Skin care composition

Patent metadata

Field	Value
Publication number	US-12409129-B2
Application number	US-201917754433-A
Country	US
Kind code	B2
Filing date	Dec 18, 2019
Priority date	Oct 3, 2019
Publication date	Sep 9, 2025
Grant date	Sep 9, 2025

Abstract

The present invention generally relates to the field of skin care. More particularly, the invention relates to a cosmetic or therapeutic skin care composition comprising live bacteria of at least one Cutibacterium acnes ( C. acnes ) strain in combination with a preservative that specifically supports their viability during storage and/or their ability to replicate after application to the skin. Preferably, the cosmetic or therapeutic skin care composition comprises bacteria of at least one C. acnes strain selected from the group consisting of D1, A5, C1, C3, H1, H2, H3, K1, K2, K4, K6, K8, K9, L1, and F4. The invention also provides a method for treating or preventing acne by applying the skin care composition of the invention to a skin area in need of treatment. The invention also relates to the use of a skin care composition of the invention for treating or preventing acne.

First claim

What is claimed is:

1. A skin care composition, wherein the composition is suitable for topical application to skin and comprises:
(a) lyophilized and/or spray dried live bacteria of at least one cutibacterium acnes ( C. acnes ) single-locus sequence typing (SLST) type C3 strain and/or at least one C. acnes SLST type K8 strain; and
(b) one or more of from 0.05% to 0.5% (w/w) of phenoxyethanol, from 0.05% to 5.0% (w/w) of caprylyl glycol, from 0.05% to 5.0% (w/w) of methylpropanediol as preservative.

2. The skin care composition of claim 1 , wherein the composition at least comprises from 0.05% to 0.5% (w/w) of phenoxyethanol.

3. The skin care composition of claim 1 , wherein the composition at least comprises from 0.05% to 5.0% (w/w) of caprylyl glycol.

4. The skin care composition of claim 1 , wherein the composition at least comprises from 0.05% to 5.0% (w/w) of methylpropanediol.

5. The skin care composition of claim 1 , wherein the composition comprises at least all of phenoxyethanol, caprylyl glycol and methylpropanediol.

6. The skin care composition of claim 5 , wherein the composition comprises from 0.1% to 0.3% (w/w) of phenoxyethanol, from 0.1% to 0.3% (w/w) of caprylyl glycol and from 2.0% to 5.0% (w/w) of methylpropanediol.

7. The skin care composition of claim 1 , wherein the composition further comprises dicaprylyl carbonate and/or ethylhexyl cocoate as emollient.

8. The skin care composition of claim 1 , wherein the composition further comprises Chondrus crispus extract and/or hydroxypropyl starch phosphate as thickener.

9. The skin care composition of claim 1 , wherein the composition further comprises distarch phosphate and/or tapioca starch as filler.

10. The skin care composition of claim 1 , wherein the composition further comprises one or both of tocopherol and tocopheryl acetate as antioxidant.

11. The skin care composition of claim 1 , wherein the composition further comprises PEG-40 hydrogenated castor oil as solubilizer.

12. The skin care composition of claim 1 , wherein the at least one strain of C. acnes further comprises at least one SLST type strain A5 and/or at least one SLST type strain F4.

13. The skin care composition of claim 1 , wherein a concentration of each type of C. acnes strain present in the composition is at least 0.5% (w/v) of the skin care composition.

14. The skin care composition of claim 1 , wherein each type of the C. acnes strain in the composition is present in an amount of from 10 4 to 10 11 CFU/ml.

15. The skin care composition of claim 1 , wherein the composition is present in the form of at least one of a gel, a cream, an ointment or a lotion.

16. The skin care composition of claim 1 , wherein the composition is capable of treating or preventing one or more of acne, oily skin, progressive macular hypomelanosis, dandruff, atopic eczema, atopic dermatitis, rosacea in a subject.

17. The skin care composition of claim 1 , wherein the composition is capable of improving an appearance of skin of a subject and/or of modulating a sebum production of skin cells of a subject and/or of maintaining healthy skin of a subject.

18. The skin care composition of claim 1 , wherein the composition comprises at least one SLST type strain C3.

19. The skin care composition of claim 1 , wherein the composition comprises at least one SLST type strain K8.

20. The skin care composition of claim 1 , wherein the composition comprises at least one SLST type strain D3 and at least one SLST type strain K8.

Assignees

• Beiersdorf Ag
• S Biomedic

Inventors

• Richter Daniel
• Huepeden Jennifer
• Reuter Joern Hendrik
• Foelster Heike
• Felten Bernhard
• Djamil Jane
• Steidle Peter
• Schoendienst Petra
• Hamann Tina
• Gallinat Stefan
• Verheyen Willy
• Pereira De Lima Joäo Pedro Quintão Reis
• Paetzold Bernhard Felix

Classifications

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61K2800/524

  Preservatives · CPC title

• A61K8/345

  containing more than one hydroxy group · CPC title

• A61K8/34

  Alcohols · CPC title

• A61K47/26

  Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin · CPC title