Silicone hydrogel lenses with water-rich surfaces

Patent metadata

Field	Value
Publication number	US-2016377885-A1
Application number	US-201615202759-A
Country	US
Kind code	A1
Filing date	Jul 6, 2016
Priority date	Jul 30, 2010
Publication date	Dec 29, 2016
Grant date	—

Abstract

The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

First claim

1 - 64 . (canceled)

65 . A hydrated silicone hydrogel contact lens, comprising:
a silicone hydrogel material comprising repeating units of a polysiloxane-containing vinylic monomer and repeating units of a hydrophilic vinylic monomer; and an opposite posterior surface, wherein the hydrated silicone hydrogel contact lens has an oxygen transmissibility of at least about 40 barrers/mm, a water content of from about 10% to about 75% by weight, an elastic modulus of from about 0.3 MPa to about 1.8 MPa, a surface wettability characterized by having an averaged water contact angle of about 80 degrees or less, and a surface hydrophilicity characterized by having a WBUT of at least about 10 seconds, wherein the hydrated silicone hydrogel contact lens has a cross-sectional surface-modulus profile which comprises, along a shortest line between the anterior and posterior surfaces on the surface of a cross section of the hydrated silicone hydrogel contact lens, an anterior outer zone including and near the anterior surface, an inner zone including and around the center of the shortest line, and a posterior outer zone including and near the posterior surface, wherein the anterior outer zone has an average anterior surface modulus (designated as SM Ant ) while the posterior outer zone has an average posterior surface modulus (designated as SM Post ), wherein the inner zone has an average inner surface modulus (designated as SM Inner ), wherein at least one of

SM
Inner

_

-

SM
Post

_

SM
Inner

_

×
100

%



and




SM
Inner

_

-

SM
Ant

_

SM
Inner

_

×
100

%

is at least about 20%, wherein the anterior and posterior outer zones covers a span of at least about 0.1 μm.

66 . The hydrated silicone hydrogel contact lens of claim 65 , wherein the anterior and posterior outer zones covers a span of from about 0.25 μm to about 15 μm.

67 . The hydrated silicone hydrogel contact lens of claim 65 , wherein the anterior and posterior outer zones covers a span of from about 0.5 μm to about 12.5 μm.

68 . The hydrated silicone hydrogel contact lens of claim 65 , wherein the anterior and posterior outer zones covers a span of from about 1 μm to about 10 μm.

69 . The hydrated silicone hydrogel contact lens of claim 65 , wherein the hydrated silicone hydrogel contact lens has an oxygen transmissibility of at least about 60 barrers/mm.

70 . The hydrated silicone hydrogel contact lens of claim 69 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 70 degrees or less.

71 . The hydrated silicone hydrogel contact lens of claim 69 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 60 degrees or less.

72 . The hydrated silicone hydrogel contact lens of claim 69 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 50 degrees or less.

73 . The hydrated silicone hydrogel contact lens of claim 66 , wherein the hydrated silicone hydrogel contact lens has an oxygen transmissibility of at least about 60 barrers/mm.

74 . The hydrated silicone hydrogel contact lens of claim 73 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 70 degrees or less.

75 . The hydrated silicone hydrogel contact lens of claim 73 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 60 degrees or less.

76 . The hydrated silicone hydrogel contact lens of claim 73 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 50 degrees or less.

77 . The hydrated silicone hydrogel contact lens of claim 67 , wherein the hydrated silicone hydrogel contact lens has an oxygen transmissibility of at least about 60 barrers/mm.

78 . The hydrated silicone hydrogel contact lens of claim 77 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 70 degrees or less.

79 . The hydrated silicone hydrogel contact lens of claim 77 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 60 degrees or less.

80 . The hydrated silicone hydrogel contact lens of claim 77 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 50 degrees or less.

81 . The hydrated silicone hydrogel contact lens of claim 68 , wherein the hydrated silicone hydrogel contact lens has an oxygen transmissibility of at least about 60 barrers/mm.

82 . The hydrated silicone hydrogel contact lens of claim 81 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 70 degrees or less.

83 . The hydrated silicone hydrogel contact lens of claim 81 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 60 degrees or less.

84 . The hydrated silicone hydrogel contact lens of claim 81 , wherein the hydrated silicone hydrogel contact lens has a surface wettability characterized by having an averaged water contact angle of about 50 degrees or less.

85 . The hydrated silicone hydrogel contact lens of claim 65 , wherein at least one of

SM
Inner

_

-

SM

Assignees

• Novartis Ag

Inventors

• Qiu Yongxing
• Pruitt John Dallas
• Thekveli Sibichen J
• Tucker Robert Carey
• Nelson Jared

Classifications

• G02C7/04

  Contact lenses for the eyes (disinfection or sterilisation of contact lenses A61L12/00) · CPC title

• B29D11/00067 Primary

  Hydrating contact lenses · CPC title

• G02C7/049 Primary

  Contact lenses having special fitting or structural features achieved by special materials or material structures · CPC title

• G02C2202/16

  Laminated or compound lenses · CPC title

• G02C2202/06

  Special ophthalmologic or optometric aspects · CPC title