Method of treatment of obesity

Patent metadata

Field	Value
Publication number	US-12533333-B2
Application number	US-202418677055-A
Country	US
Kind code	B2
Filing date	May 29, 2024
Priority date	Mar 15, 2016
Publication date	Jan 27, 2026
Grant date	Jan 27, 2026

Abstract

The present invention provides compositions and pharmaceutical compositions of GPR84 agonists and GPR120 agonists for us in the treatment of obesity and overweight. The invention provides methods of treatment accordingly as well as a kit for use in the treatment of obesity and overweight.

First claim

The invention claimed is:

1 . A method of treating obesity and overweight comprising administering to a subject in need thereof a delayed release formulation of a composition comprising a GPR84 agonist and a GPR120 agonist;
wherein the GPR84 agonist is:
a) lauric acid (C12:0), or an ester thereof; and
wherein the GPR120 agonist is:
a) α-linolenic acid (ALA), or an ester thereof;

wherein the delayed release formulation is for release in the distal small intestine and large intestine.

2 . The method of claim 1 , wherein the composition further comprises a second GPR84 agonist.

3 . The method of claim 2 , wherein the second GPR84 agonist is capric acid.

4 . The method of claim 2 , wherein the α-linolenic acid is from a natural source.

5 . The method of claim 4 , wherein the natural source is a plant seed oil.

6 . The method of claim 1 , wherein the α-linolenic acid is from a natural source.

7 . The method of claim 6 , wherein the natural source of α-linolenic acid is a plant seed oil.

8 . The method of claim 7 , wherein the plant seed oil is linseed oil.

9 . The method of claim 1 , wherein the composition further comprises an amino acid.

10 . The method of claim 1 , wherein the formulation is a delayed release capsule.

11 . The method of claim 5 , wherein the plant seed oil is linseed oil.

Assignees

• Univ London Queen Mary

Inventors

• Peiris Madusha
• Blackshaw Ashley

Classifications

• A61K45/05

  Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• A61K45/00

  Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00 · CPC title

• A61K36/55

  Linaceae (Flax family), e.g. Linum · CPC title

• A61K31/192

  having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid  {(cannabinoids A61K31/658)} · CPC title