Methods for detecting biological rhythm disorders

Patent metadata

Field	Value
Publication number	US-9380950-B2
Application number	US-201313964604-A
Country	US
Kind code	B2
Filing date	Aug 12, 2013
Priority date	Oct 9, 2008
Publication date	Jul 5, 2016
Grant date	Jul 5, 2016

Abstract

A method of detecting a cause of a heart rhythm disorder includes collecting data corresponding to activation onset time of each heart activation at multiple locations of the heart and generating an activation trail based on the sequential order of activation onset times. The activation trail is indicative of the cause of the heart rhythm disorder.

First claim

The invention claimed is:

1. A method of detecting a source of a complex heart rhythm disorder, the method comprising:
collecting data associated with heart activation signals sensed by a plurality of sensors disposed at multiple locations in relation to a heart, the data comprising an activation onset time of each heart activation signal at each location such that a plurality of activation onset times at a plurality of locations is collected;
generating an activation trail from the data based on a sequential order of the plurality of activation onset times at the plurality of locations, wherein the activation trail indicates the source of the complex heart rhythm disorder; and
generating a clinical representation that identifies a region of the heart associated with the indicated source.

2. The method of claim 1 , wherein the activation trail comprises a rotational pattern or an outwardly emanating pattern.

3. The method of claim 2 , wherein the rotational pattern or the outwardly emanating pattern is repeating.

4. The method of claim 1 , further comprising visually displaying the activation trail.

5. The method of claim 4 , further comprising visually depicting the activation onset times in relation to a location of each sensor to display the activation trail.

6. The method of claim 1 , further comprising determining an approximate core region in relationship to the activation trail.

7. The method of claim 6 , wherein the activation trail revolves about the approximate core region or the activation trail emanates outwardly from the approximate core region.

8. The method of claim 6 , wherein the approximate core region is a rotor or a focal activation.

9. The method of claim 1 , wherein activation time associated with an activation onset time of a heart activation signal at a location includes the activation onset time and a corresponding offset time.

10. The method of claim 1 , wherein one or more of the multiple locations are within the heart or proximal to the heart.

11. The method of claim 1 , further comprising sensing the heart activation signals at the multiple locations using the plurality of sensors.

12. The method of claim 11 , wherein the sensing of the heart activation signals at the multiple locations is performed concurrently.

13. The method of claim 11 , wherein the sensing of the heart activation signals at the multiple locations is performed stepwise.

14. The method of claim 1 , further comprising augmenting or modifying the activation trail based upon a comparison with a similar activation trail associated with data stored in a database.

15. The method of claim 1 , further comprising:
constructing an electrograph having a voltage-time tracing of heart function at each of the multiple locations; and
inserting a physiological pattern in the electrograph at the activation onset time of each heart activation signal at each location.

16. The method of claim 15 , wherein the physiological pattern comprises a pattern selected from the group consisting of a prior recording from a same patient, a prior recording from a different patient, and a simulated pattern.

17. The method of claim 15 , wherein the physiological pattern is a pattern selected from a group consisting of a unipolar electrogram, a bipolar electrogram, an action potential representation, and a combination thereof.

18. The method of claim 15 , wherein the physiological pattern is adjusted for rate.

19. The method of claim 15 , wherein the physiological pattern is a model of cellular ion function or a model of a pharmacological ligand.

20. The method of claim 15 , wherein the physiological pattern is an action potential representation.

21. The method of claim 1 , further comprising:
analyzing the heart activation signals at one or more of the multiple locations; and
approximating the activation trail based on the analyzing.

22. The method of claim 21 , wherein analyzing comprises analyzing one or more of rate, regularity, amplitude, duration, and location.

23. A method of detecting a source of a complex biological rhythm disorder, the method comprising:
collecting data associated with biological activation signals sensed by a plurality of sensors disposed at multiple locations in relation to an organ, the data comprising an activation onset time of each biological activation signal at each location such that a plurality of activation onset times at a plurality of locations is collected;
generating an activation trail from the data based on a sequential order of the plurality of activation onset times at the plurality of locations, wherein the activation trail indicates the source of the complex biological rhythm disorder; and
generating a clinical representation that identifies a region of the organ associated with the indicated source.

24. The method of claim 23 , wherein the activation trail comprises a rotational pattern or an outwardly emanating pattern.

25. The method of claim 24 , wherein the rotational pattern or the outwardly emanating pattern is repeating.

26. The method of claim 23 , further comprising visually displaying the activation trail.

27. The method of claim 26 , further comprising visually depicting the activation onset times in relation to a location of each sensor to display the activation trail.

28. The method of claim 23 , further comprising sensing the biological activation signals at the multiple locations using the plurality of sensors.

29. The method of claim 23 , further comprising determining an approximate core region in relationship to the activation trail.

30. The method of claim 29 , wherein the activation trail revolves about the approximate core region or the activation trail emanates outwardly from the approximate core region.

31. The method of claim 29 , wherein the approximate core region is a rotor or a focal activation.

Assignees

• Univ California
• Us Dept Of Veterans Affaris Office Of General Counsel

Inventors

• Narayan Sanjiv
• Rappel Wouter-Jan

Classifications

• A61B5/7203

  for noise prevention, reduction or removal · CPC title

• A61B5/726

  using Wavelet transforms · CPC title

• A61B5/04011

  Human Necessities · mapped topic

• A61B5/04012

  Human Necessities · mapped topic

• A61B5/0245

  by using sensing means generating electric signals, {i.e. ECG signals} · CPC title