Bioerodible wraps and uses therefor

Patent metadata

Field	Value
Publication number	US-12544213-B2
Application number	US-202318505610-A
Country	US
Kind code	B2
Filing date	Nov 9, 2023
Priority date	Oct 28, 2009
Publication date	Feb 10, 2026
Grant date	Feb 10, 2026

Abstract

A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.

First claim

We claim:

1 . A graft device comprising:
a tubular vascular tissue having a wall defining a lumen, the lumen extending from a first end of the tubular tissue to a second end of the tubular tissue, the wall having an exterior surface; a fiber matrix deposition comprising a polymer, the fiber matrix deposition surrounding the exterior surface of the tubular tissue and having a first surface adjacent the exterior surface of the tubular tissue and a second surface opposite the first surface and spaced from the exterior surface of the tubular tissue; and a scaffold that at least partially surrounds the second surface of the fiber matrix deposition and is at least partially intertwined with the fiber matrix deposition.

2 . The graft device of claim 1 , wherein the fiber matrix deposition surrounds the exterior surface of the tubular tissue from the first end to the second end of the tubular tissue.

3 . The graft device of claim 2 , wherein the scaffold at least partially surrounds the second surface of the fiber matrix deposition from the first end to the second end of the tubular tissue.

4 . The graft device of claim 1 , wherein the exterior surface of the tubular tissue defines a circumference, the fiber matrix deposition surrounding the circumference of the tubular tissue.

5 . The graft device of claim 1 , wherein the scaffold has at least one of a mesh structure, a coil structure, a braided structure, or a knitted structure.

6 . The graft device of claim 1 , wherein the scaffold is flexible.

7 . The graft device of claim 1 , wherein the scaffold is anisotropic.

8 . The graft device of claim 1 , wherein the scaffold and the fiber matrix deposition are bonded.

9 . The graft device of claim 1 , wherein the fiber matrix deposition and the scaffold comprise a two-layer or laminate structure.

10 . The graft device of claim 1 , wherein the scaffold comprises a first material selected from the group consisting of nitinol, stainless steel, a plastic, a polymer, and combinations thereof.

11 . The graft device of claim 1 , wherein the fiber matrix deposition comprises at least one of a poly(ester urethane) urea, a polylactide, a poly(lactide-co-glycolide), a poly(L-lactide-co-caprolactone), a polyglycolic acid, a poly(dl-lactide-co-glycolide), a poly(l-lactide-co-dl-lactide), a polycaprolactone, a polycarbonate, a polyglyconate, a poly(glycolide-co-trimethylene carbonate), a poly(glycolide-co-trimethylene carbonate-co-dioxanone), a polyurethane, a poly(ester urethane) urea, a poly(ester urethane) urea elastomer, a polyalkanoate, a polyhydroxybutyrate, a polyhydroxyvalerate, a polydioxanone, a polygalactin, a natural polymer, chitosan, collagen, elastin, alginate, cellulose, hyaluronic acid, and/or gelatin.

12 . The graft device of claim 1 , wherein the fiber matrix deposition comprises a poly(ester urethane) urea with from about 25% wt. to about 75% wt. collagen.

13 . The graft device of claim 12 , wherein the fiber matrix deposition further comprises elastin.

14 . A graft device comprising:
a first layer comprising a tubular vascular tissue having a wall defining a lumen, the lumen extending from a first end of the tubular tissue to a second end of the tubular tissue, the wall having an exterior surface; and a second layer comprising a fiber matrix deposition comprising a polymer and a scaffold, the scaffold at least partially intertwined with the fiber matrix deposition, the second layer surrounding the exterior surface of the tubular tissue.

15 . The graft device of claim 14 , wherein the scaffold comprises a first material selected from the group consisting of nitinol, stainless steel, a plastic, a polymer, and combinations thereof.

16 . The graft device of claim 14 , wherein the fiber matrix deposition comprises at least one of a poly(ester urethane) urea, a polylactide, a poly(lactide-co-glycolide), a poly(L-lactide-co-caprolactone), a polyglycolic acid, a poly(dl-lactide-co-glycolide), a poly(l-lactide-co-dl-lactide), a polycaprolactone, a polycarbonate, a polyglyconate, a poly(glycolide-co-trimethylene carbonate), a poly(glycolide-co-trimethylene carbonate-co-dioxanone), a polyurethane, a poly(ester urethane) urea, a poly(ester urethane) urea elastomer, a polyalkanoate, a polyhydroxybutyrate, a polyhydroxyvalerate, a polydioxanone, a polygalactin, a natural polymer, chitosan, collagen, elastin, alginate, cellulose, hyaluronic acid, and/or gelatin.

17 . The graft device of claim 14 , wherein the fiber matrix deposition comprises a poly(ester urethane) urea with from about 25% wt. to about 75% wt. collagen.

18 . The graft device of claim 17 , wherein the fiber matrix deposition further comprises elastin.

19 . The graft device of claim 14 , wherein the second layer comprises a single layer or composite structure.

Assignees

• Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education

Inventors

• El-Kurdi Mohammed S
• Wagner William R
• Vorp David A
• Stankus John J
• Soletti Lorenzo
• Mcgrath Jonathan
• Hong Yi
• Flaherty J Christopher

Classifications

• A61F2002/072

  Encapsulated stents, e.g. wire or whole stent embedded in lining · CPC title

• A61F2/062

  Apparatus for the production of blood vessels made from natural tissue or with layers of living cells · CPC title

• A61F2/04

  Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95) · CPC title

• A61F2/06 Primary

  Blood vessels · CPC title