Treatment fluid devices methods and systems

Patent metadata

Field	Value
Publication number	US-12564664-B2
Application number	US-202318200666-A
Country	US
Kind code	B2
Filing date	May 23, 2023
Priority date	Oct 30, 2015
Publication date	Mar 3, 2026
Grant date	Mar 3, 2026

Abstract

A conductivity measurement device includes first and second conductivity measurement flow channels positioned in a fluid circuit and fluidly linked for fluid flow between the first and second conductivity measurement flow channels. A controller having a current source connected to the first and second conductivity channels applies alternating voltages at frequencies that are different, each being respective to one of the first and second conductivity cells.

First claim

What is claimed is:

1 . A method of providing dialysate, comprising:
filling first and second containers with first and second concentrate components for a sodium lactate-based dialysate solution, the first and second concentrate components, when combined in a predefined ratio and diluted with water, forming a functional dialysate suitable for a dialysis treatment; the first and second concentrate components being constituted such that sodium lactate is at least partly separated from sodium chloride and glucose to an extent such that no precipitation occurs in either container after storage for a period of at least two days while a level of concentration of the first and second concentrate components are such that if the first and second concentrate components are combined and stored for the period of at least two days, a precipitation would occur in a combination of the first and second concentrate components.

2 . The method of claim 1 , further comprising providing the first and second containers to a treatment site and combining and diluting the first and second concentrate components to form a dialysate for treatment.

3 . The method of claim 1 , further comprising, sterilizing internal surfaces of said first and second containers prior to said filling.

4 . The method of claim 3 , further comprising, sterile filtering said first and second concentrate components prior to said filling.

5 . The method of claim 1 , wherein the first concentrate component includes sodium chloride and glucose and the second concentrate component includes sodium lactate.

6 . The method of claim 5 , wherein the sodium lactate has a concentration of at least 35 mEq.

7 . The method of claim 6 , wherein the second concentrate component includes no glucose.

8 . The method of claim 7 , wherein the second concentrate component includes no sodium chloride.

9 . The method of claim 1 , wherein the first and second concentrate components contain glucose and the second concentrate contains no sodium chloride.

10 . The method of claim 9 , wherein the second concentrate component contains less glucose than the first concentrate component.

11 . The method of claim 1 , wherein the first and second concentrate components both contain sodium lactate, the second concentrate component containing a higher concentration of sodium lactate than the first concentrate component.

12 . A dialysate concentrate article of manufacture, comprising:
first and second containers containing first and second concentrate components for a sodium lactate-based dialysate solution, the first and second concentrate components, when combined in a predefined ratio and diluted with water, forming a functional dialysate suitable for a dialysis treatment; the first and second concentrate components being constituted such that sodium lactate is at least partly separated from sodium chloride and glucose to an extent such that no precipitation occurs in either container after storage for a period of at least two days while a level of concentration of the first and second concentrate components are such that if the first and second concentrate components are combined and stored for the period of at least two days, a precipitation would occur in a combination of the first and second concentrate components.

13 . The article of manufacture of claim 12 , wherein the first and second containers are suitable for storage and transport to a treatment site and are constructed for connection to a predefined system for diluting the first and second concentrate components to form a dialysate for treatment.

14 . The article of manufacture of claim 12 , wherein internal surfaces of said first and second containers are sterile.

15 . The article of manufacture of claim 12 , wherein the first concentrate component includes sodium chloride and glucose and the second concentrate component includes sodium lactate.

16 . The article of manufacture of claim 12 , wherein the first concentrate component includes sodium chloride and glucose and the second concentrate component includes sodium lactate at a concentration of at least 35 mEq.

17 . The article of manufacture of claim 16 , wherein the second concentrate component includes no sodium chloride.

18 . The article of manufacture of claim 16 , wherein the second concentrate component includes no glucose.

19 . The article of manufacture of claim 12 , wherein the second concentrate component contains less glucose than the first concentrate component.

20 . The article of manufacture of claim 12 , wherein the first and second concentrate components both contain sodium lactate, the second concentrate component containing a higher concentration of sodium lactate than the first concentrate component.

Assignees

• Nxstage Medical Inc

Inventors

• Soto Orlando
• Rausa Joseph
• Brugger James M
• Schnell William J
• Friederichs Goetz
• Burbank Jeffrey H
• Turk Jr Joseph E
• Newell Scott W
• Wozniak Amanda

Classifications

• A61M1/1561

  at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil · CPC title

• A61M1/1562

  Details of incorporated reservoirs · CPC title

• A61M1/1565

  Details of valves · CPC title

• A61M1/155

  with treatment-fluid pumping means or components thereof · CPC title

• A61M1/154

  with sensing means or components thereof · CPC title