3β-(4-methoxybenzyloxy)pregn-5-en-20-one for use in the treatment of Cannabinoids-Related Disorders

Patent metadata

Field	Value
Publication number	US-12447159-B2
Application number	US-202217945339-A
Country	US
Kind code	B2
Filing date	Sep 15, 2022
Priority date	Feb 20, 2018
Publication date	Oct 21, 2025
Grant date	Oct 21, 2025

Abstract

The present invention generally relates to a specific pregnenolone derivative for its use for the treatment of a Cannabinoids-Related Disorder. More particularly, the invention relates to a compound of Formula (I)

for its use in the treatment of a Cannabinoids-Related Disorder. Indeed, the compound of the invention is in vivo very potent in inhibiting the effects of THC, and is able to inhibit both unconditioned and conditioned effects of THC including THC self-administration and reinstatement in THC seeking in non-human primates.

First claim

What is claimed is:

1. A method for treating a Cannabinoids-Related Disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to Formula (I):

wherein the compound is administered to the subject at a dose between 10 g to 10 mg.

2. The method of claim 1 , wherein the compound is administered to the subject at a dose between 10 μg to 5 mg.

3. The method of claim 1 , wherein the compound is administered to the subject at a dose between 10 μg to 1 mg.

4. The method of claim 1 , wherein the compound is administered to the subject at a dose between 10 μg to 600 μg.

5. The method of claim 1 , wherein the compound is administered to the subject at a dose between 10 μg to 200 μg.

6. The method of claim 1 , wherein the compound is administered to the subject at a dose between 10 μg to 100 μg.

7. The method of claim 1 , wherein the compound is administered to the subject from 1 to 4 times per day.

8. The method of claim 7 , wherein the dose is administered to the subject 1 time per day.

9. The method of claim 1 , wherein the Cannabinoids-Related Disorder is selected from the group consisting of Cannabinoids Use Disorder, Cannabinoids Intoxication, Cannabinoids Withdrawal, Other Cannabinoids-Induced Disorder, Unspecified Cannabinoids-Related Disorder, Cannabinoids Hyperemesis Syndrome, and Cannabinoids-Induced Catatonia.

10. The method of claim 9 , wherein the Cannabinoids-Related Disorder is Cannabinoids Use Disorder.

11. The method of claim 9 , wherein the Cannabinoids-Related Disorder is Cannabinoids Intoxication.

12. The method of claim 9 , wherein the Cannabinoids-Related Disorder is Cannabinoids Withdrawal.

13. The method of claim 9 , wherein the Cannabinoids-Related Disorder is an Other Cannabinoids-Induced Disorder selected from the group consisting of cannabinoids-induced anxiety disorder, cannabinoids-induced psychotic disorder, cannabinoids-induced sleep disorder, and cannabinoids intoxication delirium.

14. The method of claim 9 , wherein the Cannabinoids-Related Disorder is an Unspecified Cannabinoids-Related Disorder.

15. The method of claim 9 , wherein the Cannabinoids-Related Disorder is a Cannabinoids Hyperemesis Syndrome.

16. The method of claim 9 , wherein the Cannabinoids-Related Disorder is a Cannabinoids-Induced Catatonia.

17. The method of claim 1 , wherein the Cannabinoids-Related Disorder is a disorder associated with the use of cannabinoids derived from a Cannabis L. plant.

18. The method of claim 1 , wherein the Cannabinoids-Related Disorder is a disorder associated with the use of a synthetic cannabinoid with CB1 agonist activity.

19. The method of claim 1 , wherein the compound is administered to the subject via an oral route.

20. The method of claim 1 , wherein the compound is administered to the subject via a parenteral route either with a readily absorbable formulation or a depot-type formulation.

21. The method of claim 1 , wherein the compound is administered intravenously, subcutaneously, or intramuscularly.

22. The method of claim 1 , wherein the compound is administered intranasally, by inhalation, sublingually, topically, transdermally, or in the form of a suppository or pessary.

23. The method of claim 1 , wherein the compound is administered in an oleaginous vehicle.

24. The method of claim 23 , wherein the oleaginous vehicle is a long chain triglyceride vegetable oil.

Assignees

• Aelis Farma
• Inst Nat Sante Rech Med
• Univ Bordeaux

Inventors

• Piazza Pier Vincenzo
• Fabre Sandy
• Metna Mathilde
• Monlezun Stephanie
• Busquet-Garcia Arnau
• Cota Daniela
• Marsicano Giovanni
• Revest Jean-Michel
• Vallee Monique

Classifications

• A61P25/30

  for treating abuse or dependence · CPC title

• A61K36/13

  Coniferophyta (gymnosperms) · CPC title

• A61K31/57 Primary

  substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone · CPC title