Sliding band capacitor inductive coupling in a low temperature nuclear magnetic resonance probe and methods of use

Patent metadata

Field	Value
Publication number	US-12422508-B1
Application number	US-202418599786-A
Country	US
Kind code	B1
Filing date	Mar 8, 2024
Priority date	Aug 26, 2022
Publication date	Sep 23, 2025
Grant date	Sep 23, 2025

Abstract

In various embodiments of the invention, a cooled nuclear magnetic resonance (NMR) probe can utilize a sliding band capacitor which can be moved relative to a parent coil inner conductance tapered skirt to adjust the frequency of the parent coil to allow the parent coil to detect the resonance of at least two nuclei without requiring leads between the parent coil and a lock coil. In this manner a cooled NMR probe can be provided without the disadvantages of prior art cooled NMR probes. In an embodiment of the invention, the sliding band capacitor comprises a diamagnetic insulator with a first volume magnetic susceptibility, at least one paramagnetic metal with a second volume magnetic susceptibility and at least one diamagnetic metal with a third volume magnetic susceptibility, where the sum of the first volume magnetic susceptibility, the second volume magnetic susceptibility and the third volume magnetic susceptibility is approximately zero.

First claim

What is claimed is:

1. A NMR probe (Nuclear Magnetic Resonance probe) adapted to detect a resonance of at least a nucleus from a sample, comprising:
(i) a parent coil circuit comprising a parent coil, where the parent coil comprises a tapered inner conductance skirt;
(ii) a cell adapted for holding the sample at a temperature; and
(iii) a sliding band capacitor adapted to adjust a frequency of the parent coil, where the sliding band capacitor comprises a diamagnetic insulator with a first volume magnetic susceptibility, at least one paramagnetic metal with a second volume magnetic susceptibility and at least one diamagnetic metal with a third volume magnetic susceptibility, where the at least one paramagnetic metal is adapted to form a paramagnetic metal ring, where the paramagnetic metal ring comprises a titanium composition by volume between:
a lower limit of greater than approximately eighty (80) percent; and
an upper limit of greater than approximately ninety-eight (98) percent, where a sum of the first volume magnetic susceptibility and the second volume magnetic susceptibility and the third volume magnetic susceptibility is approximately zero, where the NMR probe is adapted to introduce the sample into a magnetic field of a NMR instrument, where the sliding band capacitor is adapted to physically move relative to the tapered inner conductance skirt to adjust a capacitance of the sliding band capacitor to allow the parent coil to detect the resonance of at least the nucleus from the sample.

2. The NMR probe of claim 1 , where the paramagnetic metal ring is enclosed by the at least one diamagnetic metal.

3. The NMR probe of claim 1 , where the paramagnetic metal ring is surrounded by the at least one diamagnetic metal.

4. The NMR probe of claim 1 , where the at least one paramagnetic metal further comprises a metal selected from the group consisting of aluminum, palladium, platinum, rhodium, tantalum, and tungsten.

5. The NMR probe of claim 1 , where a RF field symmetry of the magnetic field is minimally affected by a position of the sliding band capacitor moving relative to the tapered inner conductance skirt.

6. The NMR probe of claim 1 , where the sum is between:
a lower limit of approximately 1×10 −6 at 80 K; and
an upper limit of approximately 1×10 −5 at 80 K.

7. The NMR probe of claim 1 , where the temperature of the sliding band capacitor is approximately 300 K when the NMR probe is introduced into the NMR instrument, where the temperature of the sliding band capacitor prior to detection of the resonance is reduced to between:
a lower limit of approximately 15 K; and
an upper limit of approximately 80 K.

8. The NMR probe of claim 1 , where the at least one diamagnetic metal has an electrical conductance at 300 K of between:
a lower limit of approximately 1×10 7 S/m; and
an upper limit of approximately 1×10 8 S/m.

9. The NMR probe of claim 1 , where the at least one diamagnetic metal is selected from the group consisting of copper, gold, nickel, silver, and zinc.

10. The NMR probe of claim 1 , where the at least one diamagnetic metal is an alloy, where the alloy comprises copper and silver.

11. The NMR probe of claim 1 , where the at least one diamagnetic metal is copper.

12. The NMR probe of claim 1 , where the diamagnetic insulator is selected from the group consisting of sapphire, quartz, diamond, boron nitride, silicon nitride, and alumina.

13. The NMR probe of claim 1 , where the at least one paramagnetic metal is an alloy, where the alloy comprises aluminum and titanium.

14. The NMR probe of claim 1 , where the nucleus is selected from the group consisting of 1 H, 19 F, and 13 C.

15. A NMR probe (Nuclear Magnetic Resonance probe) adapted to detect a resonance of at least a nucleus from a sample, comprising:
(i) a parent coil circuit comprising a parent coil, where the parent coil comprises a tapered inner conductance skirt;
(ii) a cell adapted for holding the sample; and
(iii) a sliding band capacitor adapted to adjust a frequency of the parent coil, where the sliding band capacitor comprises a sapphire insulator with a first volume magnetic susceptibility, at least one paramagnetic metal with a second volume magnetic susceptibility and at least one diamagnetic metal with a third volume magnetic susceptibility, where a sum of the first volume magnetic susceptibility and the second volume magnetic susceptibility and the third volume magnetic susceptibility is approximately zero, where the at least one paramagnetic metal is shaped in a form of a paramagnetic metal ring, where the paramagnetic metal ring is enclosed or surrounded by the at least one diamagnetic metal, where the paramagnetic metal ring comprises a titanium composition by volume between:
a second lower limit of greater than approximately eighty (80) percent; and
a second upper limit of greater than approximately ninety-eight (98) percent, where the sliding band capacitor is at a temperature, where the temperature of the sliding band capacitor is approximately 300° K when the NMR probe is introduced into a NMR instrument, where the temperature of the sliding band capacitor prior to detection of the resonance is reduced to between:
a first lower limit of approximately 15 K;
a first upper limit of approximately 80 K, where the NMR probe is adapted to introduce the sample into a magnetic field of the NMR instrument, where the sliding band capacitor is adapted to physically move relative to the tapered inner conductance skirt to adjust a capacitance of the sliding band capacitor to allow the parent coil to detect the resonance of at least the nucleus from the sample.

16. A method of detecting a resonance of at least a nucleus from a sample using a cooled NMR probe (Nuclear Magnetic Resonance probe), comprising:
(i) selecting a parent coil circuit comprising a parent coil, where the parent coil comprises a tapered inner conductance skirt;
(ii) selecting the sample;
(iii) loading the sample into the NMR probe;
(iv) introducing the NMR probe into a magnetic field of a NMR instrument, where the parent coil circuit is in electrical contact with the tapered inner conductance skirt, where a sliding band capacitor comprises a diamagnetic insulator with a first volume magnetic susceptibility, at least one paramagnetic metal with a second volume magnetic susceptibility and at least one diamagnetic metal with a third volume magnetic susceptibility, where a sum of the first volume magnetic susceptibility and the second volume magnetic susceptibility and the third volume magnetic susceptibility is approximately zero, where the at least one paramagnetic metal is adapted to form a paramagnetic metal ring, where the paramagnetic metal ring comprises a titanium composition by volume between:
a lower limit of greater than approximately eighty (80) percent; and
an upper limit of greater than approximately ninety-eight (98) percent, where the paramagnetic metal ring is enclosed or surrounded by the at least one diamagnetic metal, where the sliding band capacitor is adapted to be cooled to a temperature;
(v) spinning the sample; and
(vi) exciting the sample with a Radio Frequency (RF) field at a Larmor frequency, where the NMR probe is adapted to introduce the sample into the magnetic field of the NMR instrument, where the sliding band capacitor is adapted to physically move relative to the tapered inner conductance skirt to adjust a capacitance of the sliding band capacitor to allow the parent coil to detect the resonance of at least the nucleus from the sample.

Assignees

• Jeol Ltd

Inventors

• Zens Albert

Classifications

• G01R33/34015

  Temperature-controlled RF coils · CPC title

• G01R33/34007

  Manufacture of RF coils, e.g. using printed circuit board technology; additional hardware for providing mechanical support to the RF coil assembly or to part thereof, e.g. a support for moving the coil assembly relative to the remainder of the MR system · CPC title

• G01R33/3628

  Tuning/matching of the transmit/receive coil · CPC title

• G01R33/3635 Primary

  Multi-frequency operation · CPC title

• G01R33/34092 Primary

  RF coils specially adapted for NMR spectrometers · CPC title