Engineered skin equivalent, method of manufacture thereof and products derived therefrom

Patent metadata

Field	Value
Publication number	US-12410317-B2
Application number	US-202418649499-A
Country	US
Kind code	B2
Filing date	Apr 29, 2024
Priority date	Apr 21, 2016
Publication date	Sep 9, 2025
Grant date	Sep 9, 2025

Abstract

Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.

First claim

What is claimed is:

1. A method of forming a tanned synthetic leather, wherein the method comprises:
culturing a fibroblast on a scaffold; and
tanning a collagenous extracellular matrix comprising collagen secreted by the fibroblast to generate the tanned synthetic leather.

2. The method of claim 1 , wherein the scaffold comprises a natural material, a synthetic material, or a combination thereof.

3. The method of claim 2 , wherein the scaffold comprises the natural material.

4. The method of claim 2 , wherein the scaffold comprises the synthetic material.

5. The method of claim 1 , wherein the tanning comprises a vegetable tanning, a chrome tanning, an aldehyde tanning, a syntan tanning, a bacterial tanning, or any combination thereof.

6. The method of claim 1 , wherein a thickness of the tanned synthetic leather is about 0.01 mm to about 5 mm.

7. The method of claim 2 , wherein the fibroblast is derived from a mammal or reptile.

8. The method of claim 7 , wherein the fibroblast is a bovine fibroblast.

9. The method of claim 7 , further comprising forming the tanned synthetic leather into one or more of a watch strap, a belt, a packaging, a shoe, a boot, a footwear, a glove, a clothing, a luggage, a bag, a clutch, a purse, a backpack, a wallet, a saddle, a harness, a whip, or any combination thereof.

10. A composition comprising a cell layer comprising a fibroblast in contact with a scaffold and an extracellular matrix, wherein the extracellular matrix comprises a type I collagen, a type III collagen, or a combination thereof, and wherein the composition is suitable for tanning to form a tanned synthetic leather.

11. The composition of claim 10 , wherein the fibroblast is derived from a mammal or a reptile.

12. The composition of claim 11 , wherein the fibroblast is a bovine fibroblast.

13. The composition of claim 10 , wherein the composition further comprises an extracellular matrix.

14. The composition of claim 10 , wherein the scaffold comprises a natural material, a synthetic material, or a combination thereof.

15. The composition of claim 14 , wherein the scaffold comprises the natural material.

16. The composition of claim 14 , wherein the scaffold comprises the synthetic material.

17. The composition of claim 10 , wherein the tanning comprises a vegetable tanning, a chrome tanning, an aldehyde tanning, a syntan tanning, a bacterial tanning, or any combination thereof.

Assignees

• Faircraft
• King S College London

Inventors

• Helgason Ingvar
• Ilic Dusko

Classifications

• C14C13/00

  Manufacture of special kinds or leather, e.g. vellum (chamois tanning C14C3/14) · CPC title

• C14C3/02

  Chemical tanning · CPC title

• C12N2533/54

  Collagen; Gelatin · CPC title

• C12N2502/094

  keratinocytes · CPC title

• C12N2502/091

  melanocytes · CPC title