Light irradiation apparatus

Patent metadata

Field	Value
Publication number	US-12529644-B2
Application number	US-202418732356-A
Country	US
Kind code	B2
Filing date	Jun 3, 2024
Priority date	Jul 25, 2019
Publication date	Jan 20, 2026
Grant date	Jan 20, 2026

Abstract

A light irradiation device including an injection unit to inject a sample, and a light source to apply light to the sample to identify an abnormal cell in the sample, the light source including a substrate and a light emitter including a light emitting diode, in which the light emitted is to cut a genetic material in the sample into sections of different sizes, and to deform the genetic material to different degrees, such that a determination of an abnormality of the sample is based on the degree of deformation, and an irradiation amount or intensity of the light is at an intensity in which a cytotoxicity value of the sample is greater than or equal to a predetermined value, and a ratio of a degree of deformation of the genetic material of the normal sample to that of the abnormal sample is set to be a minimum value.

First claim

The invention claimed is:

1 . A light emitting device comprising:
an injector configured to inject a sample; and a light emitter configured to apply light to the sample, the light emitter including:
a substrate; and
a light emitting diode disposed on the substrate,
wherein the light emitted from the light emitter is configured to induce genetic damage to a genetic material in the sample, wherein the substrate is configured to dissipate heat from the light emitting diode to reduce heat transfer to the sample, wherein the genetic material is different in size from a normal genetic material in the sample, and the light emitted from the light emitter is configured to cut the genetic material in the sample, wherein an irradiation amount or an irradiation intensity of the light emitted from the light emitter is configured to be provided at an intensity in which a ratio of a degree of deformation of the normal genetic material in the sample to a degree of deformation of the genetic material in the sample is set to be a minimum value outside of an error range, and wherein the light emitted from the light emitter includes at least a range of light in a blue wavelength range to an ultraviolet wavelength range.

2 . The light emitting device of claim 1 , further comprising a pre-processing region configured to process the sample.

3 . The light emitting device of claim 2 , wherein the sample includes blood and leukocyte, and the pre-processing region is configured to separate the leukocyte from whole blood.

4 . The light emitting device of claim 1 , wherein the light emitter includes a first light emitter and a second light emitter having a different peak wavelength from the first light emitter.

5 . The light emitting device of claim 1 , wherein the light corresponds to at least one of light in UVA wavelength, UVB wavelength, and UVC wavelength.

6 . The light emitting device of claim 1 , wherein the sample includes blood.

7 . The light emitting device of claim 1 , wherein the irradiation amount or irradiation intensity of the light is configured to be set within a limit in which cell viability of the normal genetic material is 75% or more.

8 . A light emitting device comprising:
an injector configured to inject a sample; a light emitter configured to apply light to the sample, the light emitter including:
a substrate; and
a light emitting diode disposed on the substrate,
wherein the light emitted from the light emitter is configured to induce genetic damage of a genetic material in the sample, wherein the substrate is configured to dissipate heat from the light emitting diode to reduce heat transfer to the sample, wherein the genetic material is different in size from a normal genetic material in the sample, and the light emitted from the light emitter is configured to cut the genetic material in the sample, wherein an irradiation amount or irradiation intensity of the light is configured to be set within a limit in which cell viability of the normal genetic material object is 75% or more, wherein the irradiation amount or the irradiation intensity of the light emitted from the light emitter is configured to be provided at an intensity in which a ratio of a degree of deformation of the normal genetic material in the sample to a degree of deformation of the genetic material in the sample is set to be a minimum value outside of an error range, and wherein the light emitter includes a first light emitter and a second light emitter having a different peak wavelength from the first light emitter.

9 . The light emitting device of claim 8 , further comprising a pre-processing region configured to process the sample.

10 . The light emitting device of claim 8 , wherein the light emitted from the light emitter includes at least a range of light in a blue wavelength range to an ultraviolet wavelength range.

11 . The light emitting device of claim 10 , wherein the light corresponds to at least one of light in UVA wavelength, UVB wavelength, and UVC wavelength.

12 . The light emitting device of claim 8 , wherein the sample includes blood.

13 . A light emitting device comprising:
an injector configured to inject a sample; and a light emitter configured to apply light to the sample, the light emitter including:
a substrate; and
a light emitting diode disposed on the substrate,
wherein the light emitted from the light emitter is configured to induce genetic damage to a genetic material in the sample, wherein the substrate is configured to dissipate heat from the light emitting diode to reduce heat transfer to the sample, wherein the genetic material is different in size from a normal genetic material in the sample, and the light emitted from the light emitter is configured to cut the genetic material in the sample, wherein an irradiation amount or irradiation intensity of the light is configured to be set within a limit in which cell viability of the normal genetic material is 75% or more, wherein the irradiation amount or the irradiation intensity of the light emitted from the light emitter is configured to be provided at an intensity in which a ratio of a degree of deformation of the normal genetic material in the sample to a degree of deformation of the genetic material in the sample is set to be a minimum value outside an error range, and wherein the light emitted from the light emitter includes at least a range of light in a blue wavelength range to an ultraviolet wavelength range.

14 . The light emitting device of claim 13 , further comprising a pre-processing region configured to process the sample.

15 . The light emitting device of claim 14 , wherein the sample includes blood and leukocyte, and the pre-processing region is configured to separate the leukocyte from whole blood.

16 . The light emitting device of claim 13 , wherein the light emitter includes a first light emitter and a second light emitter having a different peak wavelength from the first light emitter.

17 . The light emitting device of claim 13 , wherein the light corresponds to at least one of light in UVA wavelength, UVB wavelength, and UVC wavelength.

18 . The light emitting device of claim 13 , wherein the sample includes blood.

Assignees

• Seoul Viosys Co Ltd

Inventors

• Bae Hee Ho
• Yoon Yeong Min
• Lee A Young

Classifications

• C12M41/46

  of cellular or enzymatic activity or functionality, e.g. cell viability · CPC title

• G01N2021/0112

  Apparatus in one mechanical, optical or electronic block · CPC title

• G01N27/447

  using electrophoresis · CPC title

• G01N21/6486

  Measuring fluorescence of biological material, e.g. DNA, RNA, cells (G01N21/6428 takes precedence) · CPC title

• G01N21/6428

  Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" (in vivo A61B5/00; immunoassay G01N33/53) · CPC title