NO donor compound, preparation method thereof, pharmaceutical composition comprising same, and use thereof

Patent metadata

Field	Value
Publication number	US-12275686-B2
Application number	US-202418812980-A
Country	US
Kind code	B2
Filing date	Aug 22, 2024
Priority date	Feb 22, 2022
Publication date	Apr 15, 2025
Grant date	Apr 15, 2025

Abstract

Disclosed is NO donor compound and preparation method, pharmaceutical composition, and use. The compound has a structure represented by formula The NO donor compound and the pharmaceutical composition thereof, as hypoxia-activated NO donors, may be prepared as drugs for treating myocardial hypoxic damage disease. The prepared drugs can exert efficacy at both the cellular level and the animal level, and the synthesis method of the compound is simple and easy to operate.

First claim

What is claimed is:

1. A NO donor compound, wherein a structure of the NO donor compound is represented by a formula I:

wherein:
when R1 is nitro group, R2 is selected from the group consisting of hydrogen, halogen, and C 1 -C 4 alkyl, R3 is selected from the group consisting of hydrogen, halogen, and C 1 -C 4 alkyl; or
when R2 is selected from the group consisting of nitro group, R1 is hydrogen, halogen, and C 1 -C 4 alkyl, and R3 is selected from the group consisting of hydrogen, halogen, and C 1 -C 4 alkyl.

2. The NO donor compound of claim 1 , wherein in the formula I, R1 is nitro group, R2 is selected from the group consisting of hydrogen, halogen, and methyl, and R3 is hydrogen.

3. The NO donor compound of claim 1 , wherein the NO donor compound is selected from the group consisting of following compounds I1-I4:

4. A method for preparing the NO donor compound of claim 1 , comprising: obtaining the NO donor compound of formula I by acylation reaction between compound 1 and compound 2 as follows:

5. A pharmaceutical composition, comprising the NO donor compound of claim 1 and a pharmaceutically acceptable carrier.

Assignees

• Univ Southeast

Inventors

• Gou Shaohua
• Yang Wanxiang

Classifications

• C07C243/06 Primary

  N-nitroso-amines · CPC title

• A61K31/196

  the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil · CPC title

• A61P9/10 Primary

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61K31/655

  Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds · CPC title

• C07C241/00

  Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes · CPC title