Method and system for calibrating sensing circuitry of an implanted medical device

Patent metadata

Field	Value
Publication number	US-12402836-B2
Application number	US-202217810923-A
Country	US
Kind code	B2
Filing date	Jul 6, 2022
Priority date	Sep 15, 2021
Publication date	Sep 2, 2025
Grant date	Sep 2, 2025

Abstract

A system is provided that includes electrodes configured to be implanted in a body, and a pulse generator (PG) circuitry to deliver a stimulus to one or more of the electrodes. The system also includes sensing circuitry configured to define a sensing channel between one or more of the electrodes to sense signals indicative of a physiologic activity of interest, and the sensing circuitry further configured to collect a calibration signal over the sensing channel. The sensing circuitry and PG circuitry are housed within an implantable medical device (IMD). The system also includes one or more processors configured to determine a signal characteristic of interest (COI) of the calibration signal. The one or more processors are also configured to compare a signal COI of the stimulus to the signal COI of the calibration signal, and adjust a parameter of the sensing circuitry or PG circuitry based on the comparison.

First claim

What is claimed is:

1. A system, comprising:
electrodes configured to be implanted in a body;
pulse generator (PG) circuitry to deliver a stimulus to one or more of the electrodes, the stimulus having a signal characteristic of interest (COI);
sensing circuitry configured to define a sensing channel between one or more of the electrodes to sense signals indicative of a physiologic activity of interest, the sensing circuitry further configured to collect a calibration signal over the sensing channel;
wherein the sensing circuitry and PG circuitry are housed within an implantable medical device (IMD);
one or more processors; and
a memory coupled to the one or more processors, the memory configured to store program instructions that are executable by the one or more processors to:
determine a signal COI of the calibration signal;
compare the signal COI of the stimulus to the signal COI of the calibration signal; and
adjust a parameter of the sensing circuitry or PG circuitry based on the comparison.

2. The system of claim 1 , wherein the one or more processors are further configured to adjust, as the parameter, at least one of a gain, or a sensitivity correction factor in an analog/digital converter (ADC), of the sensing circuitry.

3. The system of claim 1 , wherein to adjust the parameter of the sensing circuitry or PG circuitry based on the comparison, the one or more processors are further configured to convert, with analog to digital converter (ADC) of the sensing circuitry, an analog output of an amplifier to a digital value; and obtain a sensitivity correction factor to vary the digital value.

4. The system of claim 1 , wherein the sensing circuitry includes a first header node and a second header node coupled to a first analog to digital converter, and a third header node coupled to a second analog to digital converter.

5. The system of claim 1 , wherein the PG circuitry includes a first amplifier electrically coupled to a first control element, and second amplifier electrically coupled to a second control element.

6. The system of claim 5 , further comprising switches configured to connect and disconnect the PG circuit to the header nodes.

7. The system of claim 1 , further comprising:
sensing conductors, within the sensing channel, extending between the sensing circuitry and corresponding header nodes internal to a housing of the IMD; and
PG conductors extending between the PG circuitry and the header nodes internal to the housing of the IMD.

8. The system of claim 1 , wherein the stimulus has an energy level that avoids capture.

9. The system of claim 1 , wherein the sensing channel utilizes a first electrode and a second electrode from the electrodes and the stimulus is delivered to the first electrode and a third electrode from the electrodes.

10. The system of claim 9 , wherein the sensing channel includes an atrial sensing channel between the first electrode and the third electrode and a ventricular sensing channel between the second electrode and the third electrode.

11. The system of claim 10 , wherein the PG circuitry is configured to deliver an atrial calibration stimulus to the first electrode and third electrode and to deliver a ventricular calibration stimulus to the second electrode and third electrode.

12. The system of claim 10 , wherein the one or more processors are further configured to select adjustment of the parameter in one of the atrial sensing channel, or the ventricular sensing channel to update calibration.

13. The system of claim 1 , wherein the stimulus is one of a therapy stimulus or a calibration stimulus.

14. The system of claim 13 , wherein the therapy stimulus provides a greater energy level than an energy level of the calibration stimulus.

15. A method for calibrating sensing circuitry of an implantable medical device, the method comprising:
delivering, with pulse generator (PG) circuity, a stimulus to one or more electrodes configured to be implanted in a body, the stimulus having a signal characteristic of interest (COI);
sensing, with the sensing circuitry, signals indicative of physiologic activity of interest, wherein the sensing circuitry and PG circuitry are housed within the implantable medical device (IMD);
collecting, with the sensing circuitry, a calibration signal over a sensing channel;
determining a signal COI of the calibration signal;
comparing the signal COI of the stimulus to the signal COI of the calibration signal; and
adjusting a parameter of the sensing circuitry or PG circuitry based on the comparison.

16. The method of claim 15 , wherein adjusting the parameter of the sensing circuitry or PG circuitry includes at least one of adjusting a gain of the PG circuitry, or adjusting a sensitivity correction factor in an analog to digital converter (ADC) of the sensing circuitry.

17. The method of claim 15 , wherein adjusting the parameter of the sensing circuitry or PG circuitry comprises:
converting, with an analog to digital converter (ADC) of the sensing circuitry, an analog output of an amplifier to a digital value; and
obtaining a sensitivity correction factor to vary the digital value.

18. The method of claim 15 , further comprising delivering an atrial calibration stimulus to a first electrode and a third electrode of the sensing circuitry to generate an atrial calibration signal, and delivering a ventricular calibration stimulus to a second electrode and the third electrode to generate a ventricular calibration signal.

19. The method of claim 18 , further comprising actuating, with an electrode controller, a first switch to deliver the atrial calibration stimulus to the first electrode and the third electrode, and a second switch to deliver the ventricular calibration signal to the second electrode and the third electrode.

20. The method of claim 15 , further comprising:
selecting adjustment of the parameter in one of an atrial sensing channel, or a ventricular sensing channel; and
calibrating the sensing circuitry based on the adjustment selected.

Assignees

• Pacesetter Inc

Inventors

• Labbe Eric
• Andersen Dean
• Li Shuo

Classifications

• A61N1/37282

  characterised by communication with experts in remote locations using a network · CPC title

• A61N1/36542

  controlled by body motion, e.g. acceleration · CPC title

• A61N1/36521

  the parameter being derived from measurement of an electrical impedance · CPC title

• A61N1/3704

  Circuits specially adapted therefor, e.g. for sensitivity control · CPC title

• A61B5/686 Primary

  Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence) · CPC title