues.

12 . An anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer.

13 . The kit of claim 12 wherein the decellularized tissues are the ones prepared by decellularizing biological tissues selected from the group consisting of pericardium, bladder, amnion, dura mater, peritoneum, diaphragm, fascia, small intestine submucosa and skin.

14 . The kit of claim 12 or claim 13 wherein the decellularized tissues are the ones prepared by treating biological tissues with a high hydrostatic pressure or with a surfactant.

15 . The kit of claim 14 wherein the treatment with a high hydrostatic pressure comprises applying a hydrostatic pressure of 50 to 1,500 MPa to biological tissues in a medium.

16 . The kit of any one of claim 12 to claim 15 wherein the biocompatible polymer is fibrin glue.

17 . The kit of any one of claim 12 to claim 16 wherein the biocompatible polymer is complexed to the decellularized tissues.

18 . The kit of claim 17 wherein the complexation of the biocompatible polymer to the decellularized tissues is immersion or coating of the biocompatible polymer to the decellularized tissues.

19 . The kit of any one of claim 12 to claim 18 wherein the anti-adhesion material is an anti-adhesion membrane and a film thickness is 10 to 5,000 μm.

20 . A substitute biomembrane comprising decellularized tissues and a biocompatible polymer.

21 . The substitute biomembrane of claim 20 wherein the decellularized tissues are the ones prepared by decellularizing biological tissues selected from the group consisting of pericardium, bladder, amnion, dura mater, peritoneum, diaphragm, fascia, small intestine submucosa and skin.

22 . The substitute biomembrane of claim 20 or claim 21 wherein the decellularized tissues are the ones prepared by treating biological tissues with a high hydrostatic pressure or with a surfactant.

23 . The substitute biomembrane of claim 22 wherein the treatment with a high hydrostatic pressure comprises applying a hydrostatic pressure of 50 to 1,500 MPa to biological tissues in a medium.

24 . The substitute biomembrane of any one of claim 20 to claim 23 wherein the biocompatible polymer is a biocompatible polymer which naturally occurs.

25 . The substitute biomembrane of any one of claim 20 to claim 23 wherein the biocompatible polymer is fibrin glue.

26 . The substitute biomembrane of any one of claim 20 to claim 25 wherein the biocompatible polymer is complexed to the decellularized tissues.

27 . The substitute biomembrane of claim 26 wherein the complexation of the biocompatible polymer to the decellularized tissues is immersion or coating of the biocompatible polymer to the decellularized tissues.

28 . The kit of any one of claim 20 to claim 27 wherein a film thickness is 10 to 5,000 μm.

29 . A method for preparing a substitute biomembrane comprising complexing a biocompatible polymer to decellularized tissues.

30 . The method of claim 29 wherein the complexation is immersion or coating of the biocompatible polymer to the decellularized tissues.

31 . A substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer.

32 . The kit of claim 31 wherein the decellularized tissues are the ones prepared by decellularizing biological tissues selected from the group consisting of pericardium, bladder, amnion, dura mater, peritoneum, diaphragm, fascia, small intestine submucosa and skin.

33 . The kit of claim 31 or claim 32 wherein the decellularized tissues are the ones prepared by treating biological tissues with a high hydrostatic pressure or with a surfactant.

34 . The kit of claim 33 wherein the treatment with a high hydrostatic pressure comprises applying a hydrostatic pressure of 50 to 1,500 MPa to biological tissues in a medium.

35 . The kit of any one of claim 31 to claim 34 wherein the biocompatible polymer is fibrin glue.

36 . The kit of any one of claim 31 to claim 35 wherein the biocompatible polymer is complexed to the decellularized tissues.

37 . The kit of claim 36 wherein the complexation of the biocompatible polymer to the decellularized tissues is immersion or coating of the biocompatible polymer to the decellularized tissues.

38 . The kit of any one of claim 31 to claim 37 wherein a film thickness of the substitute biomembrane is 10 to 5,000 μm.

Assignees

• The Chemo Sero Therapeutic Res Institute
• Adeka Corp
• Univ Nat Corp Tokyo Medical & Dental
• Univ Sapporo Medical

Inventors

• Saga Hideki
• Uchida Takanori
• Tokorozaki Shoko
• Hiwatari Ken-Ichiro
• Obara Haruki
• Kishida Akio
• Kimura Tsuyoshi
• Negishi Jun
• Higami Tetsuya
• Funamoto Seiichi

Classifications

• A61L2300/424

  Anti-adhesion agents · CPC title

• A61L31/046 Primary

  Fibrin; Fibrinogen · CPC title

• A61L24/106

  Fibrin; Fibrinogen · CPC title

• A61L31/005

  Ingredients of undetermined constitution or reaction products thereof · CPC title

• A61L31/10

  Macromolecular materials · CPC title