Il-15-based fusions to il-7 and il-21
US-2022033455-A1 · Feb 3, 2022 · US
IL-15-based fusions to IL-7 and IL-21
US12410224B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12410224-B2 |
| Application number | US-202318472053-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 21, 2023 |
| Priority date | Aug 28, 2017 |
| Publication date | Sep 9, 2025 |
| Grant date | Sep 9, 2025 |
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Abstract
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The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.
First claim
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What is claimed is: 1. A soluble fusion protein complex comprising: a first fusion protein comprising interleukin-21 (IL-21) (SEQ ID NO: 6) and interleukin-15 receptor alpha sushi-binding domain/Fc (IL-15RαSu/Fc) (SEQ ID NO:8); and a second fusion protein comprising interleukin-7 (IL-7) (SEQ ID NO:10) and an IL-15 variant comprising an N72D mutation (IL-15N72D) (SEQ ID NO:12) or human wild-type IL-15, wherein the first and second fusion proteins are non-covalently linked to form the soluble fusion protein complex. 2. The soluble fusion protein complex of claim 1 , wherein the IL-21 is attached to the N-terminus of the IL-15RαSu/Fc. 3. The soluble fusion protein complex of claim 1 , wherein the IL-21 is attached to the C-terminus of the IL-15RαSu/Fc. 4. The soluble fusion protein complex of claim 2 , wherein the IL-7 is attached to the N-terminus of the IL-15N72D or the human wild-type IL 15. 5. The soluble fusion protein complex of claim 2 , wherein the IL-7 is attached to the C-terminus of the IL-15N72D or the human wild-type IL-15. 6. The soluble fusion protein complex of claim 3 , wherein the IL-7 is attached to the N-terminus of the IL-15N72D or the human wild-type IL-15. 7. The soluble fusion protein complex of claim 3 , wherein the IL-7 is attached to the C-terminus of the IL-15N72D or the human wild-type IL-15. 8. The soluble fusion protein complex of claim 1 , wherein the soluble fusion protein complex is covalently linked to a second soluble fusion protein complex by a disulfide bond linking the Fc domain of the first soluble fusion protein complex to an Fc domain of the second soluble fusion protein complex, wherein the second soluble fusion protein complex is identical to the first soluble fusion protein complex.
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Glucan 1,4-alpha-maltotetraohydrolase (3.2.1.60) · CPC title
Amylo-alpha-1,6-glucosidase (3.2.1.33) · CPC title
Beta-amylase (3.2.1.2) · CPC title
for yeasts · CPC title
with yeasts · CPC title
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- What does patent US12410224B2 cover?
- The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.
- Who is the assignee on this patent?
- Altor Bioscience Llc
- What technology area does this patent fall under?
- Primary CPC classification C07K14/7155. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 09 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).