Method for preparing sodium taurate as taurine intermediate, and method for preparing taurine

Patent metadata

Field	Value
Publication number	US-12275692-B2
Application number	US-202017424454-A
Country	US
Kind code	B2
Filing date	May 27, 2020
Priority date	May 30, 2019
Publication date	Apr 15, 2025
Grant date	Apr 15, 2025

Abstract

A method for preparing sodium taurine as a taurine intermediate is provided in the present disclosure. The method comprises the following steps: providing sodium hydroxyethyl sulfonate and an ammonia source; and placing the sodium hydroxyethyl sulfonate and the ammonia source in an aminolysis reactor for an aminolysis reaction to obtain a mixture containing sodium taurine as a taurine intermediate, wherein the molar ratio of ammonia in the ammonia source to the sodium hydroxyethyl sulfonate is greater than or equal to 25:1. A method for preparing taurine is further provided.

First claim

We claim:

1. A method for preparing sodium taurine as a taurine intermediate, comprising:
providing sodium hydroxyethyl sulfonate and an ammonia source; and
feeding the sodium hydroxyethyl sulfonate and the ammonia source into an aminolysis reactor for an aminolysis reaction to obtain a mixture containing sodium taurine as a taurine intermediate, wherein a molar ratio of ammonia in the ammonia source to the sodium hydroxyethyl sulfonate is greater than or equal to 25:1, and
after the aminolysis reaction, separating unreacted ammonia from the mixture with an ammonia separating device, so as to obtain an ammonia-containing gas and the taurine intermediate, respectively, wherein the ammonia separating device is connected to the aminolysis reactor; and
compressing the ammonia-containing gas with a compression unit to obtain a supercritical fluid containing ammonia, and circulating the supercritical fluid to the aminolysis reactor, wherein the compression unit is connected to the ammonia separating device and the aminolysis reactor, respectively.

2. The method of claim 1 , wherein the ammonia separating device comprises one ammonia separator.

3. The method of claim 1 , wherein the ammonia separating device comprises two ammonia separators, which are defined as a first ammonia separator and a second ammonia separator, respectively;
wherein the first ammonia separator is connected to the aminolysis reactor, the first ammonia separator is configured for separating the unreacted ammonia from the mixture after the aminolysis reaction to obtain a first ammonia-containing gas and a first residuum mixture; and
wherein the second ammonia separator is connected to the first ammonia separator, the second ammonia separator is configured for further separating ammonia gas from the first residuum mixture to obtain a second ammonia-containing gas and a second residuum, and circulating the second ammonia-containing gas to the first ammonia separator.

4. The method of claim 3 , wherein the compression unit comprises a first compression unit and a second compression unit;
wherein the first compression unit is connected to the first ammonia separator and the aminolysis reactor, respectively, and the first compression unit is configured for compressing the ammonia-containing gas in the first ammonia separator to obtain the supercritical fluid, and circulating the supercritical fluid to the aminolysis reactor; and
wherein the second compression unit is connected to the first ammonia separator and the second ammonia separator, respectively, and the second compression unit is configured for circulating the second ammonia-containing gas to the first ammonia separator.

5. The method of claim 1 , wherein the ammonia separating device comprises a plurality of sequentially arranged ammonia separators, a number of the plurality of ammonia separators is n, and n is an integer which is greater than 2 and less than 20;
wherein a first ammonia separator of the plurality of ammonia separators is connected to the aminolysis reactor, the first ammonia separator is configured for separating the unreacted ammonia from the mixture after the aminolysis reaction to obtain a first ammonia-containing gas and a first residuum mixture;
wherein a second ammonia separator of the plurality of ammonia separators is connected to the second ammonia separator, the second ammonia separator is configured for further separating ammonia gas from the first residuum mixture to obtain a second ammonia-containing gas and a second residuum, and circulating the second ammonia-containing gas to the first ammonia separator; and
wherein an i th ammonia separator of the plurality of ammonia separators is connected to an i-l th ammonia separator, wherein i is an integer which is greater than 2 and less than or equal to an integer ‘n’, the i th ammonia separator is configured for further separating ammonia gas from an i-l th residuum mixture to obtain an i th ammonia-containing gas and an i th residuum, and circulating the i th ammonia-containing gas to the i-l th ammonia separator.

6. The method of claim 5 , wherein the aminolysis reaction is conducted through an aminolysis reaction system comprising a plurality of compression units, a number of the plurality of compression units is n;
wherein a first compression unit of the plurality of compression units is connected to the first ammonia separator and the aminolysis reactor, respectively, and the first compression unit is configured for compressing the ammonia-containing gas in the first ammonia separator to obtain the supercritical fluid, and circulating the supercritical fluid to the aminolysis reactor;
wherein a second compression unit of the plurality of compression units is connected to the first ammonia separator and the second ammonia separator, respectively, and the second compression unit is configured for circulating the second ammonia-containing gas to the first ammonia separator; and
wherein an i th compression unit of the plurality of compression units is connected to the i-l th ammonia separator and the i th ammonia separator, respectively, and the i th compression unit is configured for circulating the i th ammonia-containing gas to the i-l th ammonia separator.

7. The method of claim 5 , wherein n is equal to three or four.

8. The method of claim 1 , further comprising a step of supplementing the ammonia source into the ammonia separating device.

Assignees

• Zhejiang Nhu Co Ltd
• Univ Zhejiang
• Shangyu Nhu Bio Chem Co Ltd
• Zhejiang Nhu Pharmaceutical Co Ltd

Inventors

• Chen Zhirong
• Yao Xianghua
• Peng Junhua
• Pan Yingxia
• He Xiaoxiang
• Xu Songhua
• Wu Xiaodong
• Fang Xiang

Classifications

• B01J19/2475

  Membrane reactors · CPC title

• B01J19/2465

  externally, i.e. the mixture leaving the vessel and subsequently re-entering it · CPC title

• B01J3/008

  Processes carried out under supercritical conditions · CPC title

• B01D61/445

  with bipolar membranes; Water splitting · CPC title

• B01D3/06 Primary

  Flash distillation · CPC title