Stent with expandable foam

Patent metadata

Field	Value
Publication number	US-11864989-B2
Application number	US-202017070053-A
Country	US
Kind code	B2
Filing date	Oct 14, 2020
Priority date	Oct 2, 2003
Publication date	Jan 9, 2024
Grant date	Jan 9, 2024

Abstract

A system comprising first, second, and third shape memory polymers (SMPs); wherein (a) the first SMP is a biodegradable open cell foam that includes a first channel; (b) the second SMP includes a second channel and is included in the first channel; (c) the foam is in a first state and is configured to expand to a second state, radially outward from the second foam, in response to thermal stimulus; (d) the third SMP is between the first and second SMPs and includes a stent having a first strut that includes the third SMP and a second strut that includes the third SMP; and (e) each of the first, second, and third SMPs is coupled to a wire.

First claim

The invention claimed is:

1. A system comprising:
first, second, and third shape memory polymers (SMPs);
wherein the first SMP is a biodegradable open cell foam that includes a first channel;
wherein the second SMP includes a second channel and is included in the first channel;
wherein the foam is in a first state and is configured to expand to a second state, radially outward from the second SMP, in response to thermal stimulus;
wherein the third SMP is between the first and second SMPs and includes a stent having a first strut that includes the third SMP and a second strut that includes the third SMP;
wherein each of the first, second, and third SMPs is coupled to a wire.

2. The system of claim 1 , wherein the foam has a glass transition temperature (Tg) between 30° C. and 86° C.

3. The system of claim 2 , wherein the first SMP is cross-linked.

4. The system of claim 3 , wherein the foam is a first thermoset foam and the second SMP is a second thermoset SMP foam.

5. The system of claim 4 , wherein the first SMP includes a reaction product of at least two of Hexamethylene diisocyanate (HDI), triethanolamine (TEA), hydroxypropyl ethylenediamine (HPED), or combinations thereof.

6. A system comprising:
first and second shape memory polymers (SMPs);
wherein the first SMP: (a) is a cross-linked, biodegradable, open cell foam that includes a first channel, (b) is in a first state and is configured to expand to a second state, radially outward from the second SMP, in response to thermal stimulus, (c) has a glass transition temperature (Tg) between 30° C. and 86° C.; and (d) is configured to have hysteresis corresponding to the Tg;
wherein the second SMP: (a) is a frame having a first strut that includes the second SMP and a second strut that includes the second SMP, and (b) is included in the first channel;
wherein the first and second SMPs are coupled to a wire;
wherein the foam adheres to the second SMP via a polyurethane-based adhesive.

7. The system of claim 6 , wherein the foam includes a reaction product of at least two of a diisocyanate, triethanolamine (TEA), hydroxypropyl ethylenediamine (HPED), or combinations thereof.

8. The system of claim 7 , wherein the foam includes a reaction product of the diisocyanate and the diisocyanate includes Hexamethylene diisocyanate (HDI).

9. The system of claim 7 , wherein the foam includes a reaction product of the TEA and the HPED.

10. The system of claim 7 , wherein the foam includes a reaction product of the diisocyanate, the TEA, and the HPED.

11. The system of claim 6 , wherein the wire is configured to guide the first and second SMPs within a vascular system and to a physiological void.

12. The system of claim 7 , wherein the polyurethane-based adhesive is a thermoset polymer.

13. The system of claim 6 , wherein the foam is configured to have, in the second state, a volumetric void fraction greater than 98% and less than 100%.

14. The system of claim 6 , wherein the foam is configured to have the hysteresis corresponding to the Tg in response to absorption of physiological compounds that act as plasticizers.

15. The system of claim 6 , wherein the second SMP is a stent.

16. The system of claim 6 , wherein the foam is a thermoset polyurethane polymer.

17. A system comprising:
a first SMP that is an open cell foam that includes a first channel and has a glass transition temperature (Tg) between 30° C. and 86° C.; and
a second SMP included in the first channel and including a frame which has a first strut that includes the second SMP and a second strut that includes the second SMP;
wherein the first and second SMPs are coupled to a wire;
wherein the first SMP: (a) adheres to the second SMP via a polyurethane-based adhesive; and (b) is configured to have hysteresis corresponding to the Tg.

18. The system of claim 17 , wherein:
the foam is in a first state and is configured to expand to a second state, radially outward from the second SMP, in response to thermal stimulus;
the first SMP is crimped and the second SMP is crimped;
the first SMP is a thermoset polyurethane polymer.

Assignees

• L Livermore Nat Security Llc
• Univ California

Inventors

• Wilson Thomas S
• Maitland Duncan J
• Small Iv Ward
• Buckley Patrick R
• Benett William J
• Hartman Jonathan
• Saloner David

Classifications

• A61B2017/1205

  Introduction devices · CPC title

• A61F2/06 Primary

  Blood vessels · CPC title

• A61B17/1214

  Coils or wires · CPC title

• A61B17/12022 Primary

  Occluding by internal devices, e.g. balloons or releasable wires (plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20) · CPC title

• A61B17/12113

  within an aneurysm · CPC title