Ischemic cardiopathy diagnosis assistance system

Patent metadata

Field	Value
Publication number	US-12458238-B2
Application number	US-201917259988-A
Country	US
Kind code	B2
Filing date	Jul 19, 2019
Priority date	Jul 26, 2018
Publication date	Nov 4, 2025
Grant date	Nov 4, 2025

Abstract

An ischemic cardiopathy diagnosis assistance system includes pressure data acquisition means 11 for acquiring pressure data including proximal pressure Pa in a proximal stenotic segment A 1 and distal pressure Pd in a distal stenotic segment A 2 ; intracoronary electrocardiogram data acquisition means 12 for acquiring intracoronary electrocardiogram data made up of a local intracoronary artery electrocardiogram in a neighborhood of the distal stenotic segment; and computational processing means 14 for finding a pressure ratio Pa/Pd between the proximal pressure Pa and distal pressure Pd at a time suitable for diagnosis of ischemic cardiopathy based on these data. The computational processing means temporally associates the pressure data with the intracoronary electrocardiogram data, estimates an analysis period T during which vascular resistance remains stably low from a waveform of the intracoronary electrocardiogram data, and extract the pressure data of the analysis period T, and finds the pressure ratio Pa/Pd from the pressure data.

First claim

The invention claimed is:

1 . An ischemic cardiopathy diagnosis assistance system that measures intracoronary pressure in a proximal stenotic segment on an upstream side of a stenotic lesion site in a coronary artery of a patient and intracoronary pressure in a distal stenotic segment on a downstream side of the stenotic lesion site in the coronary artery of a patient and finds a pressure ratio between the proximal stenotic segment and the distal stenotic segment as a diagnosis index of ischemic cardiopathy, the assistance system comprising:
pressure data acquisition means for acquiring pressure data including proximal pressure, which is pressure in the proximal stenotic segment, and distal pressure, which is pressure in the distal stenotic segment; intracoronary electrocardiogram data acquisition means for acquiring intracoronary electrocardiogram data made up of a local intracoronary artery electrocardiogram in a neighborhood of the distal stenotic segment; and computational processing means for finding the pressure ratio at a time for diagnosis of ischemic cardiopathy based on the data acquired by the pressure data acquisition means and the data acquired by the intracoronary electrocardiogram data acquisition means, wherein the pressure data acquisition means is a pressure apparatus including a first pressure sensor and a second pressure sensor, the first pressure sensor is configured to be placed in the proximal stenotic segment for acquiring the proximal pressure, the pressure apparatus includes a guide wire coupled with the second pressure sensor, and the second pressure sensor is configured to be placed in the distal stenotic segment for acquiring the distal pressure; the intracoronary electrocardiogram data acquisition means is an intracoronary electrocardiogram data acquisition device including an electrode, a distal side of the guide wire is the electrode configured to be placed in the distal stenotic segment in a unipolar lead mode for acquiring the local intracoronary artery electrocardiogram; and the computational processing means includes:
a pressure data extraction unit configured to temporally associate the pressure data with the intracoronary electrocardiogram data, wherein the intracoronary electrocardiogram data and the pressure data including the proximal pressure and the distal pressure are acquired during a same time period in the coronary artery, estimate an analysis period from a waveform of the intracoronary electrocardiogram data, and extract the pressure data of the analysis period, and
a pressure ratio determination unit configured to find the pressure ratio from the pressure data extracted by the pressure data extraction unit.

2 . The ischemic cardiopathy diagnosis assistance system according to claim 1 , wherein the pressure data extraction unit identifies a zone in which a shape of a waveform of an intracoronary artery electrocardiogram reveals a limited temporal potential change and designates a time slot in the zone as the analysis period.

3 . The ischemic cardiopathy diagnosis assistance system according to claim 1 , wherein the pressure data extraction unit extracts a target zone excluding zones containing a maximum potential and a minimum potential from the intracoronary electrocardiogram data, and within the target zone, identifies a zone in which a potential change remains within a predetermined range from a lowest potential, the zone centering around a time point at which the lowest potential occurs, a span of the predetermined range being less than a predetermined value, and determines a time slot in the zone as the analysis period.

4 . The ischemic cardiopathy diagnosis assistance system according to claim 1 , wherein the pressure data extraction unit extracts a target zone excluding zones containing a maximum potential and a minimum potential from the intracoronary electrocardiogram data, and within the target zone, identifies a zone in which a potential change remains within a predetermined range from a lowest potential, the zone centering around a time point at which the lowest potential occurs, a span of the predetermined range being less than a predetermined value, cuts off opposite ends of the zone or a predetermined time interval before or after the zone, and determines a resulting time slot as the analysis period.

5 . The ischemic cardiopathy diagnosis assistance system according to claim 1 , further comprising blood flow data acquisition means configured to be able to measure blood flow data corresponding to blood flow in the distal stenotic segment, wherein
the pressure data extraction unit extracts the pressure data according to magnitude of the blood flow.

6 . The ischemic cardiopathy diagnosis assistance system according to claim 1 , further comprising blood flow data acquisition means configured to be able to measure blood flow data corresponding to blood flow in the distal stenotic segment, wherein
the pressure data extraction unit calculates intravascular resistance value from the blood flow data and the distal pressure and extracts the pressure data according to magnitude of the intravascular resistance value.

Assignees

• Univ Waseda

Inventors

• Nakayama Masafumi
• Iwasaki Kiyotaka

Classifications

• A61B5/283

  Invasive · CPC title

• A61B5/349

  Detecting specific parameters of the electrocardiograph cycle · CPC title

• A61B5/72

  Signal processing specially adapted for physiological signals or for diagnostic purposes · CPC title

• A61B5/026

  Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)} · CPC title

• A61B5/7285

  for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal · CPC title