Enclosed, multi-chamber metering and mixing system used for urinalysis

Patent metadata

Field	Value
Publication number	US-12455227-B2
Application number	US-202318156692-A
Country	US
Kind code	B2
Filing date	Jan 19, 2023
Priority date	Jan 19, 2023
Publication date	Oct 28, 2025
Grant date	Oct 28, 2025

Abstract

A liquid metering and mixing system for preparing a plurality of samples for analysis. The system includes: a liquid metering apparatus disposed in fluid communication with a sample holder and a plurality of reaction chambers and configured to meter a volume of a liquid into each of the plurality of reaction chambers, wherein each of the plurality of reaction chambers includes a reagent; and a mixing apparatus comprising a plurality of mixing elements, wherein each of the plurality of mixing elements is disposed in a corresponding reaction chamber of the plurality of reaction chambers and is adapted to mix the volume of the liquid with the reagent in preparation for analysis.

First claim

What is claimed is:

1. A liquid metering and mixing system for preparing a plurality of samples for analysis, the system comprising:
a liquid metering apparatus disposed in fluid communication with a sample holder and a plurality of reaction chambers and configured to meter a volume of a liquid into each of the plurality of reaction chambers, wherein each of the plurality of reaction chambers includes a reagent; and
a mixing apparatus comprising a plurality of mixing elements, wherein each of the plurality of mixing elements is disposed in a corresponding reaction chamber of the plurality of reaction chambers and is rotated in the plurality of reaction chambers and is adapted to mix the volume of the liquid with the reagent in preparation for analysis.

2. The system of claim 1 , wherein the liquid metering apparatus is adapted to dispense the liquid into each of the plurality of reaction chambers using gravity induced flow.

3. The system of claim 1 , wherein the liquid metering apparatus is adapted to dispense the liquid into each of the plurality of reaction chambers using a pressure differential between the liquid metering apparatus and each of the plurality of reaction chambers.

4. The system of claim 1 , wherein the liquid metering apparatus includes a distributor in fluid communication with the sample holder that is adapted to distribute the liquid above a plurality of metering reservoirs that are in fluid communication with the plurality of reaction chambers and the plurality of metering reservoirs are each adapted to meter the volume of the liquid into each of the plurality of reaction chambers.

5. The system of claim 1 , wherein the volume of the liquid metered into each of the plurality of reaction chambers is dependent upon the reagent included in each of the plurality of reaction chambers.

6. The system of claim 1 , wherein each of the plurality of mixing elements includes an agitator disposed within the corresponding reaction chamber of the plurality of reaction chambers.

7. The system of claim 1 , wherein the mixing apparatus includes a handlebar that is connected to a gear housing including a series of interconnected gears, the plurality of mixing elements being each attached to one of the series of gears, the mixing apparatus being adapted such that when the handlebar is turned, the series of gears are rotated and cause the plurality of mixing elements to be rotated in the plurality of reaction chambers.

8. The system of claim 1 , wherein the mixing apparatus includes a handle that is connected to a force distributor, the force distributor connected to a plurality of spring and barrel cams that are each connected to one of the plurality of mixing elements, the mixing apparatus being adapted such that when the handlebar is depressed, the force distributor applies a force to the plurality of spring barrel cams that cause the plurality of mixing elements to be rotated in the plurality of reaction chambers.

9. A liquid sample testing system comprising:
a liquid metering apparatus disposed in fluid communication with a sample holder and a plurality of reaction chambers and adapted to meter a volume of a liquid into each of the plurality of reaction chambers, wherein each of the plurality of reaction chambers includes a reagent;
a mixing apparatus comprising a plurality of mixing elements, wherein each of the plurality of mixing elements is disposed in a corresponding reaction chamber of the plurality of reaction chambers and is rotated in the plurality of reaction chambers and is adapted to mix the volume of the liquid with the reagent in preparation for analysis; and
a colorimeter disposed in optical communication with at least one of the plurality of reaction chambers.

10. The system of claim 9 , wherein the liquid metering apparatus is adapted to dispense the liquid into the plurality of reaction chambers using gravity induced flow.

11. The system of claim 9 , wherein the liquid metering apparatus is adapted to dispense the liquid into each of the plurality of reaction chambers using a pressure differential between the liquid metering apparatus and each of the plurality of reaction chambers.

12. The system of claim 9 , wherein each mixing apparatus includes an agitator disposed within each of the plurality of reaction chambers.

13. The system of claim 9 , wherein the liquid metering apparatus is adapted to dispense the volume of the liquid into each of the plurality of reaction chambers according to the reagent in the reaction chamber.

14. The system of claim 9 , wherein the mixing apparatus includes a motion transfer element connected to at least one of the plurality of mixing elements.

15. A method of preparing a liquid sample for analysis, the method comprising:
metering a volume of the liquid sample into each of a plurality of reaction chambers that each include a reagent;
rotating a plurality of mixing elements in each of the plurality of reaction chambers; and
mixing the volume of the liquid sample with the reagent in each of the plurality of reaction chambers.

16. The method of claim 15 , further comprising:
providing a liquid metering apparatus disposed in fluid communication with a sample holder and the plurality of reaction chambers and adapted to meter the volume of the liquid sample into each of the plurality of reaction chambers; and
providing a mixing apparatus comprising a plurality of mixing elements, wherein each of the plurality of mixing elements is disposed in a corresponding reaction chamber of the plurality of reaction chambers and is adapted to mix the volume of the liquid with the reagent in preparation for analysis.

17. The method of claim 16 , further comprising:
dispensing the volume of the liquid sample into each of the plurality of reaction chambers using a pressure differential between the liquid metering apparatus and each of the plurality of reaction chambers.

18. The method of claim 16 , further comprising:
dispensing the volume of the liquid sample into each of the plurality of reaction chambers using gravity induced flow.

19. The method of claim 16 , further comprising:
mixing the volume of the liquid sample with the reagent using a handlebar that is connected to a gear housing including a series of interconnected gears, the plurality of mixing elements being each attached to one of the series of gears, the mixing apparatus being adapted such that when the handlebar is turned, the series of gears are rotated and cause the plurality of mixing elements to be rotated in the plurality of reaction chambers.

20. The method of claim 16 , further comprising:
mixing the volume of the liquid sample with the reagent using a handle bar that is connected to a force distributor, the force distributor connected to a plurality of spring and barrel cams that are each connected to one of the plurality of mixing elements, the mixing apparatus being adapted such that when the handlebar is depressed, the force distributor applies a force to the plurality of spring barrel cams that cause the plurality of mixing elements to be rotated in the plurality of reaction chambers.

Assignees

• IBM

Inventors

• Siu Vince
• Dang Bing
• Wen Bo
• Hsieh Kuan Yu

Classifications

• G01N21/03

  Cuvette constructions · CPC title

• G01N21/251

  Colorimeters; Construction thereof · CPC title

• G01N2021/0325

  Cells for testing reactions, e.g. containing reagents · CPC title

• G01N1/38

  Diluting, dispersing or mixing samples · CPC title

• B01F2101/23

  Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials · CPC title