Method and apparatus for grafting of skin tissue

Patent metadata

Field	Value
Publication number	US-9451979-B2
Application number	US-200913120799-A
Country	US
Kind code	B2
Filing date	Sep 24, 2009
Priority date	Sep 24, 2008
Publication date	Sep 27, 2016
Grant date	Sep 27, 2016

Abstract

Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site. The raised (removed) portions of the blisters can be removed and attached to a dressing material, and the portions from the donor (first) site can be placed onto the exposed blister areas at the recipient site.

First claim

What is claimed is:

1. An apparatus for forming a plurality of graft tissues, comprising:
a first plate forming a first surface and comprising a plurality of first holes extending from the first surface through the first plate, wherein the first holes form a pattern of holes distributed across the first surface of the first plate and the first holes are configured to be aligned to a plurality of raised portions of blisters formed in skin tissue to project through the first holes;
a second plate forming a second surface and coupled to the first plate, wherein the second plate comprises a plurality of second holes extending from the second surface through the second plate; and
a cutting arrangement provided between the first surface of the first plate and the second plate, the cutting arrangement comprising a cutting edge or blade configured to translate across the first surface of the first plate to separate the raised portions of blisters from the skin tissue at a location where the raised portions of blisters are projecting through the first holes above the first surface of the first plate.

2. The apparatus of claim 1 , wherein the second holes are configured to be provided with the raised portions of blisters when separated from the skin tissue.

3. The apparatus according to claim 1 , further comprising a suction blister apparatus configured to engage the skin tissue to form the raised portions of blisters formed in the skin tissue.

4. The apparatus according to claim 3 , wherein the suction blister apparatus is configured to engage the second plate to form a blister plate and wherein the second holes form blister holes therethrough and wherein the plurality of first holes in the first plate is the same as the plurality of blister holes formed in the blister plate, wherein the plurality of first holes in the first plate are configured to allow for the raised portions of blisters formed in skin tissue by the suction blister apparatus to project therethrough.

5. The apparatus according to claim 4 , wherein the suction blister apparatus includes a vacuum source in a pressure communication with the blister plate to deliver a suction to the blister plate configured to draw the skin tissue into the plurality of blister holes to form the raised portions.

6. An apparatus for forming a plurality of graft tissues, comprising:
a first plate comprising a plurality of first holes therethrough, wherein the first holes form a pattern of holes distributed across the first plate to be aligned to a plurality of raised portions of blisters formed in skin tissue to project therethrough;
a second plate coupled to the first plate, wherein the second plate comprises a plurality of second holes; and
a cutting arrangement provided between the first and second plates, the cutting arrangement being configured to separate the raised portions of blisters from the skin tissue when the raised portions of blisters are projected through the first holes;
further comprising a suction blister apparatus configured to engage the skin tissue to form the raised portions of blisters formed in the skin tissue; and
wherein the suction blister apparatus includes a vacuum source in a pressure communication with one of the first or the second plate.

7. An apparatus for forming a plurality of graft tissues, comprising:
a first plate forming a first surface and comprising a plurality of holes extending from the first surface through the first plate, wherein the holes form a pattern of holes distributed across the first plate;
a second plate forming a second surface and a plurality of spacers configured to arrange the first plate comprising the plurality of holes at a distance away from a surface of skin tissue to receive a plurality of raised portions of blisters formed in the skin tissue through the plurality of holes; and
a cutting arrangement configured to pass along the first surface of the first plate to separate the raised portions of blisters received through the plurality of holes from the skin tissue at a location where the raised portions of blisters are extending through the plurality of holes in the first plate and above the first surface of the first plate.

8. The apparatus according to claim 7 , further comprising a vacuum source configured to be coupled to the first plate to draw the skin tissue through the plurality of holes and form the raised portions of blisters received by the plurality of holes in the first plate.

9. The apparatus according to claim 7 , wherein the second plate is coupled to the first plate and comprises another plurality of holes that are aligned with the plurality of holes.

10. The apparatus according to claim 9 , wherein the cutting arrangement is arranged between the first plate and the second plate.

Assignees

• Asrani Falguni
• Shah Ajay
• Farinelli William
• Liu Vincent
• Anderson Richard R
• Massachusetts Gen Hospital
• Massachusetts Inst Technology

Inventors

• Asrani Falguni
• Shah Ajay
• Farinelli William
• Liu Vincent
• Anderson Richard R

Classifications

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61F2/10 Primary

  Hair or skin implants · CPC title

• A61F2/105

  Skin implants, e.g. artificial skin · CPC title

• A61B2017/00969

  used for transplantation · CPC title