Microtubes and methods of producing same

Patent metadata

Field	Value
Publication number	US-2017175296-A1
Application number	US-201715446228-A
Country	US
Kind code	A1
Filing date	Mar 1, 2017
Priority date	Oct 5, 2006
Publication date	Jun 22, 2017
Grant date	—

Abstract

A method of producing a microtube is provided. The method comprising co-electrospinning two polymeric solutions through co-axial capillaries to thereby produce the microtube, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution. Also provided are electrospun microtubes

First claim

1 . A method of producing a microtube, the method comprising: co-electrospinning two polymeric solutions through co-axial capillaries to thereby produce the microtube, wherein a first polymeric solution of said two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of said two polymeric solutions is for forming a coat over an internal surface of said shell, said first polymeric solution is selected solidifying faster than said second polymeric solution and a solvent of said second polymeric solution is selected incapable of dissolving said first polymeric solution.

2 . The method of claim 1 , wherein said co-electrospinning comprises a one-step co-electrospinning for producing the microtube

3 . The method of claim 1 , wherein a solvent of said first polymeric solution evaporates faster than a solvent of said second polymeric solution.

4 . The method of claim 1 , wherein said electrospinning is effected using a rotating collector.

5 . The method of claim 1 , wherein a solvent of said second polymeric solution is capable of evaporating through said internal surface of said shell.

6 . The method of claim 1 , wherein said second polymeric solution is capable of wetting said internal surface of said shell.

7 . The method of claim 1 , wherein a thickness of said shell is from about 100 nm to about 20 micrometer.

8 . The method of claim 1 , wherein an internal diameter of the microtube is from about 50 nm to about 20 micrometer.

9 . The method of claim 1 , wherein The method of claim 1 , wherein said second polymeric solution comprises a surface active polymer.

10 . The method of claim 1 , wherein said first polymeric solution comprises polyethylene glycol (PEG).

11 . The method of claim 1 , wherein said shell comprises pores.

12 . The method of claim 1 , wherein said microtube is filled with a liquid.

13 . The method of claim 12 , wherein said liquid is blood.

14 . The method of claim 1 , wherein said first and said second polymeric solutions are biocompatible.

15 . The method of claim 1 , wherein said first polymeric solution comprises a polymer selected from the group consisting of poly (e-caprolactone) (PCL), polyamide, poly(siloxane), poly(silicone), poly(ethylene), poly(vinyl pyrrolidone), poly(2-hydroxy ethylmethacrylate), poly(N-vinyl pyrrolidone), poly(methyl methacrylate), poly(vinyl alcohol), poly(acrylic acid), poly(vinyl acetate), polyacrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polylactide, polyglycolide, poly(lactide-coglycolide), polyanhydride, polyorthoester, poly(carbonate), poly(acrylo nitrile), poly(ethylene oxide), polyaniline, polyvinyl carbazole, polystyrene, poly(vinyl phenol), polyhydroxyacid, poly(caprolactone), polyanhydride, polyhydroxyalkanoate, polyurethane, collagen, albumin, alginate, chitosan, starch and hyaluronic acid

16 . The method of claim 1 , wherein said second polymeric solution comprises a polymer selected from the group consisting of poly(acrylic acid), poly(vinyl acetate), polyacrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polylactide polyglycolide, poly(lactide-coglycolide), polyanhydride, polyorthoester, poly(carbonate), poly(ethylene oxide), polyaniline, polyvinyl carbazole, polystyrene, poly(vinyl phenol), polyhydroxyacid, alginate, starch and hyaluronic acid.

17 . A microtube produced according to the method of claim 1 .

Assignees

• Technion Res & Dev Foundation

Inventors

• Zussman Eyal
• Dror Yael
• Salalha Wael
• Avrahami Ron

Classifications

• D01F8/04

  from synthetic polymers · CPC title

• D10B2509/00

  Medical; Hygiene · CPC title

• Y10T428/2935

  Discontinuous or tubular or cellular core · CPC title

• A61L27/507

  for artificial blood vessels (apparatus for applying cells on a blood vessel prosthesis A61F2/062) · CPC title

• A61L27/34

  Macromolecular materials · CPC title