Use of photosynthesis to rebalance ischemia bioenergetics

Patent metadata

Field	Value
Publication number	US-2016310547-A1
Application number	US-201615136612-A
Country	US
Kind code	A1
Filing date	Apr 22, 2016
Priority date	Apr 24, 2015
Publication date	Oct 27, 2016
Grant date	—

Abstract

Compositions and methods are provided for photosynthetic correction of metabolic imbalances that occur in ischemic consitions. In the methods of the invention, an ischemic or potentially ischemic tissue is contacted with an effective dose of a photosynthetic system in the presence of a light source, where the dose or concentration is sufficient to increase oxygenation and simple sugar supply of the targeted tissue or organ.

First claim

What is claimed is:

1 . A method for correction of a metabolic imbalance as a result of ischemia in a mammalian tissue, the method comprising:
contacting a tissue suffering from ischemia or at risk of ischemia with effective dose of a photosynthetic system in the presence of a light source, where the dose or concentration is sufficient to increase oxygenation and simple sugar delivery at the targeted tissue or organ.

2 . The method of claim 1 , wherein the tissue is ischemia as a result of a surgical procedure.

3 . The method of claim 2 , wherein the tissue is cardiac tissue.

4 . The method of claim 2 , wherein the surgical procedure is a solid organ transplantation.

5 . The method of claim 4 , wherein the tissue is contacted with an effective dose of photosynthetic microorganisms ex vivo.

6 . The method of claim 1 , wherein the tissue is contacted with an effective dose of photosynthetic microorganisms in vivo.

7 . The method of claim 6 , wherein the effective dose of photosynthetic microorganisms is sysmetically administered.

8 . The method of claim 6 , wherein the effective dose of photosynthetic microorganisms is brought into fluid communication with the organism while isolated by a semi-permeable membrane from the tissue.

9 . The method of claim 8 , wherein the effective dose of photosynthetic microorganisms is isolated in a device.

10 . The method of claim 1 , wherein the photosynthetic system comprises photosynthetic bacteria.

11 . The method of claim 10 , wherein the bacteria is a cyanobacteria.

12 . The method of claim 11 , wherein the cyanobacteria is a Synecocchus sp.

13 . The method of claim 12 , wherein the cynabacteria is Synechoccus elongatus.

14 . The method of claim 11 , wherein the cyanobacteria is a naturally occurring organism.

15 . The method of claim 11 , wherein the cyanobacteria is genetically engineered or selected for a trait of interest.

16 . The method of claim 1 , wherein an artificial light source is provided.

17 . The method of claim 1 , wherein an articial light source is integrated into a device to isolate the microorganism.

18 . The method of claim 16 , wherein an artificial light source is operably connected to the tissue being treated.

19 . An isolated population of photosynthetic microorganisms in a dose effective for use in the methods of claim 1 .

20 . A device comprising an isolated population of photosynthetic microorganisms as set forth in claim 19 .

21 . A kit for use in the method of claim 1 .

Assignees

• Univ Leland Stanford Junior

Inventors

• Cohen Jeffrey E
• Goldstone Andrew B
• Woo Y Joseph

Classifications

• C12N1/20

  Bacteria; Culture media therefor · CPC title

• A61N5/0601

  Apparatus for use inside the body · CPC title

• A61N2005/0659

  infrared · CPC title

• A61K35/748 Primary

  Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina (algae, microalgae or microphytes A61K36/02) · CPC title

• A61N2005/067

  Human Necessities · mapped topic