3β-(4-methoxybenzyloxy)pregn-5-en-20-one for use in the treatment of cannabinoids-related disorders

Patent metadata

Field	Value
Publication number	US-11484537-B2
Application number	US-201916968237-A
Country	US
Kind code	B2
Filing date	Feb 20, 2019
Priority date	Feb 20, 2018
Publication date	Nov 1, 2022
Grant date	Nov 1, 2022

Abstract

The present invention generally relates to a specific pregnenolone derivative for its use for the treatment of a Cannabinoids-Related Disorder. More particularly, the invention relates to a compound of Formula (I)for its use in the treatment of a Cannabinoids-Related Disorder. Indeed, the compound of the invention is in vivo very potent in inhibiting the effects of THC, and is able to inhibit both unconditioned and conditioned effects of THC including THC self-administration and reinstatement in THC seeking in non-human primates.

First claim

The invention claimed is:

1. A method for treating a Cannabinoids-Related Disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to Formula (I):

2. The method of claim 1 , wherein the Cannabinoids-Related Disorder is selected from the group consisting of Cannabinoids Use Disorder, Cannabinoids Intoxication, Cannabinoids Withdrawal, Other Cannabinoids-Induced Disorder, Unspecified Cannabinoids-Related Disorder, Cannabinoids Hyperemesis Syndrome, and Cannabinoids-Induced Catatonia.

3. The method of claim 2 , wherein the Cannabinoids-Related Disorder is Cannabinoids Use Disorder.

4. The method of claim 2 , wherein the Cannabinoids-Related Disorder is Cannabinoids Intoxication.

5. The method of claim 2 , wherein the Cannabinoids-Related Disorder is Cannabinoids Withdrawal.

6. The method of claim 2 , wherein the Cannabinoids-Related Disorder is an Other Cannabinoids-Induced Disorder selected from the group consisting of cannabinoids-induced anxiety disorder, cannabinoids-induced psychotic disorder, cannabinoids-induced sleep disorder, and cannabinoids intoxication delirium.

7. The method of claim 2 , wherein the Cannabinoids-Related Disorder is an Unspecified Cannabinoids-Related Disorder.

8. The method of claim 2 , wherein the Cannabinoids-Related Disorder is a Cannabinoids Hyperemesis Syndrome.

9. The method of claim 2 , wherein the Cannabinoids-Related Disorder is a Cannabinoids-Induced Catatonia.

10. The method of claim 1 , wherein the Cannabinoids-Related Disorder is a disorder associated with the use of cannabinoids derived from Cannabis L. plant.

11. The method of claim 1 , wherein the Cannabinoids-Related Disorder is a disorder associated with the use of synthetic cannabinoids with CB1 agonist activity.

12. The method of claim 1 , wherein said compound is administered to the subject via an oral route.

13. The method of claim 1 , wherein said compound is administered to the subject via a parenteral route either with a ready absorbable formulation or a depot-type formulation.

14. The method of claim 1 , wherein said compound is administered intravenously, subcutaneously, or intramuscularly.

15. The method of claim 1 , wherein said compound is administered intranasally, by inhalation, sublingually, topically, transdermally, or in the form of a suppository or pessary.

16. The method of claim 1 , wherein said compound is administered to the subject at a dose between 1 μg to 1000 mg.

17. The method of claim 1 , wherein said compound is administered in an oleaginous vehicle.

18. The method of claim 17 , wherein the oleaginous vehicle is a long chain triglyceride vegetable oil.

19. The method of claim 18 , wherein the long chain triglyceride vegetable oil is corn oil.

Assignees

• Aelis Farma
• Inst Nat Sante Rech Med
• Univ Bordeaux

Inventors

• Piazza Pier Vincenzo
• Fabre Sandy
• Metna Mathilde
• Monlezun Stéphanie
• Busquet-Garcia Arnau
• Cota Daniela
• Marsicano Giovanni
• Revest Jean-Michel
• Vallée Monique

Classifications

• A61K36/13

  Coniferophyta (gymnosperms) · CPC title

• A61P25/30

  for treating abuse or dependence · CPC title

• A61K31/57 Primary

  substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone · CPC title