Biosensor and wearable device for detecting bioinformation including hybrid electronic sheet

Patent metadata

Field	Value
Publication number	US-2016100778-A1
Application number	US-201514740691-A
Country	US
Kind code	A1
Filing date	Jun 16, 2015
Priority date	Oct 10, 2014
Publication date	Apr 14, 2016
Grant date	—

Abstract

Provided are a biosensor and a wearable device for detecting bioinformation including a hybrid electronic sheet. The biosensor has high electrochemical activity, allows DET-based detection of an analyte in a sample, and has an electrode harmless to the human body to detect an analyte with high sensitivity and selectivity, thereby being usefully applied to a wearable device of detecting bioinformation.

First claim

What is claimed is:

1 . A biosensor comprising:
a substrate; an electronic sheet formed on the substrate; and an analyte-binding material immobilized on the electronic sheet, wherein the electronic sheet comprises a graphitic material and a phage binding to the graphitic material, and the binding of the graphitic material and the phage occurs between the graphitic material and a peptide displayed on a coat protein of the phage or a fragment thereof.

2 . The biosensor of claim 1 , wherein the substrate is an insulating substrate and one or more electrodes are disposed on the substrate.

3 . The biosensor of claim 2 , wherein the one or more electrodes comprise a first electrode and a second electrode.

4 . The biosensor of claim 3 , wherein the electronic sheet is disposed on the first electrode or on a portion thereof.

5 . The biosensor of claim 1 , wherein the substrate is a transparent flexible substrate.

6 . The biosensor of claim 1 , wherein the electronic sheet is patterned on the substrate.

7 . The biosensor of claim 1 , wherein the graphitic material comprises one or more selected from the group consisting of a graphene sheet, a highly ordered pyrolytic graphite (HOPG) sheet, a single-walled carbon nanotube, a double-walled carbon nanotube, a multi-walled carbon nanotube, and fullerene.

8 . The biosensor of claim 1 , wherein the graphitic material comprises a graphene sheet and a single-walled carbon nanotube.

9 . The biosensor of claim 1 , wherein the peptide comprises one or more selected from the group consisting of amino acid sequences of SEQ ID NOS. 1 to 8.

10 . The biosensor of claim 1 , wherein the phage is M13 phage, F1 phage, Fd phage, If1 phage, Ike phage, Zj/Z phage, Ff phage, Xf phage, Pf1 phage or Pf3 phage.

11 . The biosensor of claim 1 , wherein the analyte-binding material is oxidase, peroxidase, reductase, catalase or dehydrogenase.

12 . The biosensor of claim 1 , further comprising a protection layer formed on the immobilized analyte-binding material.

13 . The biosensor of claim 1 , wherein the electronic sheet has a surface contacting the analyte-binding material, and a surface of the electronic sheet has a positive or negative charge that is opposite to a charge of the analyte-binding material.

14 . The biosensor of claim 1 , wherein the biosensor comprises a plurality of repeating units, each repeating unit comprising the electronic sheet and the analyte-binding material.

15 . The biosensor of claim 1 , further comprising a test cell for accommodating a sample, the electronic sheet, and the analyte-binding material, wherein the test cell has a channel having an inlet for accepting the sample and an outlet for discharging the sample.

16 . A wearable device for detecting bioinformation, comprising the biosensor of claim 1 .

17 . The wearable device of claim 15 , wherein the wearable device is a contact lens.

Assignees

• Korea Inst Sci & Tech

Inventors

• Yi Hyunjung
• Lee Ki Young
• Lee Seungwoo
• Jang Cha Un
• Chang Joonyeon

Classifications

• A61B5/681

  Wristwatch-type devices · CPC title

• A61B5/6821

  Eye · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/6833

  Adhesive patches · CPC title

• A61B5/1486 Primary

  using enzyme electrodes, e.g. with immobilised oxidase · CPC title