Magnetic coupling high resolution nuclear magnetic resolution probe and method of use

Patent metadata

Field	Value
Publication number	US-10656107-B2
Application number	US-201916362919-A
Country	US
Kind code	B2
Filing date	Mar 25, 2019
Priority date	Apr 15, 2015
Publication date	May 19, 2020
Grant date	May 19, 2020

Abstract

In an embodiment of the invention inductive coupling of an idler coil to a parent coil is used to provide a double resonance circuit without the disadvantages of capacitive coupling to the parent coil. In an embodiment of the invention, an inductive coupling coil can be used to achieve a double-tuned circuit. In an embodiment of the invention, a circuit uses inductive coupling to achieve a double resonance circuit for 1H, 19F, and 13C experiments where one of the three nuclei are observed and the other two are decoupled. In an embodiment of the invention a pivot or a shunt can be used to couple and decouple the idler coil and the parent coil.

First claim

What is claimed is:

1. A method to switch between detecting (i) a high performance Nuclear Magnetic Resonance (NMR) spectrum of a sample, and (ii) a decoupled NMR spectrum of a sample, comprising:
(a) introducing a sample into a Nuclear Magnetic Resonance (NMR) probe comprising:
(1) a parent coil circuit including a parent coil and a first capacitor;
(2) a closed idler coil circuit including an idler coil and a second capacitor;

(b) introducing the NMR probe into a magnetic field;
(c) exciting a first resonance mode of a first nuclei of two or more nuclei of the sample with a Radio Frequency (RF) pulse;
(d) detecting a high performance first NMR spectrum, where a coupling constant is zero;
(e) moving the idler coil to inductively couple the idler coil with the parent coil to adjust the coupling constant to a non zero value to decouple a second resonance mode of a second nuclei of the two or more nuclei of the sample from the first resonance mode; and
(f) detecting a second NMR spectrum including the decoupled first resonance mode.

2. The method of claim 1 , wherein the first resonance mode and the second resonance mode are selected from a group consisting of 1 H and 19 F.

3. The method of claim 1 , wherein the first resonance mode and the second resonance mode are selected from a group consisting of 1 H and 2 H.

4. The method of claim 1 , wherein the first resonance mode and the second resonance mode are selected from a group consisting of 1 H and 13 C.

5. The method of claim 1 , wherein the first resonance mode and the second resonance mode are selected from a group consisting of 1 H and 31 P.

6. The method of claim 1 , wherein the first resonance mode and the second resonance mode are selected from a group consisting of 19 F and 31 P.

7. The method of claim 1 , wherein the first resonance mode and the second resonance mode are selected from a group consisting of 13 C and 19 F.

8. A method to measure a Nuclear Magnetic Resonance (NMR) spectrum of a first nuclei decoupled from a second nuclei, comprising:
(a) introducing a sample into a Nuclear Magnetic Resonance (NMR) probe comprising:
(1) a parent coil circuit including a parent coil and a first capacitor;
(2) a closed idler coil circuit including an idler coil and a second capacitor;

(b) introducing the NMR probe into a magnetic field;
(c) exciting a first resonance mode of the first nuclei of two or more nuclei of the sample with a Radio Frequency (RF) pulse;
(d) detecting the first resonance mode, where a coupling constant is zero;
(e) decoupling a second resonance mode of a second nuclei of the two or more nuclei of the sample from the first resonance mode by moving the idler coil to inductively couple the idler coil with the parent coil and adjust the coupling constant to a non zero value; and
(f) detecting a NMR spectrum including the decoupled first resonance mode.

9. The method of claim 8 , wherein the first resonance mode is 13 C and the second resonance mode is 1 H.

10. The method of claim 8 , wherein the first resonance mode is 13 C and the second resonance mode is 19 F.

11. The method of claim 8 , wherein the first resonance mode is 15 N and the second resonance mode is 1 H.

12. The method of claim 8 , wherein the first resonance mode is 15 N and the second resonance mode is 19 F.

13. The method of claim 8 , wherein the first resonance mode is 31 P and the second resonance mode is 1 H.

14. The method of claim 8 , wherein the first resonance mode is 31 P and the second resonance mode is 19 F.

15. A method to measure a Nuclear Magnetic Resonance (NMR) spectrum of a first nuclei decoupled from a second nuclei and a third nuclei, comprising:
(a) introducing a sample into a Nuclear Magnetic Resonance (NMR) probe comprising:
(1) a parent coil circuit including a parent coil and a first capacitor;
(2) a closed idler coil circuit including an idler coil and a second capacitor;

(b) introducing the NMR probe into a magnetic field;
(c) exciting a first resonance mode of a first nuclei of three or more nuclei of the sample with a Radio Frequency (RF) pulse;
(d) detecting the first resonance mode, where a coupling constant is zero;
(e) decoupling a second resonance mode of a second nuclei of the three or more nuclei of the sample and a third resonance mode of a third nuclei of the three or more nuclei of the sample from the first resonance mode by moving the idler coil to inductively couple the idler coil with the parent coil and adjust the coupling constant to a non zero value; and
(f) detecting a NMR spectrum including the decoupled first resonance mode.

16. The method of claim 15 , wherein the first resonance mode is 13 C, the second resonance mode is 1 H and the third resonance mode is 19 F.

17. The method of claim 15 , wherein the first resonance mode is 13 C, the second resonance mode is 19 F and the third resonance mode is 1 H.

18. The method of claim 15 , wherein the first resonance mode is 15 N, the second resonance mode is 1 H and the third resonance mode is 19 F.

19. The method of claim 15 , wherein the first resonance mode is 15 N, the second resonance mode is 19 F and the third resonance mode is 1 H.

20. The method of claim 15 , wherein the first resonance mode is 31 P, the second resonance mode is 19 F and the third resonance mode is 1 H.

21. The method of claim 15 , wherein the first resonance mode is 31 P, the second resonance mode is 1 H and the third resonance mode is 19 F.

Assignees

• Jeol Ltd
• Joel Ltd

Inventors

• Zens Albert

Classifications

• G01R33/3642

  Mutual coupling or decoupling of multiple coils, e.g. decoupling of a receive coil from a transmission coil, or intentional coupling of RF coils, e.g. for RF magnetic field amplification · CPC title

• G01R33/3635 Primary

  Multi-frequency operation · CPC title

• G01N24/08 Primary

  by using nuclear magnetic resonance (G01N24/12 takes precedence) · CPC title

• G01R33/4616

  using specific RF pulses or specific modulation schemes, e.g. stochastic excitation, adiabatic RF pulses, composite pulses, binomial pulses, Shinnar-le-Roux pulses, spectrally selective pulses not being used for spatial selection · CPC title

• G01R33/38

  Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field · CPC title