Stent with expandable foam

Patent metadata

Field	Value
Publication number	US-12310835-B2
Application number	US-202418406467-A
Country	US
Kind code	B2
Filing date	Jan 8, 2024
Priority date	Oct 2, 2003
Publication date	May 27, 2025
Grant date	May 27, 2025

Abstract

A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure.

First claim

The invention claimed is:

1. A system comprising:
first and second shape memory polymers (SMPs);
wherein the first SMP: (a) is a cross-linked, biodegradable foam that includes a first channel, (b) is in a first state and is configured to expand to a second state, radially outward from the second SMP, in response to thermal stimulus, (c) has a glass transition temperature (Tg) between 30° C. and 86° C.; and (d) is configured to have hysteresis corresponding to the Tg;
wherein the second SMP: (a) is included in a frame having openings, a first strut that includes the second SMP, and a second strut that includes the second SMP, and (b) is included in the first channel;
wherein the first and second SMPs are coupled to a wire;
wherein the foam adheres to the second SMP via a polyurethane-based adhesive;
wherein the first SMP is configured to extend within the openings when in the second state.

2. The system of claim 1 , wherein the wire is configured to guide the first and second SMPs within a vascular system and to a physiological void.

3. The system of claim 1 , wherein the polyurethane-based adhesive is a thermoset polymer.

4. The system of claim 1 , wherein the foam is configured to have, in the second state, a volumetric void fraction greater than 98% and less than 100%.

5. The system of claim 1 , wherein the foam is configured to have the hysteresis corresponding to the Tg in response to absorption of physiological compounds that act as plasticizers.

6. The system of claim 1 , wherein the frame is a stent.

7. The system of claim 1 , wherein the foam is a thermoset polyurethane polymer.

8. The system of claim 1 , wherein the foam includes a polymer that comprises polymerized monomers, the monomers including at least two of a diisocyanate, triethanolamine (TEA), hydroxypropyl ethylenediamine (HPED), or combinations thereof.

9. The system of claim 8 , wherein the monomers include the diisocyanate and the diisocyanate includes Hexamethylene diisocyanate (HDI).

10. The system of claim 8 , wherein the monomers include the TEA and the HPED.

11. The system of claim 8 , wherein the monomers include the diisocyanate, the TEA, and the HPED.

12. The system of claim 8 , wherein the foam is a thermoset polyurethane polymer.

13. The system of claim 12 , wherein the polyurethane-based adhesive is a thermoset polymer.

14. The system of claim 13 , wherein the foam is configured to have the hysteresis corresponding to the Tg in response to absorption of physiological compounds that act as plasticizers.

15. The system of claim 14 , wherein the foam is configured to have, in the second state, a volumetric void fraction greater than 98% and less than 100%.

16. The system of claim 1 , wherein the first SMP has a volume expansion between 100% and 10,000%.

17. A system comprising:
a first shape memory polymer (SMP) foam and a second SMP;
a second foam coupled to the second SMP;
wherein the first SMP foam: (a) is a cross-linked, biodegradable foam that includes a first channel, (b) is in a first state and is configured to expand to a second state, radially outward from the second SMP, in response to thermal stimulus, (c) has a glass transition temperature (Tg) between 30° C. and 86° C.; and (d) is configured to have hysteresis corresponding to the Tg;
wherein the second SMP: (a) is included in a frame having a first strut that includes the second SMP and a second strut that includes the second SMP, and (b) is included in the first channel;
wherein the first SMP foam and the second SMP are coupled to a wire;
wherein the first SMP foam adheres to the second SMP via a polyurethane-based adhesive.

18. The system of claim 17 , wherein the second foam is included within the frame.

19. The system of claim 18 , wherein the second foam is removably coupled within the frame.

20. The system of claim 17 , wherein the first SMP has a volume expansion between 100% and 10,000%.

Assignees

• L Livermore Nat Security Llc
• Univ California

Inventors

• Wilson Thomas S
• Maitland Duncan J
• Small Iv Ward
• Buckley Patrick R
• Benett William J
• Hartman Jonathan
• Saloner David

Classifications

• A61F2/95

  Instruments specially adapted for placement or removal of stents or stent-grafts · CPC title

• A61B2017/1205

  Introduction devices · CPC title

• A61B2017/12077

  Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory · CPC title

• A61B2017/12072

  the heat created by laser light · CPC title

• A61B2017/12054

  Details concerning the detachment of the occluding device from the introduction device · CPC title