Powdered thickener maintaining its extensional properties when reconstituted and for promoting safe swallowing by individuals with dysphagia

Patent metadata

Field	Value
Publication number	US-12433314-B2
Application number	US-201917413078-A
Country	US
Kind code	B2
Filing date	Dec 3, 2019
Priority date	Dec 13, 2018
Publication date	Oct 7, 2025
Grant date	Oct 7, 2025

Abstract

A thickening powder promotes safe swallowing of a nutritional product by an individual with dysphagia and can be used in methods of treating dysphagia, promoting safe swallowing of a nutritional product, and mitigating a risk of aspiration during swallowing of a nutritional product. The powder contains beta-glucan and at least one carrier ingredient in an amount that is neutral toward or enhances the extensional properties of the nutritional product. The at least one carrier ingredient can be one or more of maltodextrin, isomaltulose, sucrose or lactose. The powder can be diluted in a diluent to form an aqueous solution that is at least a portion of a nutritional product and to improve the cohesiveness of the nutritional product. Preferably, the resultant nutritional product has a shear viscosity greater than 200 mPas and up to about 2,000 mPas, preferably greater than 200 mPas and up to about 500 mPas, more preferably 250 mPas to about 450 mPas, most preferably 250 mPas to about 400 mPas, when measured at a shear rate of 50 s −1 at a temperature of 20° C.

First claim

The invention is claimed as follows:

1. A method of treating a swallowing disorder or mitigating a risk of aspiration during swallowing in an individual having the swallowing disorder, the method comprising orally administering to the individual a nutritional product in which at least a portion thereof is made by diluting a thickening powder comprising a beta-glucan and at least one carrier ingredient in a weight ratio of about 10:1 to about 300:1 with a diluent to form an aqueous solution, wherein the weight ratio of diluent:thickening powder is from 50:1 to 100:1, wherein the diluting the thickening powder comprises diluting a unit dosage form of the thickening powder that is an amount effective for administration of the nutritional product to an individual who suffers from dysphagia to achieve at least one of (i) supplemental nutrition, (ii) hydration and (ii) replacement of one or more full meals, the nutritional product comprising an amount of the aqueous solution that is neutral toward or enhances extensional properties of the nutritional product and provides to the nutritional product a shear viscosity greater than 200 mPas and up to about 2,000 mPas at a shear rate of 50 s −1 at 20° C.,
wherein the at least one carrier ingredient comprises isomaltulose.

2. The method according to claim 1 , wherein the shear viscosity provided by the aqueous solution to the nutritional product is greater than 200 mPas and up to about 500 mPas when measured at a shear rate of 50 s −1 .

3. The method according to claim 1 , wherein the amount of the aqueous solution in the nutritional product provides to the nutritional product a relaxation time determined by a Capillary Breakup Extensional Rheometry (CaBER) experiment of about 10 to about 2,000 milliseconds (ms) at 20° C.

4. The method according to claim 1 , wherein the diluent is one or more of (1) water, (2) milk, (3) a beverage comprising water and further comprising at least one component additional to the water, (4) a liquid oral nutritional supplement (ONS), or (5) a food product, and the diluting the thickening powder with the diluent directly forms the nutritional product such that the nutritional product consists essentially of the diluent, the beta-glucan, and the at least one carrier ingredient.

5. The method according to claim 1 , wherein the diluting the thickening powder with the diluent to form the aqueous solution is followed by addition of the aqueous solution to at least one other orally administrable composition to form the nutritional product, such that the nutritional product consists essentially of the diluent, the beta-glucan, the at least one carrier ingredient, and the at least one other orally administrable composition.

6. The method according to claim 1 , wherein the nutritional product is a ready-to-drink beverage made by packaging the nutritional product after the diluting the thickening powder with the diluent.

Assignees

• Nestle Sa

Inventors

• Burbidge Adam
• Jedwab Michael
• Engmann Jan

Classifications

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23L33/125

  containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates (indigestible substances A23L33/21) · CPC title

• A61P1/06

  Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia · CPC title

• A23L29/269

  of microbial origin, e.g. xanthan or dextran · CPC title

• A23L29/271 Primary

  Curdlan; beta-1-3 glucan; Polysaccharides produced by agrobacterium or alcaligenes · CPC title