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US-12097501-B2 · Sep 24, 2024 · US
Method for detecting prostatic basal cells
US2016195535A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016195535-A1 |
| Application number | US-201314653562-A |
| Country | US |
| Kind code | A1 |
| Filing date | Dec 18, 2013 |
| Priority date | Dec 20, 2012 |
| Publication date | Jul 7, 2016 |
| Grant date | — |
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Abstract
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The purpose of the present invention is to provide a method for detecting prostatic basal cells by searching for molecules that are expressed specifically in prostatic basal cells and analyzing said molecules. The problem can be solved using a method for detecting prostatic basal cells that is characterized by using immunohistochemical staining to visualize the expression of TRIM29 (Tripartite motif-containing protein 29) protein in prostatic basal cells.
First claim
Opening claim text (preview).
1 . A method for detecting prostatic basal cells, comprising visualizing the expression of tripartite motif-containing protein 29 (TRIM29) protein in basal cells of a prostate by immunohistostaining. 2 . The method for detecting prostatic basal cells according to claim 1 , comprising analyzing the morphology of the glandular tissue structure of the prostate and the visualized expression of tripartite motif-containing protein 29 (TRIM29) protein. 3 . The method for detecting prostatic basal cells according to claim 1 , further comprising visualizing the expression of cytokeratin and/or p63 protein by immunohistostaining. 4 . The method for detecting prostatic basal cells according to claim 3 , comprising analyzing the morphology of the glandular tissue structure of the prostate and the visualized expression of cytokeratin protein and/or the visualized expression of p63 protein. 5 . A method for identifying the presence, decrease, or disappearance of prostatic basal cells, comprising using the method for detecting prostatic basal cells according to claim 1 . 6 . A method for diagnosing prostate cancer, comprising a step of detecting prostatic basal cells in prostate tissue collected from a subject by immunohistostaining using an anti-TRIM29 antibody or an antigen-binding fragment thereof. 7 . The diagnostic method according to claim 6 , wherein the decrease or disappearance of prostatic basal cells as compared to those in normal prostate tissue indicates the presence of prostate cancer. 8 - 10 . (canceled) 11 . An immunohistostaining kit for detecting prostatic basal cells, comprising an anti-TRIM29 antibody or an antigen-binding fragment thereof. 12 . The immunohistostaining kit for detecting prostatic basal cells according to claim 11 , further comprising an anti-cytokeratin antibody or an antigen-binding fragment thereof and/or an anti-p63 antibody or an antigen-binding fragment thereof.
Assignees
Inventors
Classifications
- G01N33/57555Primary
of the prostate · CPC title
Regulators; Modulating activity · CPC title
Keratin; Cytokeratin · CPC title
- G01N33/57434Primary
Physics · mapped topic
against material from animals or humans · CPC title
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- What does patent US2016195535A1 cover?
- The purpose of the present invention is to provide a method for detecting prostatic basal cells by searching for molecules that are expressed specifically in prostatic basal cells and analyzing said molecules. The problem can be solved using a method for detecting prostatic basal cells that is characterized by using immunohistochemical staining to visualize the expression of TRIM29 (Tripartite …
- Who is the assignee on this patent?
- Univ Hokkaido Nat Univ Corp, Lsip Llc
- What technology area does this patent fall under?
- Primary CPC classification G01N33/57555. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Thu Jul 07 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).