Multi-layered polymer film for sustained release of agents
US-2024226394-A1 · Jul 11, 2024 · US
US9163333B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9163333-B2 |
| Application number | US-201213548956-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 13, 2012 |
| Priority date | Jul 15, 2011 |
| Publication date | Oct 20, 2015 |
| Grant date | Oct 20, 2015 |
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A method for making a graft layer is provided. The graft layer has at least two layers with different porosities. The two layers are applied by electrospinning. The parameters of the electrospinning may be varied when applying the first and second layers in order to achieve different porosities of the first and second layers.
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We claim: 1. A method of making a stent-graft with an inner layer and an outer layer where the outer layer is less porous than the inner layer, comprising: applying a first charge to a mandrel; applying a second charge to a first needle; rotating and translating said mandrel and said first needle relative to each other; dispensing a first polymer mixed with a first solvent through said first needle at a first flow rate, a first layer of fibers thereby being electrospun onto…
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