Pulse photodynamic treatment of skin conditions

Patent metadata

Field	Value
Publication number	US-2016346392-A1
Application number	US-201415103656-A
Country	US
Kind code	A1
Filing date	Dec 19, 2014
Priority date	Dec 20, 2013
Publication date	Dec 1, 2016
Grant date	—

Abstract

A pulse photodynamic therapy (or pulse PDT) treatment of skin complaints is described herein. The skin complaint being treated can be actinic keratosis (AK) or a basal cell carcinoma (BCC).

First claim

1 . A method of treating a skin condition in an animal the method comprising adminisering a photosensitizer to the animal skin, wherein the photosensitizer treats the skin condition with photodynamic therapy (PDT), and wherein the photosensitizer is applied to the skin of the animal for a short period of time, and the skin condition is actinic keratosis or basal cell carcinoma.

2 . The method according to claim 1 , wherein the method reduces side effects associated with PDT.

3 . The method according to claim 1 , further comprising applying the photosensitizer to the skin of the animal for a period of from 5 minutes to 120 minutes.

4 . The method according to claim 1 , wherein the PDT includes a photoactivation achieved by artificial or natural light source.

5 . The method according to claim 1 , wherein the PDT comprises:
a) administering to the animal a composition comprising the photosensitizer for a duration of from 5 minutes to 120 minutes; and b) photoactivating the photosensitizer for a duration of from 1 minute to 15 minutes with artificial light or from 0.5 hour to 3 hours with natural light.

6 . The method according to claim 5 , wherein the PDT comprises:
a) administering to the animal a composition comprising the photosensitizer for a duration of from 15 minutes to 60 minutes; and b) photoactivating the photosensitizer for a duration of from 5 minutes to 10 minutes with artificial light or from 0.5 hour to 2 hours with natural light.

7 . The method according to claim 6 , wherein PDT comprises:
a) administering to the animal a composition comprising the photosensitizer for a duration of 30 minutes; and b) removing the photosensitizer; and c) photoactivating the photosensitizer 2.5 hours later for a duration of 9 minutes with artificial light or of at least 2 hours with natural light.

8 . The method according to claim 1 , wherein the photosensitizer is selected from the group consisting of 5-ALA, 5-ALA derivatives, 5-MAL, 5-MAL derivatives, and compounds covered by general formula I:
R 2 2 N—CH 2 COCH 2 —CH 2 CO—OR 1   (I)
wherein: R 1 represents a substituted or unsubstituted straight, branched or cyclic alkyl group; and each R 2 independently represents a hydrogen atom or an optionally substituted alkyl group; and pharmaceutically acceptable salts thereof.

9 . The method according to claim 1 , wherein the photosensitizer is 5-ALA or 5-methyl ALA ester.

10 . The method according to claim 1 , wherein administering the photosensitizer to the animal is carried out with or without occlusion.

11 . The method according to claim 1 , wherein the photosensitizer is used in combination with a glucocorticosteroid.

12 . The method according to claim 3 , wherein the period of time is from 15 minutes to 60 minutes.

13 . The method according to claim 4 , wherein the artificial or natural light source is a LED or sunlight.

14 . The method according to claim 8 , wherein the alkyl group is a substituted or unsubstituted straight-chained alkyl group.

15 . The method according to claim 10 , wherein the administration of the photosensitizer is carried out with occlusion.

Assignees

• Galderma Res & Dev

Inventors

• Wulf Hans Christian

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61P17/16

  Emollients or protectives, e.g. against radiation · CPC title

• A61P17/10

  Anti-acne agents · CPC title