Botanical Extracts and Compounds from Schinus Plants and Methods of Use

Patent metadata

Field	Value
Publication number	US-2017007652-A1
Application number	US-201615205493-A
Country	US
Kind code	A1
Filing date	Jul 8, 2016
Priority date	Jul 10, 2015
Publication date	Jan 12, 2017
Grant date	—

Abstract

This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the fruit of a Schinus plant. In certain embodiments, the disclosure relates to methods of treating or preventing bacterial infections, acne, and other related uses.

First claim

1 . An extract comprising a fruit derived mixture of compounds from a Schinus plant wherein the extracting process comprises the steps of:
mixing a fruit with methanol under conditions such that fruit compounds dissolves in the methanol and removing the methanol providing a methanol derived mixture of compounds, partitioning the methanol derived mixture of compounds in hexane and water providing a water derived mixture of compounds, partitioning the methanol derived mixture of compounds in ethyl acetate and water providing a second water derived mixture of compounds, partitioning the water derived mixture of compounds by mixing the second water derived mixture of compounds with n-butanol under conditions such that fruit compounds dissolve in the n-butanol and removing the n-butanol providing an n-butanol derived mixture of compounds; and purifying the n-butanol derived mixture of compounds by liquid chromatography through silica.

2 . The extract of claim 1 wherein the mixture comprises at least one component from each of the following groups a) to d):
a) a compound having a molecular formula of C 30 H 17 O 10 ;
b) a compound having a molecular formula of C 30 H 21 O 10 ;
c) a compound having a molecular formula of C 30 H 45 O 4 ; and
d) a compound having a molecular formula of C 30 H 45 O 4 .

3 . A pharmaceutical or cosmetic formulation comprising the extract or one or more compounds in the extract of claim 1 and a pharmaceutically acceptable excipient or cosmetically acceptable excipient.

4 . A liquid or gel formulation of claim 3 , optionally further comprising an antibiotic agent, a topical steroid, an anti-inflammatory agent, a promoter of skin barrier function, a skin moisturizer or combinations thereof.

5 . The formulation of claim 3 comprising an enteric coating.

6 . A solid or liquid soap or lotion comprising the extract or one or more compounds in the extract of claim 1 and a fatty acid.

7 . A medical device comprising a coating comprising the extract or one or more compounds in the extract of claim 1 .

8 . A wound dressings or wound rinse comprising the extract or one or more compounds in the extract of claim 1 wherein the wound dress comprises an absorbent pad and optionally an adhesive.

9 . A tampon comprising the extract or one or more compounds in the extract of claim 1 wherein the tampon comprises an absorbent material.

10 . A method of treating or preventing a bacterial infections comprising administering or contacting a formula comprising the extract or one or more compounds in the extract as in claim 1 to a subject in need thereof.

11 . The method of claim 10 , wherein the subject is at risk of, exhibiting symptoms of, or diagnosed with toxic shock syndrome, scalded skin syndrome, abscesses, furuncles, cellulitis, folliculitis, bloodstream infections, medical device infections, pneumonia, osteomyelitis, staphylococcal food poisoning, skin and soft tissue infections, endocarditis, eczema, atopic dermatitis, psoriasis, impetigo, septic arthritis, brain abscess, burn wounds, venous ulcers, diabetic foot ulcers, surgical wounds, post-operation infections, carbuncles, meningitis, bacteremia, necrotizing pneumonia, or necrotizing fasciitis.

12 . The method of claim 11 , wherein the formula is administered in combination with an antibiotic agent.

13 . A method of treating acne comprising administering a composition comprising an extract the extract or one or more compounds in the extract as in claim 1 to a subject at risk of, exhibiting symptoms of, or diagnosed with abnormal acne.

Assignees

• Univ Emory

Inventors

• Quave Cassandra L
• Lyles James

Classifications

• A61P17/10

  Anti-acne agents · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K2236/33

  involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones · CPC title

• A61L15/40

  containing ingredients of undetermined constitution or reaction products thereof {, e.g. plant or animal extracts} · CPC title

• A61K2236/39

  Complex extraction schemes, e.g. fractionation or repeated extraction steps · CPC title