Poly-benzimidazole with pyrene and anthracene flourophore
US-2016369057-A1 · Dec 22, 2016 · US
Antibody and Recombinant Derivative for the Detection of Trinitrotoluene
US2016200834A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016200834-A1 |
| Application number | US-201614989058-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jan 6, 2016 |
| Priority date | Oct 17, 2012 |
| Publication date | Jul 14, 2016 |
| Grant date | — |
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- Title
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Abstract
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Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
First claim
Opening claim text (preview).
1 . An isolated and purified antibody or functional fragment thereof, comprising: a heavy chain with at least 85% sequence identity to SEQ ID No: 1 and a light chain with at least 85% sequence identity to SEQ ID No: 2, with binding activity to trinitrotoluene. 2 . The isolated and purified antibody or functional fragment thereof of claim 1 , wherein the heavy chain has at least 90% sequence identity to SEQ ID No: 1. 3 . The isolated and purified antibody or functional fragment thereof of claim 1 , wherein the heavy chain has at least 95% sequence identity to SEQ ID No: 1. 4 . The isolated and purified antibody or functional fragment thereof of claim 1 , wherein the heavy chain is SEQ ID No: 1 with one or more mutations selected from the group consisting of: N35S, Q39K, L45S, and W47Y. 5 . The isolated and purified antibody or functional fragment thereof of claim 1 , wherein the light chain has at least 90% sequence identity to SEQ ID No: 2. 6 . The isolated and purified antibody or functional fragment thereof of claim 1 , wherein the light chain has at least 95% sequence identity to SEQ ID No: 2.
Assignees
Inventors
Classifications
Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value · CPC title
Single chain antibody (scFv) · CPC title
Complete light chain, i.e. VL + CL · CPC title
for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites · CPC title
- G01N33/227Primary
Explosives, e.g. combustive properties thereof · CPC title
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Frequently asked questions
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- What does patent US2016200834A1 cover?
- Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
- Who is the assignee on this patent?
- Us Government
- What technology area does this patent fall under?
- Primary CPC classification G01N33/227. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Thu Jul 14 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).