Medicament preparation and treatment devices, methods, and systems

Patent metadata

Field	Value
Publication number	US-10478544-B2
Application number	US-201515514230-A
Country	US
Kind code	B2
Filing date	Sep 25, 2015
Priority date	Sep 25, 2014
Publication date	Nov 19, 2019
Grant date	Nov 19, 2019

Abstract

A medicament preparation system, according to an embodiment, includes a water purification module and a medicament proportioning module. The system is configured to allow convenient and safe use in a home environment or a critical care environment as well as others affording safety, reliability, and a compact form factor.

First claim

The invention claimed is:

1. A fluid circuit for preparation of a medicament for renal replacement therapy, comprising:
a concentrate container containing acid concentrate connected for flow communication, through a first pumping tube segment, to a medicament supply line that has been capped and sterile-sealed at an outlet end thereof;
a bicarbonate cartridge containing dry bicarbonate buffer compound, the bicarbonate cartridge being of a type that admits water in a cartridge inlet thereby forming a saturated bicarbonate solution which is received at a cartridge outlet, the cartridge outlet being connected for flow communication, through a second pumping tube segment, to the medicament supply line; and
a water inlet line, capped and sterile-sealed, connected for flow communication, through a third pumping tube segment, to the medicament supply line and connected for flow communication to the bicarbonate cartridge inlet;
the first, second, and third pumping tube segments being supported by a circuit cartridge which orients, aligns, and exposes for access the first, second, and third pumping tube segments with respective actuators of a predefined medicament preparation device;
the circuit cartridge containing a first concentration sensor station positioned in said medicament supply line downstream of a first junction where the first pumping tube segment connects to the medicament supply line;
the circuit cartridge containing a second concentration sensor station positioned in said medicament supply line downstream of both said first junction and a second junction where the second pumping tube segment connects to the medicament supply line, wherein
each of said concentration sensor stations includes a liquid conductivity sensor and a temperature sensor portion,
the temperature sensor portion includes a flow chamber with a flat surface to permit a temperature sensor to be placed against said flat surface of a predefined sensor of the predefined medicament preparation device, and
the entire fluid circuit is sterile.

2. The circuit of claim 1 , wherein the circuit cartridge includes a fluid accumulator fluidly coupled between the water inlet line and the medicament supply line outlet end that includes a pressure-regulating urging element that biases a flexible wall of the accumulator such that transient changes of fluid pressure therein cause expansion of the volume of the accumulator.

3. The circuit of claim 1 , wherein the fluid circuit is packaged with a box such that the circuit cartridge can be detached or removed from the box while leaving the concentrate container and bicarbonate cartridge intact therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

4. The circuit of claim 1 , wherein the fluid circuit is packaged within a box such that the circuit cartridge can be removed from the box while leaving the concentrate container and bicarbonate cartridge intact therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

5. The circuit of claim 1 , wherein the fluid circuit is attached to a box in such a way that the circuit cartridge can be detached from the box while leaving the concentrate container and bicarbonate cartridge intact therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

6. The circuit of claim 3 , wherein the box is principally of cardboard.

7. The circuit of claim 1 , wherein each of said concentration stations includes, connected in series, two independent conductivity sensors and two independent temperature sensor portions.

8. The circuit of claim 2 , wherein the medicament supply line includes a waste outlet branch that is in direct fluid communication with the accumulator, the waste outlet branch being capped and sterile-sealed, the medicament supply line outlet line and waste outlet branch having pinching portions supported in an open section of said circuit cartridge to permit access by pinching actuators.

9. A fluid circuit for preparation of a medicament for renal replacement therapy, comprising:
a first container containing acid concentrate connected for flow communication, through a first pumping tube segment, to a medicament supply line that has been capped and sterile-sealed at an outlet end thereof;
a second container containing a buffer concentrate connected for flow communication, through a second pumping tube segment, to the medicament supply line; and
a water inlet line, capped and sterile-sealed, connected for flow communication, through a third pumping tube segment, to the medicament supply line;
the first, second, and third pumping tube segments being supported by a circuit cartridge which orients, aligns, and exposes for access the first, second, and third pumping tube segments with respective actuators of a predefined medicament preparation device;
the circuit cartridge containing a first concentration sensor station positioned in said medicament supply line downstream of a first junction where the first pumping tube segment connects to the medicament supply line;
the circuit cartridge containing a second concentration sensor station positioned in said medicament supply line downstream of both said first junction and a second junction where the second pumping tube segment connects to the medicament supply line, wherein
each of said concentration sensor stations includes a liquid conductivity sensor and a temperature sensor portion,
the temperature sensor portion includes a flow chamber with a flat surface to permit a temperature sensor to be placed against said flat surface of a predefined sensor of the predefined medicament preparation device, and
the entire fluid circuit is sterile.

10. The circuit of claim 9 , wherein the circuit cartridge includes a fluid accumulator fluidly coupled between the water inlet line and the medicament supply line outlet end that includes a pressure-regulating urging element that biases a flexible wall of the accumulator such that transient changes of fluid pressure therein cause expansion of the volume of the accumulator.

11. The circuit of claim 9 , wherein the fluid circuit is packaged with a box such that the circuit cartridge can be detached or removed from the box while leaving the first and second containers therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

12. The circuit of claim 9 , wherein the fluid circuit is packaged within a box such that the circuit cartridge can be removed from the box while leaving the first and second containers therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

13. The circuit of claim 9 , wherein the fluid circuit is attached to a box in such a way that the circuit cartridge can be detached from the box while leaving the first and second containers therein with lengths of connecting lines between the circuit cartridge and the box, thereby permitting the circuit cartridge to be installed in a position remote form a position where the box is installed.

14. The circuit of claim 11 ,

Assignees

• Nxstage Medical Inc

Inventors

• Friederichs Goetz
• Weigel William
• Treu Dennis M
• Burbank Jeffrey H
• Brugger James M
• Wheeler Keith J
• Newell Scott W

Classifications

• C02F2303/04

  Disinfection · CPC title

• C02F9/00

  Multistage treatment of water, waste water or sewage · CPC title

• A61M2205/502

  User interfaces, e.g. screens or keyboards · CPC title

• C02F1/44

  by dialysis, osmosis or reverse osmosis {(general membrane separation processes B01D61/00, membrane modules B01D63/00, electrodialysis C02F1/4693, combination of membrane modules and bioreactors C02F3/1268)} · CPC title

• C02F2001/427

  using mixed beds · CPC title