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Molecular-based method of cancer diagnosis and prognosis
US9181589B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9181589-B2 |
| Application number | US-201414215574-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 17, 2014 |
| Priority date | Feb 13, 2009 |
| Publication date | Nov 10, 2015 |
| Grant date | Nov 10, 2015 |
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Abstract
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A gene profiling signature for diagnosis and prognosis of cancer patients is disclosed herein. In one embodiment, the gene signature includes 32 or 79 cancer survival factor-associated genes. Thus, provided herein is a method of determining the prognosis of a subject with a tumor by detecting expression of five of more cancer survival factor-associated genes in a tumor sample and comparing expression of the five or more cancer survival factor-associated genes in the tumor sample to a control. In some examples, an increase in expression of ABCF1, CORO1C, DPP3, PREB, UBE3A, and PTDSS1 in a tumor sample compared to a control sample indicates poor prognosis. Further provided are arrays including probes or antibodies specific for a plurality of cancer survival factor-associated genes or proteins.
First claim
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We claim: 1. A method of detecting gene expression in a subject with a tumor, comprising: contacting a tumor sample obtained from the subject with the tumor with probes for each cancer survival factor-associated molecules consisting of all of the cancer survival factor-associated molecules listed in Table 1 and performing real time quantitative polymerase chain reaction analysis; or contacting a tumor sample obtained from the subject with the tumor with a microarray comprising p…
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Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9181589B2 cover?
- A gene profiling signature for diagnosis and prognosis of cancer patients is disclosed herein. In one embodiment, the gene signature includes 32 or 79 cancer survival factor-associated genes. Thus, provided herein is a method of determining the prognosis of a subject with a tumor by detecting expression of five of more cancer survival factor-associated genes in a tumor sample and comparing expr…
- Who is the assignee on this patent?
- Us Health
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/6886. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 10 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).