Pulse photodynamic treatment of photodamaged skin

Patent metadata

Field	Value
Publication number	US-2016287701-A1
Application number	US-201415103603-A
Country	US
Kind code	A1
Filing date	Dec 5, 2014
Priority date	Dec 20, 2013
Publication date	Oct 6, 2016
Grant date	—

Abstract

A pulse photodynamic therapy (or pulse PDT) treatment of photodamaged skin is described.

First claim

1 . A method of treating photodamaged skin of an animal, the method comprising applying a photosensitizer to the skin of the animal, wherein the photosensitizer treats the photodamaged skin by photodynamic therapy (PDT), and wherein the photosensitizer is applied to the skin of the animal after a pretreatment of the skin.

2 . The method according to claim 1 , wherein the photosensitizer is applied for a duration of 4 minutes to 4 hours.

3 . The method according to claim 1 , wherein the photosensitizer is applied for a short period of time of from 5 minutes to 120 minutes.

4 . A method of treating photodamaged skin of an animal, the method comprising applying a photosensitizer to the skin of the animal, wherein the photosensitizer treats the photodamaged skin by photodynamic therapy (PDT), and wherein the photosensitizer is applied for a short period of time of 5 minutes to 120 minutes.

5 . The method according to claim 1 , wherein the method reduces side effects associated with PDT.

6 . The method according to claim 1 , wherein the PDT includes a photoactivation achieved by a natural light source.

7 . The method according to claim 6 , wherein the photodynamic therapy includes a photoactivation for a duration of from 0.5 hour to 3 hours with the natural light source.

8 . The method according to claim 1 , wherein the PDT comprises:
a) subjecting the skin of the animal to a pretreatment; b) administering to the animal a composition comprising the photosensitizer for a duration of from 5 minutes to 120 minutes; and c) photoactivating the photosensitizer for a duration of from 0.5 hour to 3 hours with natural light.

9 . The according to claim 1 , wherein the PDT comprises:
a) subjecting the skin of the animal to a pretreatment; b) administering to the animal a composition comprising the photosensitizer for a duration of about 30 minutes; and c) removing the photosensitizer; and d) photoactivating the photosensitizer 2.5 hours later for a duration of at least 2 hours with natural light.

10 . The method according to claim 1 , wherein the photosensitizer is selected from the group consisting of 5-ALA, 5-ALA derivatives, 5-MAL, 5-MAL derivatives, and compounds covered by general formula I:
R 2 2 N—CH 2 COCH 2 —CH 2 CO—OR 1   (I)
wherein: R 1 represents a substituted or unsubstituted straight, branched or cyclic alkyl group; and each R 2 independently represents a hydrogen atom or an optionally substituted alkyl group; and pharmaceutically acceptable salts thereof.

11 . The method according to claim 1 , wherein the photosensitizer is 5-ALA or 5-methyl ALA ester.

12 . The method according to claim 1 , wherein the administration of the photosensitizer is carried out with or without occlusion.

13 . A kit comprising a device for implementing a mechanical or chemical pretreatment of the skin, and a composition comprising a photosensitizer that treats photodamaged skin by photodynamic therapy (PDT).

14 . The kit according to claim 13 , comprising an adapted sandpaper and a composition comprising ALA or esters of ALA.

15 . The kit according to claim 13 , further comprising a sunscreen.

16 . The method according to claim 1 , wherein the pretreatment is selected from the group consisting of dermoabrasion, microneedling, and chemical pretreatment

17 . The method according to claim 16 , wherein the chemical pretreatment is peeling.

18 . The method according to claim 2 , wherein the duration is from 15 minutes to 3 hours.

19 . The method according to claim 3 , wherein the period of time is from 15 minutes to 60 minutes.

20 . The method according to claim 3 , wherein the period of time is from 20 minutes to 40 minutes.

21 . The method according to claim 20 , wherein the period of time is selected from the group consisting of 25, 26, 27, 28, 29, 30, 31, 32, 33, 34 and 35 minutes.

22 . The method according to claim 4 , wherein the period of time is from 15 minutes to 60 minutes.

23 . The method according to claim 4 , wherein the period of time is from 20 minutes to 60 minutes.

24 . The method according to claim 23 , wherein the period of time is selected from the group consisting of 25, 26, 27, 28, 29, 30, 31, 32, 33, 34 and 35 minutes.

25 . The method according to claim 6 , wherein the natural light source is sunlight.

26 . The method according to claim 8 , wherein the pretreatment is mechanical or chemical pretreatment.

27 . The method according to claim 9 , wherein the pretreatment is mechanical or chemical pretreatment.

28 . The method according to claim 27 , wherein the pretreatment is with sandpaper.

29 . The method according to claim 9 , wherein the duration of administering the photosensitizer is selected from the group consisting of 27, 28, 29, 30, 31, and 32 minutes.

30 . The method according to claim 29 , wherein the duration is 30 minutes.

31 . The method according to claim 10 , wherein R 1 is a substituted or unsubstituted straight-chained alkyl group.

32 . The method according to claim 12 , wherein the administration is carried out with occlusion.

33 . The kit according to claim 14 , wherein the composition comprises methyl ALA ester, hexyl ALA ester or benzyl ALA ester.

34 . The kit according to claim 33 , wherein the composition comprises methyl ALA ester.

Assignees

• Galderma Res & Dev

Inventors

• Wulf Hans Christian
• Sanclemente Gloria

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61P17/10

  Anti-acne agents · CPC title