Bioerodible wraps and uses therefor

Patent metadata

Field	Value
Publication number	US-9237945-B2
Application number	US-2243008-A
Country	US
Kind code	B2
Filing date	Jan 30, 2008
Priority date	Jan 30, 2007
Publication date	Jan 19, 2016
Grant date	Jan 19, 2016

Abstract

A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.

First claim

We claim:

1. A tubular tissue graft device comprising:
a living tubular tissue structure having a wall surrounding a lumen, the wall having an outer surface comprising a series of non-circular cross-sections varying at least in part over a portion of the length of the living tubular tissue structure; and
an electrospun deposition coating formed of one or more bioerodible polymer fibers oriented circumferentially about the outer surface and along a portion of the length of the living tubular tissue structure, wherein the coating forms a restrictive fiber matrix with inherent anisotropy on the series of non-circular cross-sections that compose the outer surface of the living tubular tissue structure.

2. The device of claim 1 , wherein the living tubular tissue structure is venous.

3. The device of claim 2 , wherein the venous living tubular tissue structure is obtained from a saphenous vein.

4. The device of claim 1 , wherein the one or more bioerodible polymer fibers comprise a polymer comprising ester and urethane linkages.

5. The device of claim 4 , wherein the polymer comprising ester and urethane linkages comprises a poly(ester urethane)urea.

6. The device of claim 1 , wherein the living tubular tissue structure is obtained from an artery, urethra, intestine, esophagus, ureter, trachea, bronchi, and fallopian tube, or a combination thereof.

7. The device of claim 1 , wherein the one or more bioerodible polymer fibers comprise a polymer derived from an alpha-hydroxy acid, a polylactide, a poly(lactide-co-glycolide), a poly(L-lactide-co-caprolactone), a polyglycolic acid, a poly(dl-lactide-co-glycolide), a poly(1-lactide-co-dl-lactide), a polymer comprising a lactone monomer, a polycaprolactone, a polymer comprising carbonate linkages, a polycarbonate, a polyglyconate, a poly(glycolide-co-trimethylene carbonate), a poly(glycolide-co-trimethylene carbonate-co-dioxanone), a polymer comprising urethane linkages, a polyurethane, a poly(ester urethane) urea, a poly(ester urethane) urea elastomer, a polymer comprising ester linkages, a polyalkanoate, a polyhydroxybutyrate, a polyhydroxyvalerate, a polydioxanone, a polygalactin, a natural polymer, chitosan, collagen, elastin, alginate, cellulose, hyaluronic acid, gelatin, or a combination thereof.

8. The device of claim 1 , wherein the one or more bioerodible polymer fibers comprise one or more polymers derived from an alpha-hydroxy acid.

9. The device of claim 8 , wherein the one or more polymers derived from an alpha-hydroxy acid comprise a polylactide, a poly(lactide-co-glycolide), a poly(L-lactide-co-caprolactone), a polyglycolic acid, a poly(dl-lactide-co-glycolide), a poly(1-lactide-co-dl-lactide), or a combination thereof.

10. The device of claim 1 , wherein the one or more bioerodible polymer fibers comprise one or more polymers comprising a lactone monomer.

11. The device of claim 10 , wherein the one or more polymers comprising a lactone monomer comprise polycaprolactone.

12. The device of claim 1 , wherein the one or more bioerodible polymer fibers comprise one or more polymers comprising carbonate linkages.

13. The device of claim 12 , wherein the one or more polymers comprising carbonate linkages comprise polycarbonate, polyglyconate, poly(glycolide-co-trimethylene carbonate), poly(glycolide-co-trimethylene carbonate-co-dioxanone), or a combination thereof.

14. The device of claim 1 , wherein the one or more bioerodible polymer fibers comprise one or more polymers comprising urethane linkages.

15. The device of claim 14 , wherein the one or more polymers comprising urethane linkages comprise a polyurethane, a poly(ester urethane) urea elastomer, or a combination thereof.

16. The device of claim 15 , wherein the one or more polymers comprising urethane linkages comprise the poly(ester urethane) urea elastomer.

17. The device of claim 16 , wherein the one or more bioerodible polymer fibers further comprise collagen.

18. The device of claim 17 , wherein the restrictive fiber matrix comprises from about 25% wt. to about 75% wt. collagen.

19. The device of claim 17 , wherein one or more bioerodible polymer fibers further comprise elastin.

20. The device of claim 19 , wherein the restrictive fiber matrix comprises from about 25% wt. to about 75% wt. of a mixture of collagen and elastin.

21. The device of claim 19 , wherein the elastin and the collagen are present in the restrictive fiber matrix in approximately equal amounts.

22. The device of claim 1 , wherein the one or more bioerodible polymer fibers comprise ester linkages.

23. The device of claim 22 , wherein the one or more bioerodible polymer fibers comprising ester linkages comprise a polyalkanoate.

24. The device of claim 23 , wherein the polyalkanoate comprises a polyhydroxybutyrate, polyhydroxyvalerate, and polydioxanone, or a combination thereof.

25. The device of claim 22 , wherein the one or more bioerodible polymer fibers comprising ester linkages comprise a polygalactin.

26. The device of claim 1 , wherein the one or more bioerodible polymer fibers comprise one or more natural polymers.

27. The device of claim 26 , wherein the one or more natural polymers comprise chitosan, collagen, elastin, alginate, cellulose, polyalkanoates, hyaluronic acid, gelatin, or a combination thereof.

28. The device of claim 1 , wherein the one or more bioerodible polymer fibers comprise collagen.

29. The device of claim 28 , wherein the one or more bioerodible polymer fibers further comprise elastin.

30. The device of claim 28 , wherein the restrictive fiber matrix bioerodes in situ over a time period ranging from 12 hours to two weeks.

31. The device of claim 1 , further comprising one or more cells, active agents, or a combination thereof, associated with the restrictive fiber matrix.

32. The device of claim 31 , comprising the one or more cells that are stem cells, progenitor (precursor) cells, smooth muscle cells, skeletal myoblasts, myocardial cells, endothelial cells, endothelial progenitor cells, bone-marrow derived mesenchymal cells, genetically modified cells, or a combination thereof.

33. The device of claim 31 , comprising the one or more active agents that comprise a growth factor.

34. The device of claim 33 , wherein the growth factor comprises basic fibroblast growth factor (bFGF), acidic fibroblast growth factor (aFGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), insulin-like growth factors (IGF), transforming growth factor-beta pleiotrophin protein, midkine protein, IGF-1, or a combination thereof.

35. The device of claim 31 further comprising the one or more active agents that comprise a drug.

36. The device of claim 35 , wherein the drug comprises a non-steroidal anti-inflammatory drug, an antibiotic, an anticlotting factor, an immunosuppressant, a glucocorticoid, a drug acting on an immunophilin, an interferon, a TNF binding proteins, a taxane, a statin, and a nitric oxide donor or precursor, or a combination thereof.

37. The device of claim 35 , wherein the drug comprises an NSAID, salicylic acid, indomethacin, sodium indomethacin trihydrate, salicylamide, naproxen, colchicine, fenoprofen, sulindac, diflunisal, diclofenac, indoprofen sodium

Assignees

• El-Kurdl Mohammed S
• Hong Yi
• Soletti Lorenzo
• Stankus John J
• Vorp David A
• Wagner William R
• Univ Pittsburgh—Of The Commonwealth System Of Higher Education

Inventors

• El-Kurdl Mohammed S
• Hong Yi
• Soletti Lorenzo
• Stankus John J
• Vorp David A
• Wagner William R

Classifications

• A61L27/3625

  Vascular tissue, e.g. heart valves · CPC title

• D10B2331/10

  polyurethanes · CPC title

• A61L2300/604

  Biodegradation · CPC title

• A61L2300/414

  Growth factors · CPC title

• A61L27/34 Primary

  Macromolecular materials · CPC title