Method for preparing oil-dispersible carotenoid preparation

Patent metadata

Field	Value
Publication number	US-2016374375-A1
Application number	US-201414902553-A
Country	US
Kind code	A1
Filing date	Jun 3, 2014
Priority date	Jul 9, 2013
Publication date	Dec 29, 2016
Grant date	—

Abstract

Disclosed in the present invention is a method for preparing an oil-dispersible carotenoid preparation, comprising (by weight parts): mixing 100 parts of carotenoid microcapsule, 100-400 parts of vegetable oil and 0.1-1 part of oil-soluble antioxidant; and grinding the mixture in a colloid mill in a nitro—gen atmosphere and at 10-30° C. to obtain a uniform oil-dispersible carotenoid preparation, wherein the preparation contains 2%-14% carotenoid with an average particle size of up to 0.1-1 μm, and 100 parts of carotenoid microcapsule contains 10.5-35.8 parts carotenoid, 0.1-1 part of water-soluble antioxidant, and the remainder is a water-soluble colloid. The advantages of the present invention lie in that the oil-dispersible form has a high stability as the surface of the carotenoid particles is still protected with a dense water-soluble colloid, and that an oil-dispersible carotenoid preparation containing carotenoid with a content of up to 2%-14% and an average particle size of only 0.1-1 μm can be prepared.

First claim

1 . A method for preparing an oil-dispersible carotenoid preparation, comprising (by weight parts):
mixing 100 parts of carotenoid microcapsule, 100˜400 parts of vegetable oil and 0.1˜1 part of antioxidant B, and grinding the mixture in a colloid mill in a nitrogen atmosphere at 10˜30° C. to obtain a uniform oil-dispersible carotenoid preparation, wherein average particle size of the carotenoid is up to 0.1˜1 μm; wherein the 100 parts of carotenoid microcapsule contains 10.5˜35.8 parts carotenoid, 0.1˜1 part of antioxidant A and the remaining is a water-soluble colloid; the antioxidant A is vitamin C, vitamin C sodium, iso-vitamin C or iso-vitamin C sodium; the antioxidant B is tocopherol, ethoxyquin, BHT (2,6-di-tert-butyl-4-methylphenol) or TBHQ (tert-butylhydroquinone).

2 . The method for preparing the oil-dispersible carotenoid preparation according to claim 1 , wherein the carotenoid is beta-carotene, astaxanthin, lycopene, canthaxanthin or lutein.

3 . The method for preparing the oil-dispersible carotenoid preparation according to claim 1 , wherein the water-soluble colloid is gelatin, octenyl succinic starch ester or Arabic gum.

4 . The method for preparing the oil-dispersible carotenoid preparation according to claim 1 , wherein the vegetable oil is soybean oil, corn oil, sunflower seed oil, peanut oil or salad oil.

5 . An oil-dispersible carotenoid preparation prepared with the method for preparing the oil-dispersible carotenoid preparation according to claim 1 .

Assignees

• Zhejiang New Weipu Additive Co Ltd
• Univ Zhejiang
• Zhejiang Nhu Co Ltd

Inventors

• Qiu Dan
• Shi Lifang
• Li Jiandong
• Chen Zhirong
• Zhou Jiachao

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K8/345

  containing more than one hydroxy group · CPC title

• A61K2800/10

  General cosmetic use · CPC title

• A61K31/015 Primary

  carbocyclic · CPC title

• A23L5/44 Primary

  using carotenoids or xanthophylls · CPC title