Matrix film forming device

Patent metadata

Field	Value
Publication number	US-2016172174-A1
Application number	US-201514820622-A
Country	US
Kind code	A1
Filing date	Aug 7, 2015
Priority date	Dec 12, 2014
Publication date	Jun 16, 2016
Grant date	—

Abstract

A matrix film forming device including a first electrode plate including a mounting surface on which a sample plate P is mounted; a second electrode plate arranged facing said mounting surface; a nozzle which sprays a liquid containing a matrix substance by an electrospray process into the space between the first electrode plate and the second electrode plate and is arranged such that the first electrode plate and second electrode plate are not present over the central axis of the spray stream; and an electric field forming device which forms, between the first electrode plate and the second electrode plate, an electric field causes liquid drops containing charged matrix substance contained in the spray stream to move toward said mounting surface.

First claim

What is claimed:

1 . A matrix film forming device for forming a film containing a matrix substance on the surface of a sample plate, comprising:
a) a first electrode plate comprising a mounting surface on which said sample plate is mounted; b) a second electrode plate arranged so as to face said mounting surface; c) a nozzle which sprays a liquid containing a matrix substance by an electrospray process into the space between said first electrode plate and said second electrode plate, and which is arranged such that said first electrode plate and said second electrode plate are not present over the central axis of the spray stream; and d) an electric field forming device which forms an electric field between said first electrode plate and said second electrode plate so as to cause drops of liquid containing said matrix substance, which have been electrically charged and are contained in said spray stream, to move toward said mounting surface.

2 . The matrix film forming device as described in claim 1 , characterized in that said nozzle comprises
e) a capillary having a tubular shape, through which liquid containing said matrix substance flows from the base end side toward a liquid drop spray opening provided on the tip end side; and f) a nebulizer gas ejection channel which is a channel running parallel to said capillary and through which nebulizer gas is ejected in the vicinity of said liquid drop spray opening, the matrix film forming device further comprising g) a voltage application device which applies a direct current voltage to said capillary.

3 . The matrix film forming device as described in claim 1 , characterized in that said nozzle comprises
h) a capillary having a tubular shape, through which liquid containing said matrix substance flows from the base end side toward a liquid drop spray opening provided on the tip end side, the matrix film forming device further comprising i) an opposed electrode arranged at a position opposite the tip end of said nozzle; and j) a voltage application device which applies a direct current voltage between said capillary and said opposed electrode.

4 . The matrix film forming device as described in claim 1 , further comprising
k) an electric field intensity difference forming device which changes the intensity of said electric field over the central axis of said spray stream in accordance with the distance from the tip end of said nozzle.

5 . A matrix film forming device as described in claim 1 , further comprising
l) a liquid drop size adjustment device which adjusts the size of drops of liquid containing said matrix substance which adhere to said sample plate by changing the potential difference between said first electrode plate and said second electrode plate.

6 . A matrix film forming device as described in claim 2 , further comprising
l) a liquid drop size adjustment device which adjusts the size of drops of liquid containing said matrix substance which adhere to said sample plate by changing the potential difference between said first electrode plate and said second electrode plate.

7 . A matrix film forming device as described in claim 3 , further comprising
l) a liquid drop size adjustment device which adjusts the size of drops of liquid containing said matrix substance which adhere to said sample plate by changing the potential difference between said first electrode plate and said second electrode plate.

8 . A matrix film forming device as described in claim 4 , further comprising
1 ) a liquid drop size adjustment device which adjusts the size of drops of liquid containing said matrix substance which adhere to said sample plate by changing the potential difference between said first electrode plate and said second electrode plate.

9 . The matrix film forming device as described in claim 2 , further comprising
k) an electric field intensity difference forming device which changes the intensity of said electric field over the central axis of said spray stream in accordance with the distance from the tip end of said nozzle.

10 . The matrix film forming device as described in claim 3 , further comprising
k) an electric field intensity difference forming device which changes the intensity of said electric field over the central axis of said spray stream in accordance with the distance from the tip end of said nozzle.

11 . A method of forming a matrix film containing a matrix substance on the surface of a sample plate, comprising:
a) mounting a sample plate on a mounting surface of a first electrode plate; b) arranging a second electrode plate to face said mounting surface; c) spraying by a nozzle a liquid containing a matrix substance by an electrospray process into the space between said first electrode plate and said second electrode plate, such that said first electrode plate and said second electrode plate are not present over the central axis of the spray stream; and d) forming an electric field between said first electrode plate and said second electrode plate so as to cause drops of liquid containing said matrix substance, which have been electrically charged and are contained in said spray stream, to move toward said mounting surface.

12 . The method of forming the matrix film as described in claim 11 , further comprising
k) changing the intensity of said electric field over the central axis of said spray stream in accordance with the distance from the tip end of said nozzle.

13 . The method of forming the matrix film as described in claim 11 , further comprising
l) adjusting the size of drops of liquid containing said matrix substance which adhere to said sample plate by changing the potential difference between said first electrode plate and said second electrode plate.

14 . The method of forming the matrix film as described in claim 12 , further comprising
l) adjusting the size of drops of liquid containing said matrix substance which adhere to said sample plate by changing the potential difference between said first electrode plate and said second electrode plate.

Assignees

• Shimadzu Corp

Inventors

• Takahashi Kazuteru

Classifications

• B05B5/005 Primary

  the high voltage supplied to an electrostatic spraying apparatus being adjustable during spraying operation, e.g. for modifying spray width, droplet size · CPC title

• B05D1/04

  involving the use of an electrostatic field {(B05D1/025 and B05D1/14 take precedence)} · CPC title

• H01J49/0418 Primary

  for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates · CPC title

• B05B5/16

  Arrangements for supplying liquids or other fluent material · CPC title

• B05C5/0208

  for applying liquid or other fluent material to separate articles (B05C5/0204 takes precedence) · CPC title