Ophthalmic devices

Patent metadata

Field	Value
Publication number	US-12405488-B2
Application number	US-202217836258-A
Country	US
Kind code	B2
Filing date	Jun 9, 2022
Priority date	Aug 31, 2021
Publication date	Sep 2, 2025
Grant date	Sep 2, 2025

Abstract

A method for preparing an ophthalmic device for slowing, inhibiting or preventing myopia progression involves (a) soaking an ophthalmic device in one or more first solvent solutions to swell the ophthalmic device; (b) soaking the swelled ophthalmic device in one or more second solvents solutions comprising one or more red-light blocking compounds blocking greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nanometers (nm) to about 800 nm to de-swell the swelled ophthalmic device and entrap the one or more red-light blocking compounds in the de-swelled ophthalmic device; and (c) sterilizing the de-swelled ophthalmic device.

First claim

What is claimed is:

1. A method for preparing an ophthalmic device containing one or more red-light blocking compounds, the method comprising:
(a) soaking an ophthalmic device in one or more first solvent solutions to swell the ophthalmic device;
(b) soaking the swelled ophthalmic device in one or more second solvent solutions comprising one or more red-light blocking compounds blocking greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nanometers (nm) to about 800 nm to de-swell the swelled ophthalmic device and entrap the one or more red-light blocking compounds in the de-swelled ophthalmic device; and
(c) sterilizing the de-swelled ophthalmic device;
wherein the one or more first solvent solutions comprise a blend of a low molecular weight alcohol solvent and water, and the ophthalmic device is soaked in the one or more first solvent solutions for a time period ranging from about 5 minutes to about 120 minutes.

2. The method according to claim 1 , wherein the one or more red-light blocking compounds comprise one or more red-light blocking compounds blocking greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nm to about 700 nm.

3. The method according to claim 1 , wherein the one or more red-light blocking compounds comprise one or more red-light blocking compounds blocking greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 650 nm to about 680 nm.

4. The method according to claim 1 , wherein the one or more second solvent solutions comprise water or a blend of a low molecular weight alcohol solvent and water, and the ophthalmic device is soaked in the one or more second solvent solutions for a time period ranging from about 10 minutes to about 18 hours.

5. The method according to claim 1 , wherein the one or more red-light blocking compounds are present in the one or more second solvent solutions in an amount ranging from about 0.05 to about 5 wt. %, based on the total weight of the one or more second solvent solutions.

6. The method according to claim 1 , further comprising soaking the de-swelled ophthalmic device in water to further de-swell the de-swelled ophthalmic device prior to step (c).

7. The method according to claim 1 , wherein step (c) comprises autoclaving the de-swelled ophthalmic device.

8. The method according to claim 1 , wherein the ophthalmic device is one or more of a contact lens, an intraocular lens and a corneal implant.

9. The method according to claim 1 , wherein the one or more red-light blocking compounds are represented by one or more of the following compounds:

wherein X 1 and X 2 are independently CH 2 or C(CH 3 ) 2 ; R 1 and R 2 are independently H or (CH 2 ) 4 SO 3 Na, and R 3 is H or SO 3 Na.

10. A method for preparing an ophthalmic device containing one or more red-light blocking compounds, the method comprising:
(a) soaking an ophthalmic device in one or more first solvent solutions to swell the ophthalmic device;
(b) soaking the swelled ophthalmic device in one or more second solvent solutions comprising one or more red-light blocking compounds blocking greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nanometers (nm) to about 800 nm to de-swell the swelled ophthalmic device and entrap the one or more red-light blocking compounds in the de-swelled ophthalmic device; and
(c) sterilizing the de-swelled ophthalmic device;
wherein step (a) comprises:
(i) soaking the ophthalmic device in the one or more first solvent solutions comprising a blend of a low molecular weight alcohol solvent and water for a time period ranging from about 5 minutes to about 120 minutes; and
(ii) soaking the ophthalmic device of step (i) in one or more additional solvent solutions each comprising one or more of the same or different low molecular weight alcohol solvent, an aliphatic hydrocarbon solvent, a cycloaliphatic hydrocarbon solvent, a ketone solvent, a nitrile solvent, an ether solvent, an amido group-containing solvent and water for a time period ranging from about 5 minutes to about 60 minutes.

11. The method according to claim 10 , wherein the one or more red-light blocking compounds comprise one or more red-light blocking compounds blocking greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nm to about 700 nm.

12. The method according to claim 10 , wherein the one or more red-light blocking compounds comprise one or more red-light blocking compounds blocking greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 650 nm to about 680 nm.

13. The method according to claim 10 , wherein the one or more red-light blocking compounds are represented by one or more of the following compounds:

wherein X 1 and X 2 are independently CH 2 or C(CH 3 ) 2 ; R 1 and R 2 are independently H or (CH 2 ) 4 SO 3 Na, and R 3 is H or SO 3 Na.

14. The method according to claim 10 , wherein the one or more second solvent solutions comprise water or a blend of a low molecular weight alcohol solvent and water, and the ophthalmic device is soaked in the one or more second solvent solutions for a time period ranging from about 10 minutes to about 18 hours.

15. The method according to claim 10 , wherein the one or more red-light blocking compounds are present in the one or more second solvent solutions in an amount ranging from about 0.05 to about 5 wt. %, based on the total weight of the one or more second solvent solutions.

16. The method according to claim 10 , further comprising soaking the de-swelled ophthalmic device in water to further de-swell the de-swelled ophthalmic device prior to step (c).

17. The method according to claim 10 , wherein step (c) comprises autoclaving the de-swelled ophthalmic device.

18. The method according to claim 10 , wherein the ophthalmic device is one or more of a contact lens, an intraocular lens and a corneal implant.

19. A method for preparing an ophthalmic device containing one or more red-light blocking compounds, the method comprising:
(a) soaking an ophthalmic device in one or more first solvent solutions to swell the ophthalmic device;
(b) soaking the swelled ophthalmic device in one or more second solvent solutions comprising one or more red-light blocking compounds blocking greater than about 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nanometers (nm) to about 800 nm to de-swell the swelled ophthalmic device and entrap the one or more red-light blocking compounds in the de-swelled ophthalmic device; and
(c) sterilizing the de-swelled ophthalmic device;
wherein the one or more red-light blocking compounds are represented by one or more of the following compounds:

wherein X 1 and X 2 are independently

Assignees

• Bausch & Lomb Ireland Ltd

Inventors

• Awasthi Alok Kumar
• Hovinga Kristen Rae
• Gabriel Emily Abrams
• Deryke Kevin Jacob
• Russell Jade J
• Ingham Alana

Classifications

• G02C2202/24

  Myopia progression prevention · CPC title

• G02C7/049 Primary

  Contact lenses having special fitting or structural features achieved by special materials or material structures · CPC title

• C07D409/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• C07D403/14

  containing three or more hetero rings · CPC title

• C07D403/10

  linked by a carbon chain containing aromatic rings · CPC title