Method for producing a protein hydrolysate
US-10619177-B2 · Apr 14, 2020 · US
Serine protease variant
US12570967B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12570967-B2 |
| Application number | US-202217997455-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 11, 2022 |
| Priority date | Mar 12, 2021 |
| Publication date | Mar 10, 2026 |
| Grant date | Mar 10, 2026 |
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- Title
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Abstract
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The present disclosure relates to a novel serine protease variant.
First claim
Opening claim text (preview).
The invention claimed is: 1 . A serine protease variant having at least 75% sequence identity with SEQ ID NO: 54 and comprising tyrosine (Y) at a position corresponding to position 12 of SEQ ID NO: 54. 2 . The serine protease variant according to claim 1 , wherein the variant further comprises a substitution of an amino acid corresponding to position 116 of SEQ ID NO: 54. 3 . The serine protease variant according to claim 1 having at least 75% sequence identity to SEQ ID NO: 70, SEQ ID NO: 71, or SEQ ID NO: 72. 4 . The serine protease variant according to claim 2 , wherein the amino acid corresponding to position 116 is substituted with a hydrophilic amino acid, a nonpolar amino acid, or an acidic amino acid. 5 . The serine protease variant according to claim 2 , wherein the amino acid corresponding to position 116 is substituted with aspartate (D), serine(S), threonine (T), or glycine (G). 6 . A composition comprising the serine protease variant according to claim 1 . 7 . A polynucleotide encoding a serine protease variant that comprises: (a) the amino acid sequence of SEQ ID NO: 52 except that the amino acid at position 12 of SEQ ID NO: 52 is substituted with tyrosine (Y), (b) the amino acid sequence of SEQ ID NO: 53 except that the amino acid at position 12 of SEQ ID NO: 53 is substituted with tyrosine (Y), or (c) the amino acid sequence of SEQ ID NO: 54 except that the amino acid at position 12 of SEQ ID NO: 54 is substituted with tyrosine (Y). 8 . A vector comprising the polynucleotide according to claim 7 . 9 . A host cell comprising the serine protease variant according to claim 1 . 10 . A composition comprising a microorganism expressing the serine protease variant according to claim 1 . 11 . The serine protease variant according to claim 3 , wherein the serine protease variant comprises tyrosine (Y) at a position corresponding to position 203 of SEQ ID NO: 70. 12 . A composition comprising the serine protease variant according to claim 3 . 13 . A polynucleotide encoding a serine protease variant that comprises: (a) the amino acid sequence of SEQ ID NO: 70 except that the amino acid at position 203 of SEQ ID NO: 70 is substituted with tyrosine (Y), (b) the amino acid sequence of SEQ ID NO: 71 except that the amino acid at position 201 of SEQ ID NO: 71 is substituted with tyrosine (Y), or (c) the amino acid sequence of SEQ ID NO: 72 except that the amino acid at position 201 of SEQ ID NO: 72 is substituted with tyrosine (Y). 14 . A vector comprising the polynucleotide according to claim 13 . 15 . A host cell comprising the serine protease variant according to claim 8 . 16 . A composition comprising a microorganism expressing the serine protease variant according to claim 3 . 17 . A host cell comprising the polynucleotide according to claim 7 ; or a vector comprising the polynucleotide. 18 . A host cell comprising the polynucleotide according to claim 13 ; or a vector comprising the polynucleotide.
Assignees
Inventors
Classifications
Serine endopeptidases (3.4.21) · CPC title
Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions (A23K10/12 takes precedence) · CPC title
Pretreatment of feeding-stuffs with enzymes · CPC title
for Bacillus · CPC title
Genes encoding for enzymes or proenzymes · CPC title
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Frequently asked questions
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- What does patent US12570967B2 cover?
- The present disclosure relates to a novel serine protease variant.
- Who is the assignee on this patent?
- Cj Cheiljedang Corp
- What technology area does this patent fall under?
- Primary CPC classification C12N9/52. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).