System for analysis of complex rhythm disorders

Patent metadata

Field	Value
Publication number	US-2016278657-A1
Application number	US-201615177317-A
Country	US
Kind code	A1
Filing date	Jun 8, 2016
Priority date	Oct 9, 2008
Publication date	Sep 29, 2016
Grant date	—

Abstract

A system to generate a representation of a rhythm disorder includes a plurality of sensors disposed at multiple locations spatially in relation to the heart, wherein cardiac information signals are sensed. A processor receives and analyzes the activation onsets of the cardiac information signals to determine an arrangement of activation onsets. A representation that indicates the clinical source of the rhythm disorder is generated based on the arrangement of the activation onsets.

First claim

1 . A system associated with generating a representation of a heart rhythm disorder comprising:
a plurality of sensors disposed at multiple locations in relation to the heart to sense cardiac information signals; and a processor interfacing with the plurality of sensors, wherein the processor is configured to:
receive data associated with the cardiac information signals, the data comprising an activation onset of each cardiac information signal at each location such that a plurality of activation onsets at a plurality of locations is collected;
determine an arrangement of activation onsets derived from the data associated with the cardiac information signals; and
generate a sensory representation based on the arrangement of the activation onsets, wherein the sensory representation indicates a clinical source of the heart rhythm disorder.

2 . The system of claim 1 , wherein the arrangement is based on an ordering of the activation onsets.

3 . The system of claim 2 , wherein the sensory representation comprises an activation trail based on the arrangement of activation onsets as ordered.

4 . The system of claim 3 , wherein the activation trail comprises activations that revolve around or radially emanate from a core region, the core region indicative of a heart rhythm disorder.

5 . The system of claim 3 , wherein the sensory representation comprises an activation trail that is repeating.

6 . The system of claim 3 , wherein the activation trail comprises a rotational pattern or an outwardly emanating pattern.

7 . The system of claim 6 , wherein the rotational pattern or the outwardly emanating pattern is repeating.

8 . The system of claim 3 , wherein the processor is further configured to visually depict on a display device the sensory representation comprising the activation trail.

9 . The system of claim 8 , wherein the display device is arranged for visually depicting the activation onsets in relation to a location of each sensor to display the activation trail.

10 . The system of claim 3 , wherein the processor is further configured to perform:
analyzing the cardiac information signals at one or more of the multiple locations; and approximating the activation trail based on the analyzing.

11 . The system of claim 10 , wherein analyzing comprises analyzing one or more of rate, regularity, amplitude, duration, and location.

12 . The system of claim 3 , wherein the processor is further configured to determine an approximate core region in relationship to the activation trail.

13 . The system of claim 12 , wherein the activation trail revolves about the approximate core region or the activation trail emanates outwardly from the approximate core region.

14 . The system of claim 12 , wherein the approximate core region is a rotor or a focal activation.

15 . The system of claim 1 , wherein the sensory representation indicates the clinical source of the heart rhythm disorder by providing a visualization of at least one of existence, type, and location of the heart rhythm disorder.

16 . The system of claim 1 , wherein the sensory representation indicates the clinical source of the heart rhythm disorder by providing at least one of an image, textual, tactile, graphic and auditory visualization of a rotor or other cause of the heart rhythm disorder.

17 . The system of claim 1 , wherein the sensory representation is one or more of a visual display and auditory signal.

18 . The system of claim 17 , wherein the visual display includes one or more of a real-time presentation, textual data, and graphical data.

19 . The system of claim 17 , wherein the auditory signal comprises an auditory identification of the clinical source of the heart rhythm disorder.

20 . The system of claim 1 , wherein the sensory representation comprises an activation trail based on a sequential ordering of the activation onsets.

21 . The system of claim 1 , wherein the processor is further configured to generate the sensory representation based on an activation trail, the activation trail based on at least one of a direct phase, Hilbert transform, wavelet transform, phase-delay, and time-domain analysis associated with the cardiac information signals.

22 . The system of claim 1 , wherein the sensory representation is at least one of a set of data, an image, a graphic, and a textual description.

23 . The system of claim 1 , wherein the sensory representation comprises a rotational pattern or an outwardly emanating pattern.

24 . The system of claim 23 , wherein the rotational pattern or the outwardly emanating pattern is repeating.

25 . The system of claim 1 , wherein one or more of the multiple locations are within the heart or proximal to the heart.

26 . The system of claim 1 , further comprising a sensor device to sense the cardiac information signals at the multiple locations using the plurality of sensors.

27 . The system of claim 26 , wherein the sensor device performs sensing of the cardiac information signals at the multiple locations concurrently.

28 . The system of claim 26 , wherein the sensor device performs sensing of the cardiac information signals at the multiple locations stepwise.

29 . The system of claim 1 , further comprising an ablation component for modifying or destroying regions of the heart responsible for a cause of said heart rhythm disorder.

30 . The system of claim 1 , further comprising a plurality of sensors including an ablation component for modifying or destroying regions of the heart responsible for a cause of said heart rhythm disorder.

31 . The system of claim 1 , further comprising software for processing said data.

32 . The system of claim 1 , further comprising determining whether a cause of the heart rhythm disorder is a primary cause of the heart rhythm disorder.

33 . The system of claim 32 , wherein criteria used for determining whether the cause of the heart rhythm disorder is a primary cause are selected from the group consisting of the number of activation trail repetitions, the rate of activation trail repetitions, the number of localized causes, the volume of tissue contained within the activation trail, whether the cause is localized or dispersed, the location of the cause within the heart, and combinations thereof.

34 . The system of claim 32 , wherein the heart rhythm disorders are selected from a group consisting of supraventricular tachycardia, supraventricular bradycardia, ventricular bradycardia, atrial fibrillation, atrial flutter, atrial tachycardia, ventricular tachycardia, ventricular fibrillation or a combination thereof.

35 . The system of claim 1 , further comprising an electronic control system for connecting to one or more of a plurality of sensors.

36 . The system of claim 35 , further comprising an electronic connection switching component for independently switching connections between said plurality of sensors and said electronic control system.

37 . The system of claim 1 , wherein the activation onsets are arranged based on their relative activation onset time.

38 . The system of claim 1 , wherein the processor is further configured to determine at least one approximate co

Assignees

• Univ California

Inventors

• Narayan Sanjiv
• Rappel Wouter-Jan

Classifications

• A61B5/04012

  Human Necessities · mapped topic

• A61B5/02405 Primary

  Determining heart rate variability · CPC title

• A61B5/4836 Primary

  Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence) · CPC title

• A61B5/7405

  using sound · CPC title

• A61B18/1492

  having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence) · CPC title