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Composition for monitoring aged tissues, comprising bacteria, and use thereof
US2016129137A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016129137-A1 |
| Application number | US-201514934446-A |
| Country | US |
| Kind code | A1 |
| Filing date | Nov 6, 2015 |
| Priority date | Nov 6, 2014 |
| Publication date | May 12, 2016 |
| Grant date | — |
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Abstract
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A recombinant bacterium for detecting aged tissues and a method of detecting aged tissues in a subject, and a composition for delivering a drug to aged tissues are provided.
First claim
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What is claimed is: 1 . A method of detecting an aged tissue of a subject comprising: administering to the subject a recombinant bacterium comprising a mutation in a relA gene that reduces relA activity as compared to the same bacterium without the mutation, a mutation in a spoT gene that reduces spoT activity as compared to the same bacterium without the mutation, or any combination thereof, and comprising a reporter gene; and detecting position and/or intensity of a signal generated by the reporter gene in the subject, wherein position of the signal, or the position of the greatest intensity of the signal, corresponds to a location of aged tissue in a subject. 2 . The method of claim 1 , wherein the bacterium is Salmonella, Clostridium , or Escherichia genus. 3 . The method of claim 1 , wherein the subject is a mammal. 4 . The method of claim 1 , wherein the recombinant bacterium is administered to the subject intravenously. 5 . The method of claim 1 , wherein the reporter gene encodes a fluorescent protein or a luminescent protein. 6 . The method of claim 1 , wherein the detecting is performed by measuring fluorescence or luminescence.
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the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo · CPC title
- A61K49/0097Primary
Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo · CPC title
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- What does patent US2016129137A1 cover?
- A recombinant bacterium for detecting aged tissues and a method of detecting aged tissues in a subject, and a composition for delivering a drug to aged tissues are provided.
- Who is the assignee on this patent?
- Samsung Electronics Co Ltd, Univ Nat Chonnam Ind Found
- What technology area does this patent fall under?
- Primary CPC classification A61K49/0097. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Thu May 12 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).