Screening Assay for Choice of Prebiotic to Prevent/Treat Gastrointestinal and Systemic Diseases
US-2017184569-A1 · Jun 29, 2017 · US
Probiotic compositions for production of dopamine
US12440519B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12440519-B2 |
| Application number | US-202217662188-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 5, 2022 |
| Priority date | Sep 22, 2017 |
| Publication date | Oct 14, 2025 |
| Grant date | Oct 14, 2025 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention is directed to synbiotic compositions of probiotic strains and prebiotics, along with uses thereof for targeted human and animal applications, for example, in promoting health and well-being and/or treating therapeutic conditions. The present invention is also directed to methods of probiotic selection and detection of strains with the ability to produce neurochemicals in the gastrointestinal tract of a subject, providing a microbial endocrinology-based mechanism and approach for optimization of synbiotic delivery of a probiotic with a neurochemical precursor. Still further the present invention is directed to industrial applications for production of dopamine utilizing methods and media suitable for the same.
First claim
Opening claim text (preview).
What is claimed is: 1. A synbiotic composition comprising: from about 10 4 CFU to about 10 12 CFU of at least one bacterial strain comprising an Enterococcus spp. and/or a Vagococcus spp., wherein the bacterial strain produces dopamine; and a time release prebiotic component comprising from about 1 mg/kg to about 100 mg/kg of L-DOPA. 2. The composition of claim 1 , further comprising a co-factor of dopamine, wherein said co-factor is pyridoxal phosphate. 3. The composition of claim 1 , wherein the composition is in an oral dosage in liquid or solid form. 4. The composition of claim 1 , wherein the prebiotic is derived from a food source. 5. The composition of claim 4 , wherein the food source is an herbal or plant source. 6. The composition of claim 1 , wherein the synbiotic composition is contained in a time release tablet or capsule.
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Classifications
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate · CPC title
Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title
Mouth and digestive tract, i.e. intraoral and peroral administration · CPC title
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
involving cells · CPC title
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- What does patent US12440519B2 cover?
- The present invention is directed to synbiotic compositions of probiotic strains and prebiotics, along with uses thereof for targeted human and animal applications, for example, in promoting health and well-being and/or treating therapeutic conditions. The present invention is also directed to methods of probiotic selection and detection of strains with the ability to produce neurochemicals in …
- Who is the assignee on this patent?
- Univ Iowa State Res Found Inc, Lowa State Univ Research Foundation Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K35/744. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 14 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).