Canine probiotic bifidobacterium pseudolongum

Patent metadata

Field	Value
Publication number	US-9580680-B2
Application number	US-29217108-A
Country	US
Kind code	B2
Filing date	Nov 13, 2008
Priority date	Dec 19, 2003
Publication date	Feb 28, 2017
Grant date	Feb 28, 2017

Abstract

According to the invention there is provided a strain of lactic acid bacteria of the species Bifidobacterium pseudolongum obtainable by isolation from resected and washed canine gastrointestinal tract having a probiotic activity in animals. Methods of use and compositions comprising the Bifidobacterium pseudolongum of the present invention are also provided.

First claim

The invention claimed is:

1. A food composition comprising:
a biologically pure culture of strain Bifidobacterium pseudolongum AHC7, NCIMB 41199, or mutant strain thereof, wherein the strain has probiotic activity in a companion animal selected from a canine, a feline, a rabbit, a ferret, a horse, and a cow; and
a component comprising protein, fat, and carbohydrate,
wherein the food composition is in a form selected from a biscuit, a kibble, a yogurt, a gravy, and any combination thereof, and further
wherein the Bifidobacterium pseudolongum strain survives and colonizes the gastrointestinal tract of the companion animal.

2. The food composition according to claim 1 , wherein the strain adheres to gut epithelial cells of the companion animal at a level of at least 4%.

3. The food composition according to claim 1 , wherein the strain has a growth of at least 33% in the presence of 0.5% bile salts.

4. The composition according to claim 1 , wherein the strain is able to maintain viability following 1 hour at pH 2.5.

5. The food composition of claim 1 , wherein the mutant strain is a natural, genetically modified, or induced mutant strain.

6. The food composition of claim 1 , wherein the companion animal is a dog.

7. The food composition of claim 1 , wherein the companion animal is a cat.

8. A composition comprising
a biologically pure culture of strain Bifidobacterium pseudolongum AHC7, NCIMB 41199, or a mutant strain thereof, and
a food composition comprising protein, fat, and carbohydrate, wherein the food composition is in a form selected from
a biscuit, a kibble, a yogurt, a gravy, a dairy product, and any combination thereof;
wherein the strain is present in an amount effective to have probiotic activity in a companion animal selected from a canine, a feline, a rabbit, a ferret, a horse, and a cow, and
wherein the strain survives and colonizes the gastrointestinal tract of the companion animal.

9. The composition according to claim 8 , wherein the strain adheres to gut epithelial cells of the companion animal at a level of at least 4%.

10. The composition according to claim 8 , wherein the strain has a growth of at least 33% in the presence of 0.5% bile salts.

11. The composition according to claim 8 , wherein the strain is able to maintain viability following 1 hour at pH 2.5.

12. The composition according to claim 8 , wherein the mutant strain is a natural, genetically modified, or induced mutant strain.

13. The composition according to claim 8 , wherein the companion animal is a dog.

14. The composition according to claim 8 , wherein the companion animal is a cat.

15. The composition according to claim 8 , wherein the composition is a companion animal food.

16. The composition according to claim 15 , wherein the composition is a dog food.

17. The composition according to claim 15 , wherein the composition is a cat food.

18. The composition according to claim 8 , wherein the composition is a gravy.

19. The composition according to claim 8 , further comprising at least one of a metabolite, a homogenate, a protein, an extract, and a ferment supernatant of the strain Bifidobacterium pseudolongum AHC7, NCIMB 41199, or a mutant strain thereof.

20. A composition comprising:
the isolated strain of Bifidobacterium pseudolongum AHC7, NCIMB 41199; and a component comprising protein, fat, and carbohydrate,
wherein the composition is in a form selected from a biscuit, a kibble, a yogurt, a gravy, and any combination thereof,
wherein the isolated strain has probiotic activity in a companion animal selected from a canine, a feline, a rabbit, a ferret, a horse, and a cow, and wherein the strain survives and colonizes the gastrointestinal tract of the companion animal.

Assignees

• Boileau Thomas William-Maxwell
• Ceddia Michael Anthony
• Collins John Kevin
• Davenport Gary Mitchell
• Kiely Barry Pius
• O'Mahony Liam Diarmuid
• Sunvold Gregory Dean
• Tetrick Mark Alan
• Vickers Robert Jason
• Mars Inc

Inventors

• Boileau Thomas William-Maxwell
• Ceddia Michael Anthony
• Collins John Kevin
• Davenport Gary Mitchell
• Kiely Barry Pius
• O'Mahony Liam Diarmuid
• Sunvold Gregory Dean
• Tetrick Mark Alan
• Vickers Robert Jason

Classifications

• A61P31/12

  Antivirals · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P5/14

  of the thyroid hormones, e.g. T3, T4 · CPC title