Atherosclerosis-targeted liposome nanocarrier delivery system and preparation method therefor
US-2024424132-A1 · Dec 26, 2024 · US
US2016184288A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016184288-A1 |
| Application number | US-201514848933-A |
| Country | US |
| Kind code | A1 |
| Filing date | Sep 9, 2015 |
| Priority date | Nov 14, 2008 |
| Publication date | Jun 30, 2016 |
| Grant date | — |
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The invention relates to compounds of formula I: where a, R 1 , and R 3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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What is claimed is: 1 . A pharmaceutical composition comprising a compound of the formula having the chemical name 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine or a pharmaceutically acceptable salt thereof and a pharmaceuticaly acceptable carrier. 2 . The pharmaceutical composition of claim 1 wherein the pharmaceutically acceptable salt is the hydrochloride salt. 3 . A method of treating a pain disorder in a mammal comprising administering to the mammal the pharmaceutical composition of claim 1 . 4 . The method of claim 3 wherein the pain disorder is neuropathic pain, fibromyalgia, chronic low back pain, or osteoarthritis.
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