Methods for preparing a skin graft without culturing or use of biologics
US-9517082-B2 · Dec 13, 2016 · US
US2016287281A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016287281-A1 |
| Application number | US-201615016954-A |
| Country | US |
| Kind code | A1 |
| Filing date | Feb 5, 2016 |
| Priority date | Dec 6, 2013 |
| Publication date | Oct 6, 2016 |
| Grant date | — |
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Systems, instruments, and methods are described in which a scalpet device comprises a housing configured to include a scalpet assembly. The scalpet assembly includes a scalpet array and one or more guide plates. The scalpet array includes a set of scalpets, and in embodiments the set of scalpets include multiple scalpets. The guide plate maintains a configuration of the set of scalpets. The set of scalpets is configured to be deployed from and retracted into the housing, and is configured to generate incised skin pixels at a target site when deployed. The incised skin pixels are harvested.
Opening claim text (preview).
What is claimed is: 1 . A system, comprising: a housing configured to include a scalpet assembly; the scalpet assembly comprising a scalpet array and at least one guide plate, wherein the scalpet array includes a plurality of scalpets, wherein the at least one guide plate maintains a configuration of the plurality of scalpets, wherein the scalpet array is configured to be deployed from and retracted into the housing, wherein the scalpet array is configured to generate a plurality of incised skin pixels at a target site when deployed; a drive system coupled to the scalpet array and configured to couple a force to the scalpet array for the generation of the plurality of incised skin pixels. 2 . The system of claim 1 , wherein the drive system is configured to apply rotational force to the scalpet array, wherein the rotational force is configured to rotate at least a set of the plurality of scalpets. 3 . The system of claim 2 , wherein the drive system comprises a geared drive system. 4 . The system of claim 3 , wherein the geared drive system comprises a gear component configured to be driven to deliver a rotational force to the scalpet array. 5 . The system of claim 4 , wherein the gear component includes a gear. 6 . The system of claim 5 , wherein each scalpet is coupled to the gear. 7 . The system of claim 5 , wherein each scalpet comprises the gear. 8 . The system of claim 2 , wherein the drive system comprises a frictional drive system. 9 . The system of claim 8 , wherein the frictional drive system is configured to generate frictional forces through a compressive component of at least a set of the plurality of scalpets, wherein the frictional forces are configured to rotate at least a set of the plurality of scalpets. 10 . The system of claim 9 , wherein the compressive component includes an elastomeric ring. 11 . The system of claim 10 , wherein each scalpet is coupled to the elastomeric ring. 12 . The system of claim 10 , wherein each scalpet comprises the elastomeric ring. 13 . The system of claim 2 , wherein the drive system comprises a helical drive system. 14 . The system of claim 13 , wherein the helical drive system comprises a push plate configured for up and down movement relative to the scalpet array. 15 . The system of claim 14 , wherein the push plate comprises a plurality of openings configured to align the plurality of scalpets, wherein at least one opening of the plurality of openings includes a notch configured to receive a helical component of at least one scalpet. 16 . The system of claim 15 , wherein the helical component includes an external thread. 17 . The system of claim 16 , wherein a scalpet is coupled to a sleeve comprising the helical component. 18 . The system of claim 16 , wherein a scalpet comprises the helical component. 19 . The system of claim 2 , wherein the drive system comprises a slotted drive system. 20 . The system of claim 19 , wherein the slotted drive system comprises a drive rod configured to couple with a slotted component of the scalpet array, wherein the drive rod is configured for up and down movement relative to the scalpet array. 21 . The system of claim 20 , wherein the slotted component includes a slot configured to receive the drive rod. 22 . The system of claim 21 , wherein each scalpet comprises the slot. 23 . The system of claim 21 , wherein each scalpet comprises a sleeve, and the sleeve comprises the slot. 24 . The system of claim 2 , wherein the drive system comprises an inner helical drive system. 25 . The system of claim 24 , wherein the inner helical drive system comprises a push plate configured for up and down movement relative to the scalpet array. 26 . The system of claim 25 , wherein the push plate comprises a plurality of openings configured to align the plurality of scalpets, wherein at least one opening of the plurality of openings is configured to receive a helical component of at least one scalpet. 27 . The system of claim 26 , wherein the helical component includes a threaded insert. 28 . The system of claim 27 , wherein a scalpet is configured to receive the helical component. 29 . The system of claim 27 , wherein a scalpet comprises the helical component. 30 . The system of claim 1 , wherein the scalpet assembly is configured to transmit an axial force to the target site. 31 . The system of claim 30 , wherein the axial force comprises a continuous axial force. 32 . The system of claim 30 , wherein the axial force comprises a continuous axial force and an impact force. 33 . The system of claim 30 , wherein the axial force comprises an impact force. 34 . The system of claim 1 , wherein at least one scalpet of the scalpet array comprises a cylindrical scalpet including a cutting surface on a distal end of the scalpet. 35 . The system of claim 34 , wherein the cutting surface includes a sharpened edge. 36 . The system of claim 34 , wherein the cutting surface includes at least one sharpened point. 37 . The system of claim 34 , wherein the cutting surface includes a serrated edge. 38 . The system of claim 34 , wherein the cutting surface includes at least one radius of curvature. 39 . The system of claim 1 , wherein at least one scalpet of the scalpet array comprises a rectangular scalpet including a cutting surface on a distal end of the scalpet. 40 . The system of claim 39 , wherein the cutting surface includes a sharpened edge. 41 . The system of claim 39 , wherein the cutting surface includes at least one sharpened point. 42 . The system of claim 39 , wherein the cutting surface includes a serrated edge. 43 . The system of claim 1 , wherein at least one scalpet of the scalpet array comprises a through orifice. 44 . The system of claim 1 , comprising an extrusion system configured to include a plurality of extrusion pins. 45 . The system of claim 44 , wherein the plurality of extrusion pins corresponds to the plurality of scalpets. 46 . The system of claim 44 , wherein each extrusion pin is aligned with a corresponding scalpet of the plurality of scalpets. 47 . The system of claim 44 , wherein the plurality of extrusion pins is configured to clear the plurality of incised skin plugs from an interior of the plurality of scalpets. 48 . The system of claim 44 , wherein the plurality of extrusion pins is configured to inject the plurality of incised skin plugs into a fractional defect at a recipient site. 49 . The system of claim 44 , wherein the plurality of extrusion pins is configured to inject the plurality of incised skin plugs into pixel canisters of a docking station. 50 . The system of claim 44 , wherein the extrusion system includes an ejector component coupled to the plurality of extrusion pins, wherein the ejector component is configured to control movement of the plurality of extrusion pins into and out of an interior region of the plura
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